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"What we've done is improve a therapeutic approach to delivering enzyme-producing genes that can convert certain drugs into toxic agents and target tumours." Pixabay

Massachusetts Institute of Technology (MIT) researchers have developed a fast-acting skin patch that efficiently delivers medication to attack cells in melanoma – a deadly form of skin cancer.

Topical ointments can impart medications to the skin, but they can only penetrate a small distance through it.


While syringes are an effective drug delivery mode, they can be painful. Syringes can also be inconvenient for patients, leading to non-compliance.

“Our patch has a unique chemical coating and mode of action that allows it to be applied and removed from the skin in just a minute while still delivering a therapeutic dose of drugs,” says Yanpu He, a graduate student who helped develop the device.


Massachusetts Institute of Technology (MIT) researchers have developed a fast-acting skin patch that efficiently delivers medication to attack cells in melanoma – a deadly form of skin cancer. Pixabay

The researchers believe that the skin patch, tested in mice and human skin samples, is an advance toward developing a vaccine to treat melanoma, a deadly form of skin cancer.

“Our patches elicit a robust antibody response in living mice and show promise in eliciting a strong immune response in human skin,” He said.

Using chicken ovalbumin as a model antigen, the team vaccinated mice with their patches, and compared the results with intramuscular and subcutaneous injections.

The microneedle treatment produced nine times the antibody level compared to intramuscular injections (used for flu shots) and 160 times the antibody level compared to subcutaneous injections (used for measles vaccines). They also saw efficient immune activation in surgical samples of human skin.

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“Our patch technology could be used to deliver vaccines to combat different infectious diseases,” said Paula T. Hammond from MIT.

“But we are excited by the possibility that the patch is another tool in the oncologists’ arsenal against cancer, specifically melanoma,” Hammond said.

The findings are scheduled to be presented at the American Chemical Society (ACS) Fall 2019 National Meeting and Exposition being held in San Diego, California, from August 25-29. (IANS)


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The New Indian Express/wikipedia

Named SEE-1, the module is intended to host films, etc in the low orbit, micro-gravity environment.

S.E.E. has unveiled plans to build a space station module that contains a sports and entertainment arena as well as a content studio by December 2024, reports variety.com.

Named SEE-1, the module is intended to host films, television, music and sports events as well as artists, producers and creatives who want to make content in the low orbit, micro-gravity environment. The facilities will enable development, production, recording, broadcasting and livestreaming of content.

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S.E.E. intend to produce its own content and events in the module as well as making it available to third-parties. Axiom Space, who in January 2022 won NASA's approval to build a commercial component of the International Space Station (ISS), will undertake the construction of SEE-1. The module will dock on Axiom's commercial arm, named Axiom Station, which will also host other commercial ventures, including space tourism.

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IANS

As the economy continues to recover from the prolonged pandemic.

By Rohit Vaid
The Centre might bestow infrastructure as well as industry status to new sectors to boost several pandemic hit industries in the upcoming Union Budget. Industry insiders said that several sectors and sub-industries such as hospitality, automobile retail, specific diganotics facilities and companies engaged in installation of EV charging stations amongst others might get the status.
The infra tag will enable these sectors to avail tax breaks, incentives and credit on lower interest rates. "Sectors which are in greenfield or which would need capex augmentation to help them overcome the pandemic can be looked from the lens of an infrastructure sector," said Jagannarayan Padmanabhan, Director and Practice Leader, Transport & Logistics, Crisil Infrastructure Advisory. "Also many of the already identified sectors need a sustained policy push which will help them get visibility both in terms of quantum and the time period of applicability."

Till now, activities associated with laying of power and telecom transmission and distribution lines, roads, highways, railways and construction of facilities such as hospitals, affordable housing, power generation units, water treatment plants, SEZs and certain type of hotels amongst others were given such status.

Besides, these sectors are a part of harmonised master list for infrastructure sub-sectors. However, in April 2021, exhibition-cum-convention centre was included in the list. "Given the focus around electric vehicle, and need for significant investment in charging stations, if the government adds the sector in infrastructure list, the benefits arising out of it will be significant," said Vishal Kotecha, Director, India Ratings and Research. "Infra tag on sectors increases ability to raise funds, access to dedicated funds and lenders, foreign capital, lower interest rates among others."

Electric car Given the focus on electric vehicles, the advantages of including the industry in the infrastructure list will be enormous. Free SVG

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Wikipedia

A team is working to produce safest medicine for covid treatment.

A team led by chief scientist Ravi Shankar, is working on two combinations to provide the safest medication to coronavirus patients. "Experts say that a combination of antivirals with different mechanisms can be more effective to counter the viral pandemic. We are working on two combinations - Umifenovir with Molnupiravir (an antiviral) and Umifenovir with Niclosamide (anti-parasitic)," he said.

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Molnupiravur drug has received only Emergency Use Authorisation in India and abroad. Though its usage showed reduced hospitalisation during clinical trials, its biggest drawback are the side-effects, he added.

"Now, we are trying to keep a low dosage of Molnupiravir in its combination with Umifenovir which may weed out the side-effects such as the risk of cartilage and muscle damage. If successful, it will make Umifenovir more effective in Covid-19 treatment," said the chief scientist. The other combination is Umifenovir with Niclosamide.

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