Thursday November 22, 2018

Father’s stress linked to kids’ brain development

The researchers noted that by learning more about links between a father's exposure to stress and the risks of disease for his kid, we can better understand, detect, and prevent these disorders

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But, administration of a drug that chemically blocks NkB-specific receptors enabled the stressed mice to behave normally, eliminating the negative effects of social isolation.
Representational image. Wikimedia Commons
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  • According to the researchers, the stress changes the father’s sperm which can then alter the brain development of the child
  • Research found that the father’s sperm showed changes in a genetic material known as microRNA

Fathers, take note! Taking too much stress may affect the brain development of your kids, a new study has claimed.

According to the researchers, the stress changes the father’s sperm which can then alter the brain development of the child.

This new research provides a much better understanding of the key role that fathers play in the brain development of their kids, the researchers said.

Previously, the researchers including Tracy Bale at the University of Maryland School found that adult male mice, experiencing chronic periods of mild stress, have offspring with a reduced response to stress; changes in stress reactivity have been linked to some neuropsychiatric disorders, including depression and PTSD.

Also Read: Surgical Infections More Common in Low-Income Countries, Study Finds

They isolated the mechanism of the reduced response; they found that the father’s sperm showed changes in a genetic material known as microRNA.

MicroRNA are important because they play a key role in which genes become functional proteins.

According to the researchers, the stress changes the father's sperm which can then alter the brain development of the child.
According to the researchers, the stress changes the father’s sperm which can then alter the brain development of the child. Wikimedia Commons

Now, the researchers have unravelled new details about these microRNA changes.

In the male reproductive tract, the caput epididymis, the structure where sperm matures, releases tiny vesicles packed with microRNA that can fuse with sperm to change its cargo delivered to the egg, they said.

The caput epididymis responded to the father’s stress by altering the content of these vesicles, the researchers added.

Also Read: Girls may inherit ovarian cancer gene from fathers

The result of the study, presented at AAAS 2018 annual meeting in Austin, suggests that even mild environmental challenges can have a significant impact on the development and potentially the health of future offspring.

The researchers also noted that by learning more about links between a father’s exposure to stress and the risks of disease for his kid, we can better understand, detect, and prevent these disorders. (IANS)

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Poor Aerobic Fitness Increases Risk of Diabetes in Kids

Their aerobic fitness was determined by measuring peak oxygen uptake during a maximal exercise test

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Diabetes
Poor aerobic fitness can up diabetes, heart disease risk in kids. Pixabay

Lack of exercise, particularly poor aerobic fitness, in children increases their risk for developing Type-2 diabetes and cardiovascular disease, says a new study.

Children with poor aerobic fitness in proportion to their total body mass were found to have a significantly higher risk of Type-2 diabetes and cardiovascular disease than their peers having better aerobic fitness.

“Measures of aerobic fitness that are based on total body mass are better at predicting the risk of Type-2 diabetes and cardiovascular disease than measures that are based on skeletal muscle mass,” said Andrew Agbaje, lead researcher from the University of Eastern Finland.

“However, they exaggerate the role of aerobic fitness in children’s health,” he added.

For the study, researchers determined threshold values of aerobic fitness for 352 children, aged between 9 and 11 who are at an increased risk of Type-2 diabetes and cardiovascular disease.

Diabetes
Representational image. Pixabay

Their aerobic fitness was determined by measuring peak oxygen uptake during a maximal exercise test.

The team also calculated variables indicative of the risk of Type-2 diabetes and cardiovascular disease, such as waist circumference, blood levels of insulin, glucose, HDL cholesterol, and triglycerides as well as blood pressure.

Also Read- Your Genes May Not Help You Live Long

The study, published in the journal Scandinavian Journal of Medicine & Science in Sports, found that the traditional way of expressing aerobic fitness in proportion to total body mass overestimates the role of aerobic fitness in identifying children at an increased risk of these diseases.

“We should be cautious when interpreting aerobic fitness measures that are proportioned to total body mass in order to correctly identify children who truly need health and lifestyle intervention,” Agbaje noted. (IANS)