Wednesday November 20, 2019

Fatty Tissues Accumulate Inside Lungs of Obese People: Study

The researchers examined post-mortem samples of the lungs that had been donated for the research and stored in the Airway Tissue Biobank

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Obese
Excess fat accumulates in the airway walls of Obese people where it takes up space and seems to increase inflammation within the lungs. Pixabay

Researchers have found that fatty tissues accumulate in the airway walls, particularly in people who are overweight or obese.

The study, published in the European Respiratory Journal, suggested that the fatty tissue alters the structure of people’s airways and this could be one reason behind the increased risk of asthma.

“Our research team studies the structure of the airways within our lungs and how these are altered in people with respiratory disease,” said the study’s author John Elliot from Sir Charles Gairdner Hospital in Australia.

“Looking at the samples of lungs, we spotted fatty tissue that had built up in the airway walls. We wanted to see if this accumulation was correlated with body weight,” Elliot said.

The researchers examined post-mortem samples of the lungs that had been donated for the research and stored in the Airway Tissue Biobank.

They studied samples from 52 people, including 15 who had no asthma, 21 who had the disease but died of other causes and 16 who died of asthma.

Using dyes to help visualise the structures of 1373 airways under a microscope, they identified and quantified any fatty tissue present.

Obese
Fatty tissue alters the structure of Obese people’s airways and this could be one reason behind the increased risk of asthma. Pixabay

They compared this data with each person’s body mass index (BMI).

The study showed that fatty tissue accumulates in the walls of the airways. The analysis revealed that the amount of fat present increases in line with increasing BMI.

“We’ve found that excess fat accumulates in the airway walls where it takes up space and seems to increase inflammation within the lungs,” said the study’s co-author Peter Noble.

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“We think this is causing a thickening of the airways that limits the flow of air in and out of the lungs, and that could at least partly explain an increase in asthma symptoms,” Noble said. (IANS)

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Soups Can Help You Fight Malaria: Study

Consuming home-made soups can save you from malaria, suggests a new study

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Soups fight malaria
Consuming soups can save you from malaria. Pixabay

“Malaria kills more than 400,000 people per year and infects more than 200 million, yet resistance to our frontline drugs continues to emerge,” said study lead researcher Jake Baum, Professor at Imperial College London, in UK.

“We may have to look beyond the chemistry shelf for new drugs, and natural remedies shouldn’t be off our watch list,” Baum added.

For the study, published in the journal Archives of Disease in Childhood, researchers from Imperial College London with school children test their family soup broths for activity against the malaria parasite.

Several of the soup broths, collected from traditional family recipes that originated around the world, showed activity against the malaria parasite Plasmodium falciparum, either by curbing its growth or preventing it from maturing.

The soup recipes had been passed down through the generations for the treatment of fever.

Five of the broths were able to curb growth of the parasite in its disease-causing stage by more than 50 percent.

In two of these, the inhibitory activity was comparable with that of a leading anti-malarial drug, dihydroartemisinin.

Four other broths were more than 50 percent effective at blocking the ability of the parasites to mature to a form that infects mosquitoes, potentially blocking the process of transmission.

Malaria
Prevent malaria with healthy soups. Pixabay

Dihydroarteminisin contains artemisinin, which was isolated from a traditional Chinese herbal medicine.

According to the researchers, the study was carried out by students at Eden Primary School in North London.

The pupils brought in samples of homemade clear soup broths from family recipes from across Europe, North Africa, and the Middle East.

Filtered extracts of the broths were then tested against two stages of the parasite: when it can infect mosquitoes, and when it can cause the disease in humans.

The recipes for each of the broths varied.

They were vegetarian, chicken, or beef based, with no particular ingredient common to those with the strongest anti-malarial activity.

The active ingredients in the broths studied are yet to be identified and tested, the study said.

To move forwards, the active ingredients would need to be isolated, before tests of toxicology and effectiveness, first in human cells and later preclinical trials.

Also Read- Here’s Why Too Much Ultra-Processed Food Can Deteriorate your Heart Health

The researchers behind the study hope that they may discover new anti-malarial compounds in a similar way from the work looking at soup.

“It’s really interesting to find potential routes for future drug development in something like your grandmother’s soup,” Baum added. (IANS)