Friday January 24, 2020

FDA Approves Drug to Stop Some Malaria Relapses

Worldwide, malaria infects more than 200 million people a year and kills about half a million, most of them children in Africa

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FDA
FILE - The GlaxoSmithKline offices in London. On Friday, the U.S. Food and Drug Administration approved GlaxoSmithKline’s Krintafel, a simpler, one-dose treatment, to prevent relapses of a type of malaria. (VOA)

U.S. regulators Friday approved a simpler, one-dose treatment to prevent relapses of malaria.

Standard treatment now takes two weeks and studies show many patients don’t finish taking every dose.

Malaria is caused by parasites that are spread to people through mosquito bites. Anti-malarial drugs can cure the initial infection, but parasites can get into the liver, hide in a dormant form and cause recurrences months or years later. A second drug is used to stop relapses.

The new drug, GlaxoSmithKline’s Krintafel, only targets the kind of malaria that mainly occurs in South America and Southeast Asia. Most malaria cases and deaths are in Africa, and they involve another species.

In testing, one dose of Krintafel worked about the same as two weeks of the standard treatment, preventing relapses in about three-quarters of patients in six months, the company said.

Malaria is caused by parasites that are spread to people through mosquito bites.
Malaria is caused by parasites that are spread to people through mosquito bites. (VOA)

The Food and Drug Administration approved the drug for patients 16 and older, according to GlaxoSmithKline. The company said it’s the first new treatment in six decades for preventing relapses.

GlaxoSmithKline plans to apply soon for approval in Brazil, then other countries where the malaria type is common. It says it will sell the pills at low cost in poor countries.

Millions infected worldwide

Worldwide, malaria infects more than 200 million people a year and kills about half a million, most of them children in Africa. It causes fever, headache, chills and other flulike symptoms. The malaria type Krintafel targets causes about 8.5 million infections annually.

Also Read: Trial Wipes out More Than 80 per cent of Disease-Spreading Mosquitoes

The British drugmaker, working with the World Health Organization, is also developing what could be the world’s first malaria vaccine, but early testing indicates it’s not very effective. Prevention now focuses on using insecticides and bed nets. (VOA)

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Soups Can Help You Fight Malaria: Study

Consuming home-made soups can save you from malaria, suggests a new study

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Soups fight malaria
Consuming soups can save you from malaria. Pixabay

“Malaria kills more than 400,000 people per year and infects more than 200 million, yet resistance to our frontline drugs continues to emerge,” said study lead researcher Jake Baum, Professor at Imperial College London, in UK.

“We may have to look beyond the chemistry shelf for new drugs, and natural remedies shouldn’t be off our watch list,” Baum added.

For the study, published in the journal Archives of Disease in Childhood, researchers from Imperial College London with school children test their family soup broths for activity against the malaria parasite.

Several of the soup broths, collected from traditional family recipes that originated around the world, showed activity against the malaria parasite Plasmodium falciparum, either by curbing its growth or preventing it from maturing.

The soup recipes had been passed down through the generations for the treatment of fever.

Five of the broths were able to curb growth of the parasite in its disease-causing stage by more than 50 percent.

In two of these, the inhibitory activity was comparable with that of a leading anti-malarial drug, dihydroartemisinin.

Four other broths were more than 50 percent effective at blocking the ability of the parasites to mature to a form that infects mosquitoes, potentially blocking the process of transmission.

Malaria
Prevent malaria with healthy soups. Pixabay

Dihydroarteminisin contains artemisinin, which was isolated from a traditional Chinese herbal medicine.

According to the researchers, the study was carried out by students at Eden Primary School in North London.

The pupils brought in samples of homemade clear soup broths from family recipes from across Europe, North Africa, and the Middle East.

Filtered extracts of the broths were then tested against two stages of the parasite: when it can infect mosquitoes, and when it can cause the disease in humans.

The recipes for each of the broths varied.

They were vegetarian, chicken, or beef based, with no particular ingredient common to those with the strongest anti-malarial activity.

The active ingredients in the broths studied are yet to be identified and tested, the study said.

To move forwards, the active ingredients would need to be isolated, before tests of toxicology and effectiveness, first in human cells and later preclinical trials.

Also Read- Here’s Why Too Much Ultra-Processed Food Can Deteriorate your Heart Health

The researchers behind the study hope that they may discover new anti-malarial compounds in a similar way from the work looking at soup.

“It’s really interesting to find potential routes for future drug development in something like your grandmother’s soup,” Baum added. (IANS)