Sunday November 18, 2018

Foetal Immune Rejection Could be the Reason of Preterm Labor

For the new study, published in the journal Science Translational Medicine, the team tested umbilical cord blood, which contains foetal cells, along with blood taken from nearly 200 women who had healthy pregnancies and those who went into early labour.

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However, when it comes to vaginal delivery, the first thought that crosses most womens' minds is of the labour pain which develops a fear of the VBAC, Pixabay
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Foetal immune rejection may be one of the causes for preterm labour — a common pregnancy complication leading to birth occurring before the 37th week of pregnancy, researchers say.

The findings showed that it may sometimes happen when the foetal immune system “wakes up” too early and begins to reject the mother, causing the uterus to start contracting.

The researchers think the foetal immune system becomes triggered in a case of mistaken identity.

The findings showed that it may sometimes happen when the foetal immune system "wakes up" too early and begins to reject the mother, causing the uterus to start contracting.
Representational Image, pexels

An initial infection in the mother can result in inflammation and arouse the foetal immune system. The foetal immune cells confuse the mother’s cells for an invader and mount an attack, in the form of inflammatory chemicals.

These chemicals then trigger contractions, leading to preterm labour, the leading cause of infant mortality, the researchers explained.

“The dogma has always been that the foetus has a very immature immune system, and as a result, people haven’t really considered its possible role in pregnancy complications,” said Tippi MacKenzie, Associate Professor at the University of California-San Francisco.

“We showed that in patients who have preterm labour as a result of some kind of infection or inflammation — the most common cause of preterm labour — the foetal immune system awakens prematurely and may trigger labour,” MacKenzie added.

For the new study, published in the journal Science Translational Medicine, the team tested umbilical cord blood, which contains foetal cells, along with blood taken from nearly 200 women who had healthy pregnancies and those who went into early labour.

Also Read: Using aspirin may reduce obesity’s effect on cancer, finds study 

While the scientists saw no signs of an immune response in the mother’s blood, they instead, detected activation in two types of immune cells — T-cells and dendritic cells — in the cord blood of preterm infants.

The researchers also found greater numbers of the mother’s cells circulating in the cord blood of preterm infants. (IANS)

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Managing Weight During Pregnancy May Affect Child’s Bone Health

The team analysed prospective data from 2,167 mother-child pairs

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Weight management in pregnancy may affect child's bone health. Pixabay

There is no benefit for children’s bone mass if women gain weight during pregnancy, says a new study.

And this applies to both normal and overweight women prior to pregnancy, says Teresa Monjardino, lead author from the Universidade do Porto in Portugal.

Weight management strategies during pregnancy reduce child cardiometabolic risk such as diabetes and heart disease.

However, because maternal weight has an overall positive correlation with a child’s bone mass, pregnancy weight management could adversely affect child bone health, said the researchers.

The study, published in the Journal of Bone and Mineral Research, showed that in under and normal weight mothers, weight gain during pregnancy was associated with slightly increased bone mass at 7 years of age in children.

Pregnancy, air pollution
Weight management strategies during pregnancy reduce child cardiometabolic risk such as diabetes and heart disease. Pixabay

On the other hand, in the case of overweight or obese mothers, no beneficial effect of weight gain on bone mass was observed.

“Until recently, it was a widely held scientific belief that any weight gain from the mother during pregnancy would have a beneficial effect on children’s bone mass,” said Monjardino.

Also Read- Poor Aerobic Fitness Increases Risk of Diabetes in Kids

“Our study results corroborate that there is no benefit in gaining weight above the US Institute of Medicine recommendations for pregnancy weight gain for children’s bone mass, in both normal and overweight women prior to pregnancy,” added Monjardino.

The team analysed prospective data from 2,167 mother-child pairs. (IANS)