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Gene showing opposite effect on some colorectal cancers

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New York: A gene that suppress the increase of many types of cancer is showing opposite effect in some forms of colorectal cancer, an Indian origin scientist said.

The research could lay the foundation for new colorectal cancer treatments.

“The gene is known as Sprouty2 has previously been shown to protect against metastasis, or the spreading of cancer to other parts of the body, in the breast, prostate and liver cancer,” said Sharad Khare, associate professor at University of Missouri School of Medicine in the US.

“However, our recent molecular studies found that this gene may actually help promote metastasis ( a spread of the disease to another organ) instead of suppressing it,” Khare noted.

For more than three years, Khare studied Sprouty2 in cancer cell models, mouse models and human biopsy samples.

Using different molecular methods, the researchers found that the gene functions differently in colorectal cancer than in other types of cancers.

Sprouty2 is known to block molecular circuits to prevent cancer cells from growing and spreading to other parts of the body.

However, the researchers found that in colorectal cancer, Sprouty2 may increase the ability of cancer cells to spread instead of suppressing it.

Khare believes this occurs when the gene is up-regulated or supercharged.

“This finding is a very significant step in our understanding of metastasis in colorectal cancer, but it’s important to note that we believe this phenomenon may occur in only a subset of colorectal cancer patients,” Khare said.

The findings appeared in the journal Oncogene.(IANS)(image:cellcan.com)

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Gut Microbiota Can Help Identify Liver Cancer: Researchers

Gut microbiota can help the body digest certain foods that the stomach and small intestine have not been able to digest.

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Liver Cancer
How gut microbiota can aid in early diagnosis of liver cancer.

Chinese researchers have identified gut microbiota as a new biomarker of liver cancer, that can help in early diagnosis as well as treatment of the condition.

Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the third leading cause of cancer-related death worldwide.

Due to the absence of specific symptoms in early stages and the lack of diagnostic markers, most patients with HCC are often diagnosed in an advanced stage.

Liver Cancer
AFP is a plasma protein that is produced in abundance by the liver cells. Pixabay

Researchers from China’s Zhejiang University, and Zhengzhou University, found that the microbial diversity in patients with cirrhosis was significantly lower than that in healthy people, but it increased when cirrhosis develops into cancer, the Xinhua reported.

Human gut microbiota has been considered the most important micro-ecosystem living with the body, containing tens of trillions of microorganisms, including at least 1,000 species of bacteria with more than 3 million genes.

Gut microbiota can help the body digest certain foods that the stomach and small intestine have not been able to digest.

Liver Cancer
A high-magnification image from a 2012 glioblastoma case is seen as an example in this College of American Pathologists image released from Northfield. VOA

For the study, appearing in the journal Gut, the team collected 486 fecal samples from across the country.

Also Read: Deaths Due to Cancer Increases to More Than 18 Mn Every Year: WHO

About 12 bacteria genera decreased and six increased in patients with early cancer compared with healthy people.

According to researchers, more data and further studies are needed to confirm the validity and reliability of the model. (IANS)