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Gene showing opposite effect on some colorectal cancers

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New York: A gene that suppress the increase of many types of cancer is showing opposite effect in some forms of colorectal cancer, an Indian origin scientist said.

The research could lay the foundation for new colorectal cancer treatments.

“The gene is known as Sprouty2 has previously been shown to protect against metastasis, or the spreading of cancer to other parts of the body, in the breast, prostate and liver cancer,” said Sharad Khare, associate professor at University of Missouri School of Medicine in the US.

“However, our recent molecular studies found that this gene may actually help promote metastasis ( a spread of the disease to another organ) instead of suppressing it,” Khare noted.

For more than three years, Khare studied Sprouty2 in cancer cell models, mouse models and human biopsy samples.

Using different molecular methods, the researchers found that the gene functions differently in colorectal cancer than in other types of cancers.

Sprouty2 is known to block molecular circuits to prevent cancer cells from growing and spreading to other parts of the body.

However, the researchers found that in colorectal cancer, Sprouty2 may increase the ability of cancer cells to spread instead of suppressing it.

Khare believes this occurs when the gene is up-regulated or supercharged.

“This finding is a very significant step in our understanding of metastasis in colorectal cancer, but it’s important to note that we believe this phenomenon may occur in only a subset of colorectal cancer patients,” Khare said.

The findings appeared in the journal Oncogene.(IANS)(image:cellcan.com)

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High carbohydrate intake may increase cancer recurrence risk

Five-year survival rates among these patients continue to be low, in part because these cancers are often detected in the later stages

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Can sugar contribute to growth of cancer in your body? Pixabay

Consuming high amounts of carbohydrates and sugar prior to treatment for head and neck cancer may increase the patients’ risks of cancer recurrence and mortality, a new study reports.

Patients who consumed the most total carbohydrates and sugars — in the form of sucrose, fructose, lactose and maltose — in the year preceding the cancer treatment were at greater risk of mortality from any cause during the follow-up period. Out of the 400 cancer patients in the study, published in the International Journal of Cancer, more than 17 per cent experienced recurrence of their cancer, and 42 patients died from it.

protein
Cancer can be caused by excessive intake of sugar and carbohydrates too. Pixabay

Associations among carbohydrate intake and patient outcomes differed by cancer type and stage, said lead author Anna E. Arthur, professor at the University of Illinois at Urbana-Champaign.

However, eating moderate amounts of fats and starchy foods such as whole grains, potatoes and legumes after treatment could have protective benefits, reducing the patients’ risks of disease recurrence and death, he added.

What We Know About Cancer Risk and Coffee

“Our results, along with the findings of other studies, suggest that diet composition can affect cancer outcomes,” said co-author Amy M. Goss, professor at the University of Alabama.

Higher mortality rates were found among people with oral cavity cancer who consumed the greatest amounts of total carbohydrates, total sugars and simple carbohydrates, but the researchers found no such associations among people who had oropharyngeal cancers.

Chronic diseases are not yet included in cancer prevention schemes.
Cancer can be caused due to too much sugar.

“Although in this study we found that higher total carbohydrate and total sugar were associated with higher mortality in head and neck cancer patients, because of the study design we can’t say that there’s a definitive cause-effect relationship,” Arthur said.

Five-year survival rates among these patients continue to be low, in part because these cancers are often detected in the later stages, putting patients at high risk of recurrence, the researchers said. IANS

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