Wednesday March 27, 2019

Gene Triggering Antibiotic Reaction Risk Identified, Says Study

"This observation also represents significant progress as we zero in on the mechanisms of these life-threatening immune-mediated drug reactions,"

0
//
genes
The study modified the levels of the protein encoded by a single gene known as GPR39.  Pixabay

Researchers have identified a gene that increases the risk of a severe and potentially life-threatening reaction to the commonly prescribed antibiotic vancomycin.

Vancomycin, used to treat serious and life-threatening bacterial infections, has been known to be a common antibiotic trigger for a severe reaction known as DRESS — Drug Rash with Eosinophilia and Systemic Symptoms.

The genetic risk factors predisposing specific patients were not known yet.

The new study, led by researchers from the Vanderbilt University in the US, showed that vancomycin triggers DRESS only in people carrying specific variations in human leukocyte antigen (HLA) genes.

DRESS has been characterised by fever, widespread skin rash and internal organ damage.

genes
Gene triggering antibiotic reaction risk identified. Pixabay

Routine testing for HLA gene could improve patient safety and reduce unnecessary avoidance of other antibiotics, said the study published in the Journal of Allergy and Clinical Immunology.

Since many patients who develop DRESS are often exposed to multiple antibiotics and other drugs simultaneously, the team used a specific diagnostic test developed in their laboratories called gamma-interferon ELISpot.

ELISpot exposed patients’ white blood cells to vancomycin and other concurrently administered antibiotics.This test enabled them to determine which drug was most likely causing DRESS.

Also Read- A Nap During The Day Can Lower High BP: Study

“This test will be important in the clinical care of patients starting vancomycin and will prevent mortality and short and long-term complications,” said Elizabeth Phillips, researcher at the varsity.

“This observation also represents significant progress as we zero in on the mechanisms of these life-threatening immune-mediated drug reactions,” she said. (IANS)

Next Story

China’s Researchers Find Antibiotic-Resistant Bacteria in Blood

The world is heading for a 'post-antibiotic' era if no action is taken, World Health Organization has warned. 

0
Vaccination, vaccine
Researchers have discovered new species of antibiotic-resistant bacteria in the blood of two patients in China, according to a recent study.

Researchers have discovered new species of antibiotic-resistant bacteria in the blood of two patients in China, according to a recent study.

The study showed that the patients were carrying unidentified species of Enterobacter huaxiensis and Enterobacter chuandaensis that did not respond to penicillin or the cephalosporin group of antibiotics.

Enterobacteriaceae exist in the gut and are usually harmless. However, they can cause meningitis if they enter the blood or pneumonia if they get into the lungs, reported Daily Mail.

RESEARCH
RESEARCH REPORTS.

The emergence of new species of antibiotic-resistant bacteria will make deadly infections harder to cure, with delays in treatment often leading to sepsis, according to scientists from Sichuan University in China.

Importantly, genetic analysis of the microorganisms revealed they were ‘previously unknown’, said the study published in the International Journal of Systematic and Evolutionary Microbiology.

In addition, the newly-discovered strains differed from other Enterobacteriaceae species by their ability to break down certain sugars and potassium salts.

Also Read: Nature Therapy Can Reduce Distress, Behavioural Problems in Kids

The world is heading for a ‘post-antibiotic’ era if no action is taken, World Health Organization has warned.

Pneumonia, tuberculosis, gonorrhoea and salmonellosis are among the growing number of infections that are becoming harder to treat. (IANS)