Monday May 28, 2018

Scientists Identified 80 Genes That Trigger Depression

Nearly 80 genes that could be linked to depression have been identified, a finding that adds to the evidence that it is partly a genetic disorder, say scientists. Depression, a common mental disorder, is the leading cause of ill health and disability worldwide.

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Suspension may lead to depression.
Suspension may lead to depression. Pixabay
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Nearly 80 genes that could be linked to depression have been identified, a finding that adds to the evidence that it is partly a genetic disorder, say scientists.

Depression, a common mental disorder, is the leading cause of ill health and disability worldwide.

According to the latest estimates from the World Health Organisation (WHO), more than 300 million people are now living with depression, an increase of more than 18 per cent between 2005 and 2015.

“This study identifies genes that potentially increase our risk of depression, adding to the evidence that it is partly a genetic disorder,” said lead author David Howard, research fellow at the University of Edinburgh.

Some of the pinpointed genes are known to be involved in the function of synapses, tiny connectors that allow brain cells to communicate with each other through electrical and chemical signals, the researchers said.

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Old Woman. pixabay

The study could help explain why some people may be at a higher risk of developing the condition as well as help researchers develop drugs to tackle mental health conditions.

“The findings also provide new clues to the causes of depression and we hope it will narrow down the search for therapies that could help people living with the condition,” Howard added.

For the study, published in Nature Communications, the team scanned the genetic code of 300,000 people to identify areas of DNA that could be linked to depression.

The WHO has identified strong links between depression and substance use disorders and diabetes and heart disease.

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Depression is also an important risk factor for suicide, which claims hundreds of thousands of lives each year.

Lack of support for people with mental disorders, coupled with a fear of stigma, prevent many from accessing the treatment they need to live healthy, productive lives. (IANS)

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Depression in Males Can Reduce The Pregnancy Chances, says Study

Citing previous studies, the authors noted that 41 per cent of women seeking fertility treatments have symptoms of depression.

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Among couples being treated for infertility, depression in the male partner was linked to lower pregnancy chances, according to a study.
Depression in males can reduce the chances of pregnancy. Pixabay

Among couples being treated for infertility, depression in the male partner was linked to lower pregnancy chances, according to a study.

The study showed that couples in which the male partner had major depression were 60 per cent less likely to conceive and give birth than those in which the male partner did not have major depression.

On the other hand, depression in the female partner was not found to influence the rate of birth.

In addition, intake of a class of antidepressants known as non-selective serotonin reuptake inhibitors (non-SSRIs) was also linked to a higher risk of early pregnancy loss among females being treated for infertility, the study appearing in the journal Fertility and Sterility, noted.

However, SSRIs, another class of antidepressants, were not linked to pregnancy loss. Neither depression in the female partner nor the use of any other class of antidepressant were linked to lower pregnancy rates.

 

“Our study provides infertility patients and their physicians with new information to consider when making treatment decisions,” said Esther Eisenberg, at National Institutes of Health’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) in Maryland, US.

Among couples being treated for infertility, depression in the male partner was linked to lower pregnancy chances, according to a study.
On the other hand, depression in the female partner was not found to influence the rate of birth. Pixabay

Citing previous studies, the authors noted that 41 per cent of women seeking fertility treatments have symptoms of depression.

Another study of men seeking in-vitro fertilisation (IVF) treatments reported that nearly 50 per cent experienced depression.

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For the study, the team analysed data for 1,650 women and 1,608 men to evaluate the potential influence of depression in couples seeking non-IVF treatments.

Among the women, 5.96 per cent were rated as having active major depression, compared to 2.28 per cent of the men.

Women using non-SSRIs were roughly 3.5 times as likely to have a first-trimester pregnancy loss, compared to those not using antidepressants. (IANS)