Saturday March 23, 2019

Genes Tied to Obesity May Lower Risk of Diabetes

"Meanwhile, some lean or normal weight individuals develop diseases like Type-2 diabetes," Yaghootkar noted

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Diabetes
Representational image. Pixabay

Certain genetic factors may impact our body in intriguingly paradoxical ways. A team of scientists has identified 14 new genetic variations that were linked with higher Body Mass Index (BMI) but have the potential to lower risk of diabetes, lower blood pressure and lower heart disease risk.

According to researchers, it is because the location — around middle or round the liver — where surplus fat is stored could be genetically determined.

This location is more important than the amount when it comes to insulin resistance and risk of diabetes and other conditions.

“There are some genetic factors that increase obesity, but paradoxically reduce metabolic risk. It is to do with where on the body the fat is stored,” said Brunel Alex Blakemore, Professor at the Brunel University London.

The findings revealed that as they gain weight, people who carry these genetic factors store it safely under the skin, and so have less fat in their major organs such as the liver, pancreas and kidneys.

Diabetes
Representational image. Pixabay

“Directly under the skin is better than around the organs or especially, within the liver,” Blakemore added.

For the study, published in the journal Diabetes, the team examined more than 500,000 people aged between 37 and 73.

They used Magnetic Resonance Imaging (MRI) scans of these people’s waists to match where they stored extra fat with whether they showed signs of Type-2 diabetes, heart attack and risk of stroke.

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“There are many overweight or obese individuals who do not carry the expected metabolic disease risks associated with higher BMI,” explained Hanieh Yaghootkar from the University of Exeter in Britain.

“Meanwhile, some lean or normal weight individuals develop diseases like Type-2 diabetes,” Yaghootkar noted. (IANS)

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Cardiovascular Events Cause 58% Deaths Among Diabetics

The medicine likewise helps lower the amount of sodium in the body and reduce triglyceride levels and blood pressure

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Diabetes
Representational image. Pixabay

Fifty-eight percent of deaths among people with type 2 diabetes are due to cardiovascular events, a leading Mexican expert has said.

“Patients who live with this disease have a greater risk of premature death or disability derived from cardiovascular events,” Hector Sanchez Mijangos, President of the Mexican Diabetes Federation, told Efe news.

The specialist said that the high glucose levels associated with diabetes damage blood vessels, resulting in problems with blood pressure and vision, joint pain and other maladies.

Data from the World Health Organization indicate that more 442 million people suffer from type 2 diabetes.

Mexico’s Health Secretariat has found that while roughly 13 million inhabitants of the Aztec nation are living with diabetes, only half of those afflicted know they have the disease.

In 2015 alone, according to Mijangos, there were more than 98,000 premature deaths in Mexico related to diabetes and the average age of those who died was 66.7 years old.

Diabetes
Representational image. Pixabay

“This is regrettable, because these people could have lived roughly another 15 years,” he said.

According to the 2012 National Health and Nutrition Survey, only 25 percent of Mexicans suffering with diabetes are managing their condition adequately.

That figure illustrates “why our greatest challenge continues to be access and adherence to treatment”, Mijangos said.

Also Read- Researchers Discover Balance of Two Enzymes That May Help Treat Pancreatic Cancer

To improve treatment options, Mexican health authorities in January issued an approval for the use of canagliflozin, a drug that helps reduce the amount of blood glucose reabsorbed by the kidneys, which in turns causes more glucose to be eliminated through urination.

“With this medicine, a person can lose 100 milligrams of glucose per day as well as about 400 kilocalories (4,000 calories) a day, which also helps with weight loss,” Mijangos said.

The medicine likewise helps lower the amount of sodium in the body and reduce triglyceride levels and blood pressure.

A scientific trial involving more than 10,000 patients worldwide showed that when combined with conventional treatment, canagliflozin can reduce the incidence of cardiovascular events by up to 18 percent. (IANS)