Thursday, July 9, 2020
Home Life Style Health & Fitness Genetic Alteration Can Increase Risk of Developing Autism and Tourette's Syndrome

Genetic Alteration Can Increase Risk of Developing Autism and Tourette’s Syndrome

Some researchers also found that the ability of the Thalamic brain regions to communicate with other brain areas was impaired by the genetic deletion

Researchers have discovered how a Genetic Alteration that increases the risk of developing Autism and Tourette’s impairs brain communication.

People with a genetic deletion known as chromosome 2p16.3 deletion often experience developmental delay and have learning difficulties.

They are also around 15 times more likely to develop Autism and 20 times more likely to develop Tourette’s Syndrome, but the mechanisms involved are not completely understood.

Using brain imaging studies, neuroscientists showed that deletion of the gene impacted by 2p16.3 deletion (Neurexin1) have impacts on the function of brain regions involved in both conditions.

This genetic deletion disrupts a brain area known as the Thalamus, compromising its ability to communicate with other brain areas, said the study published in the journal Cerebral Cortex.

“We currently have a very poor understanding of how the 2p16.3 deletion dramatically increases the risk of developing these disorders,” said lead researcher Neil Dawson of Lancaster University in Britain.

“However, we know that the 2p16.3 deletion involves deletion of the Neurexin1 gene, a gene that makes a protein responsible for allowing neurons to communicate effectively,” Dawson said.

Deletion of the Neurexin1 gene affects brain areas involved in Autism and Tourette’s including the Thalamus, a collection of brain regions that play a key role in helping other brain areas communicate with each other.

Autism
Researchers have discovered how a Genetic Alteration that increases the risk of developing Autism and Tourette’s impairs brain communication. Pixabay

Changes were also found in brain regions involved in processing sensory information and in learning and memory.

Importantly, the researchers also found that the ability of the Thalamic brain regions to communicate with other brain areas was impaired by the genetic deletion.

ALSO READ: Physical illness And injury Raises The Risk of Suicide in Men, Not Women: Study

They then tested the ability of a low dose of the drug Ketamine, which is used clinically at higher doses as an anesthetic, to normalise the alterations in brain function induced by genetic deletion.

“Intriguingly our data suggest that Ketamine can restore some aspects of the brain dysfunction that results from 2p16.3 deletion and suggests that ketamine, or other related drugs, may be useful in treating some of the symptoms seen in autism and Tourette’s,” Dawson said. (IANS)

STAY CONNECTED

18,993FansLike
362FollowersFollow
1,781FollowersFollow

Most Popular

‘HotShots’, TikTok-like Short Video App by Ganna

Joining the short-video making app race, music streaming service Gaana on Wednesday launched HotShots - a platform to create and share short viral videos...

Foods that will Help Improve Your Sleep

There is a strong correlation between sleep quality and dietary patterns. High intake of confectionary and noodles was associated with poor sleep quality, whereas...

Here’s How Remdesivir Can Save Lives in Nations with Lower Hospital Capacity

Amid news that the US has bought up virtually the entire global supply of remdesivir, a new study outlines how the drug could save...

Instagram brings TikTok-like Feature to India

With the ban on TikTok creating a huge vacuum for the 15-second videos in the Indian Internet space, Facebook-owned Instagram on Wednesday announced the...

Smartphones not a Barrier to Parenting: Research

Parents may worry that spending time on their smartphones has a negative impact on their relationships with their children, however, a new study found...

Meditation Increases Immunity, says Research

Heartfulness meditation improves immunity against infections and cancer and is an effective adjunct in the treatment of several autoimmune disorders, a study said. In the...

Here Are Some Precautions to Take While Dining Out Amid Pandemic

There is some risk, but health officials say there are precautions you can take to minimize the chances you'll be exposed to the virus. Ordering...

High BP Medications May Also Reduce Colorectal Cancer Risk

Researchers have now claimed that medications commonly prescribed to treat high blood pressure may also reduce patients' colorectal cancer risk. Angiotensin converting enzyme inhibitor (ACE-i)...

Recent Comments