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Genomics and genetic analysis are the most effective ways to manage cancer, not only in India but also across the globe.

Hereditary cancers are seen in approximately 10 per cent of the Western population, with a higher incidence in India. Hereditary cancer has high prevalence in breast and ovarian cancer patients. We see a very strong shift in this trend, with an increased incidence of cancer in India’s younger population. The section of the population that is at risk of hereditary cancer will certainly benefit from genetic analysis.


With genetic testing, we can understand the genetic profile of the cancer. This knowledge leads to choice of targeted drugs that are designed to counter the cellular functions of the mutant proteins. Patients on active chemotherapy regimens are reassured that they do have alternative directed treatments if they do not respond to the ongoing treatment regimen. In the long run, targeted therapeutics would replace generic chemotherapy.

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There is a great potential for targeted therapeutics. Cancer medicine, however, is evolving every day. There is much research and data to process and we still do not understand the full potential of genetic analysis and the benefits of targeted therapy based on the gene mutation. In such a scenario, if there is a targeted protein identified with effective medication available, then it would be better to treat the patient based on literature available after they have failed conventional treatment options.

New therapeutic drugs are being developed every year and their side effects are better controlled. Even though the cost of chemotherapy has drastically come down over time, targeted therapy has fewer side effects and causes lesser collateral damage to normal tissue. It is almost four to five times the cost of current chemotherapy regimens. As time progresses and these medications become generic, they would replace chemotherapy in the long run.

Genetic analysis of a tumour can support the choice of therapy at the initial stages of diagnosis as well as throughout the course of treatment. Cancer cells can mutate (change) and be present as a disease in multiple variant forms. This essentially means that we need a fresh “snapshot” of the genetic profile of each patient’s cancer at every stage of the disease. New target proteins are produced due to these mutations.

To introduce new drugs to target these changes, an understanding of the genetic profile of a cancer — quite like time-lapse photography to capture a sequence of events — is absolutely vital. Liquid biopsy is precisely the technique to use to achieve this.

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The challenge in this setting is getting the patient to understand the concept in the first place and then accept the increasing cost with the recurring tests. This process of longitudinal cancer care with follow-up liquid biopsies is already the norm in the United States. It makes sense scientifically, and insurance companies cover the cost. In the long run, liquid biopsy-based personalised cancer therapy will become the norm in India as well.

(Dr. Gurdeep Sethi is Founder, Millennium Cancer Center, Gurugram. Dr. Sudhir Borgonha is Chief Medical Officer, Strand Life Sciences, Bengaluru. The views expressed are personal. They can be contacted at setgu@gssmcc.com and sudhir@strandls.com) – IANS


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The aim of the book is to teach children that families can exist in different forms, and show them how to accept the diversity in family backgrounds.

By Siddhi Jain

Delhi-based author Pritisha Borthakur is set to release her new book, 'Puhor and Niyor's Mural of Family Stories'. The 1,404-word children's book was put together to address a new kind of societal debacle in the family system. The author says the aim is to teach children that families can exist in different forms, and show them how to accept the diversity in family backgrounds.

The author who named the book after her twin sons -- Puhor and Niyor -- is a parent who has seen and heard the tales of ridicule and discrimination suffered by many in India and beyond. She says the book is an artistic illustration for kids that details how different families can live and coexist. Whether it's children with two dads or two moms, children with a single dad or single mom, and even multiracial family units, Borthakur's book teaches love, understanding, and compassion towards unconventional families.

Beyond race, gender, color, and ethnicity which have formed the bases for discrimination since the beginning of time, this book aims to bring to light a largely ignored issue. For so long, single parents have been treated like a taboo without any attempt to understand their situations; no one really cares how or why one's marriage ended but just wants to treat single parents as villains simply for choosing happiness and loving their children.

Homosexual parents, a relatively new family system, is another form that has suffered hate and discrimination for many years. Pritisha emphasizes the need to understand that diversity in people and family is what makes the world beautiful and colourful. 'Puhor and Niyor's Mural of Family Stories' is a firm but compassionate statement against all forms of discrimination on the bases of sexual identity, gender, race, and even differences in background

four children standing on dirt during daytime 'Puhor and Niyor's Mural of Family Stories' is a firm but compassionate statement against all forms of discrimination on the bases of sexual identity, gender, race and even differences in background. | Photo by Ben Wicks on Unsplash


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Clean and maintained hands boost confidence in daily life activities.

If you feel that clean and well-groomed hands are just an essential prerequisite for women, you might like to think twice. Men should equally pay attention to their hands because our hand houses 1,500 bacteria living on each square centimeter of its skin. You can easily assume what havoc it can create in our body because in India we have the culture of eating with our hands and spaces beneath nails can become breeding heaven for germs. Moreover, clean and maintained hands boost confidence in their daily life activities. Therefore, it's important to keep your hands clean irrespective of your gender by washing or sanitizing at regular intervals. And, to keep them groomed, you don't have to visit a salon.

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* Refrain from harsh soaps: You should be mindful of the soap you are using to wash your hands. Your soap can have a moisturizing element in it like aloe vera or shea butter. Ensure that you're washing your hands with normal water as hot water can make your hand's skin dry and scaly.

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Bitcoin has become an essential crypto asset in modern portfolios and investment funds.

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Bitcoin will grow by a tenfold

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