Never miss a story

Get subscribed to our newsletter


×
Heavy drinking can change your DNA: Study

In a first, US researchers have identified a new genetic disorder, which was previously described in animal models, in a human patient.

Researchers from the Michigan State University found that the disorder is caused by mutations in a gene known as ornithine decarboxylase 1 (ODC1).


It is defined by a number of clinical features including large birth weight, enlarged head size, hair loss, reduced muscle strength, skin lesions, hearing loss and developmental delays.

“This remarkable case represents the first human example of a disorder that was described by researchers in a transgenic mouse model more than 20 years ago,” said Andre Bachmann, Professor at the varsity.

However, the disorder is, as of yet, unnamed, and its long-term effects, which include impacts on the neurological system, are not completely known.

The disorder was first identified on an 11-month-old baby girl in Michigan.

In the study, published in the American Journal of Medical Genetics Part A, blood samples for testing were drawn at age 19 months and 32 months.


Gene (Representational image). IANS

Two developmentally normal, age/gender matched patients that were being sedated for outpatient same-day procedures served as controls.

Red blood cells obtained from the patient showed elevated ODC protein and polyamine levels compared to healthy controls.

“The ODC1 gene plays an important role in a number of physiological and cell developmental processes including embryo and organ development,” said Caleb Bupp, medical geneticist at Spectrum Health — a US-based health care company.

The study also showed that the ODC inhibitor DFMO — a water soluble — and US Food Drug Administration (FDA)-approved drug may serve as a disease-modifying drug, and an early therapeutic trial in a new diagnosis may prevent some of the clinical symptoms.

Also Read- Breast Milk Boosts Brain Development in Premature Babies

DFMO has been used for many years in the treatment of trypanosomiasis — a tropical disease transmitted by biting insects and more recently entered clinical trials for pediatric neuroblastoma and colon cancer.

In mice, DFMO prevented hair loss and also partially restored hair growth and is considered a well-tolerated drug.

The original ODC1 mouse model was developed by Thomas G. O’Brien in 1995 at the Lankenau Medical Research Centre in Pennsylvania. (IANS)


Popular

Wikipedia

Set up in 1958 as the country's second IIT -- after IIT Kharagpur (IIT-KGP, 1950) in the list of 23 IITs currently, IIT-B enters the momentous diamond jubilee year of its historic first convocation held on December 22, 1962.


Set up in 1958 as the country's second IIT -- after IIT Kharagpur (IIT-KGP, 1950) -- in the list of 23 IITs currently, IIT-B enters the momentous diamond jubilee year of its historic first convocation held on December 22, 1962, when around 70 wide-eyed young men passed out of the institute.

Decades later, the golden jubilee convocation in 2012 was attended by then Prime Minister Manmohan Singh. The institute has a little more than 12,005 students in 2021, as per the current annual report released by its Director, Professor Subhasis Chaudhuri.

Keep Reading Show less
Unsplash

A laser show and fireworks will light up all temples, streets, 'crossroads' and other public places in Varanasi.

With the inauguration of Kashi Vishwanath corridor in Varanasi on December 13, the whole of Uttar Pradesh will be lit up similar to Diwali-like celebrations. This year the people of the state will invoke Lord Shiva in their homes by lighting lamps on the occasion of the inauguration of Kashi Vishwanath corridor, the highest revered shrine of Hindu faith. Along with this, a laser show and fireworks will light up all temples, streets, 'crossroads' and other public places in Varanasi.

Follow NewsGram on Facebook to stay updated.

Keep Reading Show less
Unsplash

The Prime Minister said that fully digital banks, without any physical branch offices, are already a reality and may become commonplace in less than a decade.

Prime Minister Narendra Modi on Friday said India's digital public infrastructure solutions can improve the lives of citizens around the world.

Speaking at the InFinity Forum organised by Bloomberg and IFSCA, he said via video link: "We believe in sharing our experiences and expertise with the world and learning from them as well."

Keep reading... Show less