Monday June 18, 2018

Girls may inherit ovarian cancer gene from fathers

The researchers collected information about pairs of granddaughters and grandmothers and sequenced portions of the X-chromosome from 186 women affected by cancer

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A mutation on the X-chromosome may also advance ovarian cancer's age of onset by more than six years. Wikimedia Commons
A mutation on the X-chromosome may also advance ovarian cancer's age of onset by more than six years. Wikimedia Commons
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Scientists have found a gene responsible for ovarian cancer that can be passed down from fathers to their daughters.

The study found that genes on the X-chromosome get potentially passed down through the father to his daughter, thus increasing the risk of ovarian cancer in girls.

A mutation on the X-chromosome may also advance ovarian cancer’s age of onset by more than six years.

“Our study may explain why we find families with multiple affected daughters: because a dad’s chromosomes determine the sex of his children, all of his daughters have to carry the same X-chromosome genes,” said Kevin H.

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Eng, Assistant Professor at Roswell Park Comprehensive Cancer Centre in Buffalo, the US.

The study, published in the journal PLOS Genetics, stated that the genetic mutation inherited from the paternal grandmothers were also associated with higher rates of prostate cancer in fathers and sons as well.

The study found that genes on the X-chromosome get potentially passed down through the father to his daughter, thus increasing the risk of ovarian cancer in girls. Wikimedia Commons
The study found that genes on the X-chromosome get potentially passed down through the father to his daughter, thus increasing the risk of ovarian cancer in girls. Wikimedia Commons

The researchers collected information about pairs of granddaughters and grandmothers and sequenced portions of the X-chromosome from 186 women affected by cancer.

The results proposed that a gene on the X-chromosome may contribute to a woman’s risk of developing ovarian cancer, independently of other known susceptibility genes, such as the BRCA genes.

This observation suggests that there may be many cases of seemingly sporadic ovarian cancer that are actually inherited, and may lead to improved cancer screening and better genetic risk assessment.

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However, future studies will be needed to confirm the identity and function of this gene.

“What we have to do next is make sure we have the right gene by sequencing more families. This finding has sparked a lot of discussion within our group about how to find these X-linked families,” Eng said.

“It’s an all-or-none kind of pattern: A family with three daughters who all have ovarian cancer is more likely to be driven by inherited X mutations than by BRCA mutations,” Eng noted. (IANS)

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California Cuts Coffee Off From Cancer Causing Chemicals

The state’s action rejects that ruling.

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A posted Proposition 65 warning sign is seen on display at a coffee shop in Burbank, Calif., March 30, 2018.
A posted Proposition 65 warning sign is seen on display at a coffee shop in Burbank, Calif., March 30, 2018. VOA

California officials, having concluded coffee drinking is not a risky pastime, are proposing a regulation that will essentially tell consumers of America’s favorite beverage they can drink up without fear.

The unprecedented action Friday by the Office of Environmental Health Hazard Assessment to propose a regulation to clear coffee of the stigma that it could pose a toxic risk followed a review of more than 1,000 studies published this week by the World Health Organization that found inadequate evidence that coffee causes cancer.

The state agency implements a law passed by voters in 1986 that requires warnings of chemicals known to cause cancer and birth defects. One of those chemicals is acrylamide, which is found in many things and is a byproduct of coffee roasting and brewing present in every cup of joe.

Win for coffee industry

If the regulation is adopted, it would be a huge win for the coffee industry, which faces potentially massive civil penalties after recently losing an 8-year-old lawsuit in Los Angeles Superior Court that could require scary warnings on all coffee packaging sold in California.

Judge Elihu Berle found that Starbucks and other coffee roasters and retailers had failed to show that benefits from drinking coffee outweighed any cancer risks. He had previously ruled the companies hadn’t shown the threat from the chemical was insignificant.

The state’s action rejects that ruling.

“The proposed regulation would state that drinking coffee does not pose a significant cancer risk, despite the presence of chemicals created during the roasting and brewing process that are listed under Proposition 65 as known carcinogens,” the agency said in a statement. “The proposed regulation is based on extensive scientific evidence that drinking coffee has not been shown to increase the risk of cancer and may reduce the risk of some types of cancer.”

A barista pours steamed milk into a cup of coffee at a cafe in Los Angeles, Sept. 22, 2017. State health officials proposed a regulation change Friday that would declare coffee doesn't present a significant cancer risk, countering a California court ruling.
A barista pours steamed milk into a cup of coffee at a cafe in Los Angeles, Sept. 22, 2017. State health officials proposed a regulation change Friday that would declare coffee doesn’t present a significant cancer risk, countering a California court ruling. VOA

Unprecedented move

Attorney Raphael Metzger, who won the court case on behalf of The Council for Education and Research on Toxics, said he was shocked the agency would move to nullify the court decision and undermine its own report more than a decade ago that drinking even small amounts of coffee resulted in a significant cancer risk.

“The takeaway is that the state is proposing a rule contrary to its own scientific conclusion. That’s unprecedented and bad,” Metzger said. “The whole thing stinks to high hell.”

The National Coffee Association had no comment on the proposed change. In the past, the organization has said coffee has health benefits and that the lawsuit made a mockery of the state law intended to protect people from toxics.

Scientific evidence on coffee has gone back and forth over many years, but concerns have eased recently about possible dangers, with some studies finding health benefits.

Big Coffee didn’t deny that acrylamide was found in the coffee, but argued it was only found at low levels and was outweighed by other benefits such as antioxidants that reduce cancer risk.

Coffee beans
Coffee beans, Pixabay

Congress

The state agency’s action comes about a week after bipartisan bills were introduced in both houses of Congress to require science-based criteria for labels on food and other products. One of the sponsors, Rep. Kurt Schrader, D-Oregon, alluded to the California coffee lawsuit as an example of misleading warnings.

“When we have mandatory cancer warnings on a cup of coffee, something has gone seriously wrong with the process,” Schrader said in a news release. “We now have so many warnings unrelated to the actual health risk posed to consumers, that most people just ignore them.”

The lawsuit against Starbucks and 90 companies was brought by the tiny nonprofit under a law that allows private citizens, advocacy groups and attorneys to sue on behalf of the state and collect a portion of civil penalties for failure to provide warnings.

The Safe Drinking Water and Toxic Enforcement Act, better known as Proposition 65, requires warning labels for about 900 chemicals known to cause cancer or birth defects.

Also read: What Does Your Coffee Say About You?

The law has been credited with reducing cancer-causing chemicals, but it has been criticized for leading to quick settlement shakedowns and vague warnings that are often ignored. (VOA)