Sunday September 23, 2018

Here’s How Gold-plated Nanoparticles can Help in Detection of Cancer at an Early Stage

Moreover, the new diagnostic technique costs less and is faster than traditional methods

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Cancer
Cancer Ribbon. Pixabay
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Researchers have developed a novel, low-cost finger prick blood test that deploys gold-plated nanoparticles for early detection of cancer.

The research team from the University of New South Wales (UNSW) in Sydney used nanoparticles to latch on to the targeted microRNAs (miRNAs), even in ultralow levels, which enabled them to be easily extracted.

“We are detecting small molecules found in the blood which could also identify the type of cancer, while they are looking for rare cells that are responsible for the spread of cancer,” said Justin Gooding, Professor from the varsity.

In the study, published in the journal Nature Nanotechnology, the team reported modifying gold-coated magnetic nanoparticles (Au@MNPs) with DNA to match the miRNA they wanted to detect.

Gooding said the nanoparticles are, in effect, dispersible electrodes. When circulated through the blood they capture the miRNA before a magnet is used to recapture the nanoparticles with the newly attached microRNA.

“Now we get more of the microRNA because the dispersible electrodes capture nearly everything in the sample,” Professor Gooding said.

Cancer
Cancer Ribbon. Pixabay

“Because the capture is so effective, we get higher sensitivities and can detect much lower limits.

“And since we bring them back to the electrode under a magnet, our response time is much faster,” he noted.

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Moreover, the new diagnostic technique costs less and is faster than traditional methods.

“Our method takes 30 minutes compared with almost 12 hours for quantitative polymerase chain reaction,” Gooding said.

Gooding said he expects the technology to be available within three years, pending regulatory approvals. (IANS)

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Gut Microbiota Can Help Identify Liver Cancer: Researchers

Gut microbiota can help the body digest certain foods that the stomach and small intestine have not been able to digest.

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Liver Cancer
How gut microbiota can aid in early diagnosis of liver cancer.

Chinese researchers have identified gut microbiota as a new biomarker of liver cancer, that can help in early diagnosis as well as treatment of the condition.

Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the third leading cause of cancer-related death worldwide.

Due to the absence of specific symptoms in early stages and the lack of diagnostic markers, most patients with HCC are often diagnosed in an advanced stage.

Liver Cancer
AFP is a plasma protein that is produced in abundance by the liver cells. Pixabay

Researchers from China’s Zhejiang University, and Zhengzhou University, found that the microbial diversity in patients with cirrhosis was significantly lower than that in healthy people, but it increased when cirrhosis develops into cancer, the Xinhua reported.

Human gut microbiota has been considered the most important micro-ecosystem living with the body, containing tens of trillions of microorganisms, including at least 1,000 species of bacteria with more than 3 million genes.

Gut microbiota can help the body digest certain foods that the stomach and small intestine have not been able to digest.

Liver Cancer
A high-magnification image from a 2012 glioblastoma case is seen as an example in this College of American Pathologists image released from Northfield. VOA

For the study, appearing in the journal Gut, the team collected 486 fecal samples from across the country.

Also Read: Deaths Due to Cancer Increases to More Than 18 Mn Every Year: WHO

About 12 bacteria genera decreased and six increased in patients with early cancer compared with healthy people.

According to researchers, more data and further studies are needed to confirm the validity and reliability of the model. (IANS)