Wednesday June 26, 2019

Here’s How Gold-plated Nanoparticles can Help in Detection of Cancer at an Early Stage

Moreover, the new diagnostic technique costs less and is faster than traditional methods

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Cancer
Cancer Ribbon. Pixabay

Researchers have developed a novel, low-cost finger prick blood test that deploys gold-plated nanoparticles for early detection of cancer.

The research team from the University of New South Wales (UNSW) in Sydney used nanoparticles to latch on to the targeted microRNAs (miRNAs), even in ultralow levels, which enabled them to be easily extracted.

“We are detecting small molecules found in the blood which could also identify the type of cancer, while they are looking for rare cells that are responsible for the spread of cancer,” said Justin Gooding, Professor from the varsity.

In the study, published in the journal Nature Nanotechnology, the team reported modifying gold-coated magnetic nanoparticles (Au@MNPs) with DNA to match the miRNA they wanted to detect.

Gooding said the nanoparticles are, in effect, dispersible electrodes. When circulated through the blood they capture the miRNA before a magnet is used to recapture the nanoparticles with the newly attached microRNA.

“Now we get more of the microRNA because the dispersible electrodes capture nearly everything in the sample,” Professor Gooding said.

Cancer
Cancer Ribbon. Pixabay

“Because the capture is so effective, we get higher sensitivities and can detect much lower limits.

“And since we bring them back to the electrode under a magnet, our response time is much faster,” he noted.

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Moreover, the new diagnostic technique costs less and is faster than traditional methods.

“Our method takes 30 minutes compared with almost 12 hours for quantitative polymerase chain reaction,” Gooding said.

Gooding said he expects the technology to be available within three years, pending regulatory approvals. (IANS)

Next Story

GRAIL Announces Significant Progress on Blood Tests to Detect Cancer

Grail's new results are from 2,300 people

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GRAIL, Blood Tests, Detect, Cancer
FILE A patient has her blood drawn at a hospital in Philadelphia to monitor her cancer treatment. VOA

A California company says its experimental blood test was able to detect many types of cancer at an early stage and gave very few false alarms in a study that included people with and without the disease.

Many companies are trying to develop early detection “liquid biopsy” tests that capture bits of DNA that cancer cells shed into blood.

GRAIL, Blood Tests, Detect, Cancer
A California company says its experimental blood test was able to detect many types of cancer at an early stage. VOA

Grail’s new results are from 2,300 people. The test detected 55% of known cancers and gave false alarms for 1%. It also accurately suggested where the cancer may be about 90% of the time.

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The company gave results in news release Friday and will report them Saturday at a conference in Chicago. They have not been published or reviewed by other scientists. (VOA)