Wednesday August 15, 2018

Gout May Not Increase the Risk of Fracture as Believed Earlier

Gout is the most common form of inflammatory arthritis, caused by the build-up of urate crystals in a joint.

0
//
34
People with gout, a painful inflammatory arthritis, may not actually have an increased risk of fracture as earlier believed, show results of a new study.
Gout is the most common form of inflammatory arthritis, caused by the build-up of urate crystals in a joint. Pixabay
Republish
Reprint

People with gout, a painful inflammatory arthritis, may not actually have an increased risk of fracture as earlier believed, show results of a new study.

The findings, published in CMAJ (Canadian Medical Association Journal), contrast with those of previous studies, which found higher risk of fracture in people with gout.

Gout is the most common form of inflammatory arthritis, caused by the build-up of urate crystals in a joint.

It can result in severe pain and swelling in joints, most often the base of the big toe but also in other joints.

Gout is the most common form of inflammatory arthritis, caused by the build-up of urate crystals in a joint.
It was believed that gout can increase the risk of fracture in body, Pixabay

To better understand the links between gout and fracture risk, the researchers from Keele University conducted a study in Britain using a large primary care database.

It included 31,781 patients with gout who were matched to 122,961 controls and followed them for between 6.8 and 13.6 years until the first diagnosis of a fracture.

Read About Osteoporosis: Drug Used For Osteoporosis May Help in Reducing Heart Attack Risk

The rate of fracture was similar in people with and without gout, the findings showed.

In addition, medication to lower urate levels in people with gout did not appear to benefit or adversely affect the long-term risk of fractures.

“Our use of a nationally representative cohort should enable our study findings to be generalisable not only to the UK but also to other countries with similar health care systems,” said Zoe Paskins from Keele University. (IANS)

Click here for reuse options!
Copyright 2018 NewsGram

Next Story

Study: Gout May Increase Dementia Risk in Elderly

Gout -- a very common condition -- is caused by deposits of crystals of a substance called uric acid (also known as urate) in the joints, which leads to inflammation

0
dementia
The researchers believe that this type of low intensity sound therapy may benefit humans. (IANS)

Elderly people suffering from gout may have 17-20 per cent higher risk of dementia, suggests a new study by a team that includes an Indian-origin researcher.

Gout — a very common condition — is caused by deposits of crystals of a substance called uric acid (also known as urate) in the joints, which leads to inflammation.

Periods of time when patients are experiencing gout symptoms are called flares. Flares can be unpredictable and debilitating, developing over a few hours and causing severe pain in the joints.

“Our study found a considerable increased risk of dementia associated with gout in the elderly,” said co-author Jasvinder Singh, a Professor of Medicine and Epidemiology at the University of Alabama at Birmingham, in the US.

For the study, presented at the Annual European Congress of Rheumatology (EULAR 2018), the researchers included 1.23 million Medicare beneficiaries, of which 65,325 had incident dementia.

Dementia Risk to 50-year-olds With Raised Blood Pressure
Dementia Risk to 50-year-olds raises with Blood Pressure . Pixabay

In an analysis which was adjusted for various potential confounding variables including demographics, comorbidities and commonly used medications, the results showed that gout is independently associated with a significantly higher risk of dementia.

The association was larger in older age groups, females, black race, and people with higher medical comorbidity.

Subgroup analyses indicated that gout was associated with a significant 20-57 per cent increase in dementia in patients without key comorbidities; coronary artery disease (CAD), hyperlipidemia, cardiovascular disease, diabetes or hypertension.

Also Read: Study: Dementia Risk to 50-year-olds With Raised Blood Pressure

However, this was not the case in patients with each of these comorbidities, except in patients with CAD, the researchers said.

Guidelines for the treatment of gout recommend lowering uric acid levels, although maintaining too low levels is a concern because uric acid is thought to protect the brain, they added.

“Further study is needed to explore these relationships and understand the pathogenic pathways involved in this increased risk,” Singh noted. (IANS)