Wednesday March 20, 2019

Gut Bacteria Has The Ability To Contribute to Diabetes

"Our findings show clearly how important the interaction between gut microbiota and diet is to understand our metabolism in health and disease," said Backhed

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Diabetes
Representational image. Pixabay

Gut bacteria has the ability to affect how cells respond to insulin and can thus contribute to Type-2 diabetes, says a new study.

The study explored that the gut microbiota of people with treatment-naive Type-2 diabetes can be linked to a different metabolism of the amino acid histidine, which is mainly derived from the diet.

This in turn leads to the formation of imidazole propionate, a substance that impairs the cells’ ability to respond to insulin. Therefore, reducing the amount of bacterial-produced imidazole propionate could be a new way of treating patients with such disease.

“This substance does not cause all Type-2 diabetes, but our working hypothesis is that there are sub-populations of patients who might benefit from changing their diet or altering their gut microbiota to reduce the levels of imidazole propionate,” said Fredrik Backhed, Professor at the University of Gothenburg in Sweden.

Diabetes
Representational image. Pixabay

For the study, published in the journal Cell, the research team involved 649 participants.

They used fecal samples and found that the microbiota of people with Type-2 diabetes produced imidazole propionate when histidine was added. However, this mechanism was not found in the diabetes-free control subjects.

Also read- Nearly 40 Individual HPV Types Linked to HIV Infection

“Our findings show clearly how important the interaction between gut microbiota and diet is to understand our metabolism in health and disease,” said Backhed.

The result also shows that gut bacteria from different individuals can lead to the production of completely different substances that may have very specific effects in the body,” he noted. (IANS)

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Joint Surgery May Spike up Blood Sugar Levels in Diabetics

Haemoglobin A1c above 6.59 for people with insulin-dependent diabetes and 6.6 without the condition was associated with an elevated risk for post-operative hyperglycemia

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Knee Joint. Pixabay.

People with diabetes who undergo joint replacement surgery are at higher risk of experiencing elevated blood sugar levels after the operation, increasing their chances of developing infections and other complications, a new study suggested.

Patients with insulin-dependent diabetes were more than five times as likely as those without the condition to develop hyperglycemia, or high blood sugar, after surgery, said researchers, including Bradford Waddell from the Hospital for Special Surgery (HSS) in the US.

“If your patient comes in with diabetes and is dependent on insulin, you need to be more cognizant of controlling their blood sugar in the perioperative period because they’re at higher risk,” said Waddell.

For the study, presented at the 2019 annual meeting of the American Academy of Orthopaedic Surgeons, the team reviewed medical charts of 773 men and women who had undergone total hip or knee replacement surgeries between 2011 and 2016.

Of those, 437 had insulin-dependent diabetes, while 336 had not the condition. It included patients with a diagnosis of diabetes whose blood sugar was being controlled using the hormone insulin and compared them with diabetics who did not require insulin.

Diabetes
Representational image. Pixabay

Patients requiring insulin can be considered to have more severe diabetes and have a greater chance of experiencing elevated blood glucose in the perioperative period, Waddell said.

Patients with higher blood glucose over the previous three months — as measured by Hemoglobin A1c — were more likely to experience post-operative hyperglycemia regardless of which group they were in.

Also Read- Excessive Hygiene Can Cause Antibiotic Resistance, Says Study

Hemoglobin A1c above 6.59 for people with insulin-dependent diabetes and 6.6 without the condition was associated with an elevated risk for post-operative hyperglycemia.

However, despite the increased risk for elevation in blood sugar after surgery, the incidence of post-operative joint infections did not differ between the two groups of patients. The author also noted that a limitation of the study was that it was underpowered to detect the risk of infection. (IANS)