Monday December 9, 2019

Gut Bacteria Linked to Atherosclerosis, Which is Further Linked to Heart Attack

The researchers believe that the new finding could open the door for new treatment options for those patients with unexplained plaque build-up in the arteries.

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The study, published in the journal Atherosclerosis, noted that these differences could not be explained by diet or kidney function, pointing to a difference in the make-up of their intestinal bacteria.
Gut Bacteria, (Representational image). Pixabay

The gut microbiome plays an important role in an individual’s risk for atherosclerosis, one of the major causes of heart attack and stroke, says a study.

It is a disease in which plaque builds up in the arteries.

The researchers believe that the new finding could open the door for new treatment options for those patients with unexplained plaque build-up in the arteries.

In order to understand the role that bacteria in the gut may play in atherosclerosis, the researchers examined blood levels of metabolic products of the intestinal microbiome.

In order to understand the role that bacteria in the gut may play in atherosclerosis, the researchers examined blood levels of metabolic products of the intestinal microbiome.
Atherosclerosis causes Heart Attack, Pixabay

They studied 316 people from different groups of patients, including those with unexplained atherosclerosis, who do not have any traditional risk factors but still have high levels of plaque burden.

“What we found was that patients with unexplained atherosclerosis had significantly higher blood levels of these toxic metabolites that are produced by the intestinal bacteria,” said David Spence, Professor at Western University, London, Canada.

The researchers measured the build-up of plaque in the arteries using carotid ultrasound.

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The study, published in the journal Atherosclerosis, noted that these differences could not be explained by diet or kidney function, pointing to a difference in the make-up of their intestinal bacteria.

“The finding, and studies we have performed since, present us with an opportunity to use probiotics to counter these compounds in the gut and reduce the risk of cardiovascular disease,” said Gregor Reid, Professor at Schulich School of Medicine and Dentistry at Western University.

Repopulation of the intestinal microbiome is another novel approach to treatment of atherosclerosis that arises from this study, Spence added. (IANS)

 

 

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Cancer Patients Are More Prone To Death From A Stroke: Study

One explanation for the increased risk could be that many people who are diagnosed with cancer are in a 'prothrombotic' state, which means they are more likely to form a blood clot

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Stroke
Additionally, they found that among those diagnosed with Cancer before they turned 40, most Stroke occurred in people treated for brain tumors and lymphomas. Pixabay

People living with Cancer are more than twice as likely to die of a stroke, compared to the general population say researchers, adding that the risk increases with time.

Cancers of the breast, prostate or colorectum were the type most commonly associated with fatal stroke, said the study published in the journal Nature Communications.

According the researchers, previous research has shown that most cancer patients aren’t going to die of their cancer, they are going to die of something else.

“A stroke is one possibility. Our findings suggest that patients may benefit from a screening program to help prevent some of these early deaths from stroke, as well as help identify which patients we could target with those preventative efforts,” said study researcher Nicholas Zaorsky, Assistant Professor at Penn State University in the US.

For the findings, the researchers used data gathered from the National Cancer Institute’s Surveillance, Epidemiology and End Results (SEER) programme.

SEER includes data about cancer incidence, survival, treatment and age and year of diagnosis, and covers 28 per cent of the US population.

They used SEER data on more than 7.2 million patients who had been diagnosed with invasive cancer — cancer that has spread beyond the tissue in which it originally developed — between 1992 and 2015.

The researchers found that out of 7,529,481 cancer patients, 80,513 died of a stroke.

Males and females had equal chances of dying from a stroke, but those diagnosed with cancer at a younger age had a higher chance of a fatal stroke.

Stroke
People living with Cancer are more than twice as likely to die of a Stroke, compared to the general population say researchers, adding that the risk increases with time. Pixabay

Additionally, they found that among those diagnosed with cancer before they turned 40, most strokes occurred in people treated for brain tumors and lymphomas.

In patients diagnosed with cancer above the age of 40, fatal strokes were most commonly associated with cancer of the prostate, breast and colorectum.

One explanation for the increased risk could be that many people who are diagnosed with cancer are in a ‘prothrombotic’ state, which means they are more likely to form a blood clot, Zaorsky said.

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“That blood clot may then go to the lungs and cause a pulmonary embolism, for example, or cause a stroke if it goes to the brain,” Zaorsky added.

The researchers added that future studies could help pinpoint mechanisms and further establish the relationship between cancer and strokes. (IANS)