Tuesday October 23, 2018

Gut Bacteria Linked to Atherosclerosis, Which is Further Linked to Heart Attack

The researchers believe that the new finding could open the door for new treatment options for those patients with unexplained plaque build-up in the arteries.

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The study, published in the journal Atherosclerosis, noted that these differences could not be explained by diet or kidney function, pointing to a difference in the make-up of their intestinal bacteria.
Gut Bacteria, Pixabay
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The gut microbiome plays an important role in an individual’s risk for atherosclerosis, one of the major causes of heart attack and stroke, says a study.

It is a disease in which plaque builds up in the arteries.

The researchers believe that the new finding could open the door for new treatment options for those patients with unexplained plaque build-up in the arteries.

In order to understand the role that bacteria in the gut may play in atherosclerosis, the researchers examined blood levels of metabolic products of the intestinal microbiome.

In order to understand the role that bacteria in the gut may play in atherosclerosis, the researchers examined blood levels of metabolic products of the intestinal microbiome.
Atherosclerosis causes Heart Attack, Pixabay

They studied 316 people from different groups of patients, including those with unexplained atherosclerosis, who do not have any traditional risk factors but still have high levels of plaque burden.

“What we found was that patients with unexplained atherosclerosis had significantly higher blood levels of these toxic metabolites that are produced by the intestinal bacteria,” said David Spence, Professor at Western University, London, Canada.

The researchers measured the build-up of plaque in the arteries using carotid ultrasound.

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The study, published in the journal Atherosclerosis, noted that these differences could not be explained by diet or kidney function, pointing to a difference in the make-up of their intestinal bacteria.

“The finding, and studies we have performed since, present us with an opportunity to use probiotics to counter these compounds in the gut and reduce the risk of cardiovascular disease,” said Gregor Reid, Professor at Schulich School of Medicine and Dentistry at Western University.

Repopulation of the intestinal microbiome is another novel approach to treatment of atherosclerosis that arises from this study, Spence added. (IANS)

 

 

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Anaemia Drug Can Aid in Recovery After Heart Attack

However, further studies will be needed to confirm if the same benefits are seen in humans, they noted

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Heart Disease
Concern has often focused on the toxicity or carcinogenic properties of the metals, particularly at high doses. Pixabay

Drugs currently undergoing development to treat anaemia — lack of blood — could be repurposed to help prevent people with Type-2 diabetes from developing heart failure, according to a new research.

Researchers found that after a heart attack, a protein called HIF acts to help heart cells survive.

In people with diabetes, fats accumulate within the heart muscle and stop the HIF protein from becoming active. This means that a person is more likely to suffer lasting heart muscle damage, and develop heart failure after a heart attack.

“After a heart attack, people with Type-2 diabetes are more likely to develop heart failure more quickly, but we have not fully understood the reasons why that is the case,” said lead researcher Lisa Heather, research student at the University of Oxford in the UK.

“What we have shown with this research is that the metabolism of people with Type-2 diabetes means they have higher levels of fatty acids in the heart. This prevents signals going to the heart protective protein telling it to ‘kick-in’ after a heart attack,” she added.

Representational image.
Representational image. (IANS)

In the study, published in the Journal of the American College of Cardiology, the team treated diabetic rats with a drug known to activate the HIF protein, and were able to encourage the heart to recover after a heart attack.

However, these initial results suggest that several drugs known to activate HIF and currently undergoing phase-III clinical trials to treat people with anaemia, could potentially be given to people with diabetes, immediately after a heart attack in the future, the researchers said.

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“This research in rats has not only identified the mechanism that could explain why people with Type-2 diabetes have poorer outcomes after a heart attack, but also a practical way this might be prevented,” the researchers explained.

However, further studies will be needed to confirm if the same benefits are seen in humans, they noted. (IANS)