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Haryana’s Cancer Village Awaits State Attention

Last year, the district administration even invited a team of cancer specialists from the World Cancer Care Charitable Society (WCCCS)

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Cancer
Cancer Ribbon. Pixabay

Abdul Razzaq died of lung cancer last May. He was the fourth victim of cancer from a family that hails from Sakras village in Haryana’s most backward district, Nuh.

Before him, his three brothers — Bashir, Shahabuddin and Qayam Ali — lost their lives to cancer of chest, mouth and neck, respectively, within two and half years.

With over 50 cancer deaths reported in the past three years and 130 in the past 10 years, Sakras has gained the notoriety as the cancer hub of the region. There’s not a single family, which hasn’t lost a member to cancer, or a member of which isn’t making trips to hospitals in neighbouring Delhi or Rajasthan.

Most villagers blame the contaminated ground water, the only source of drinking water, for the epidemic. The region also lacks basic amenities like piped water, drainage and sanitation.

“Our village is one of the largest in Ferozpur Jhirka sub-town and has 28,000 plus population. Apart from the area near the drain, water is salty across the village. The villagers have dug borewells and installed submersible pumps next to drain to meet their daily water needs,” said Sameer Mohammad.

Villagers say the sewage from drain is contaminating the ground water, but they have no choice but to use it.

Former Sarpanch Fazaluddin Besar said the village had been witnessing cancer deaths for a while. But the number has risen alarmingly in the past three years. “I first brought it to the district administration’s notice in 2011 and the District Health Department even took samples of water from the village,” Besar said.

But the water samples failed to pass the test and the Health Department did not reveal results. “We have a strong suspicion that the ground water here is highly contaminated and toxic,” Besar said.

Cancer patient
Cancer patient.

Sarpanch Phool Chand said though teams of experts have been visiting the village to study reasons behind the high incidence of cancer, the district administration has taken no steps.

If the water was indeed contaminated, the district administration hadn’t bothered to install a community RO (reverse osmosis) water treatment system in the village, he said.

Chand ruled out the possibility of mobile towers being the cause of cancer cases. “In that case, there would be more patients of brain cancer. Most patients here have died from lung cancer and some from cancers of mouth and neck,” he said.

Last year, the district administration even invited a team of cancer specialists from the World Cancer Care Charitable Society (WCCCS).

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“We had a day-long camp at a local school. Our medical team took samples of seven types of cancer, like blood, lung, bones, mouth and brain, from around 700 villagers. A month later, we submitted our findings and recommendations to the district administration,” said Dr Dharmendra Dhillon, head of the WCCCS team.

“The district administration recently asked us to resubmit the report. We did it a fortnight back,” said Dr Dhillon.

“There are various reasons for cancer in the village, like contaminated drinking water, excessive use of pesticides, unhealthy living conditions and consumptions of non-organic food. It is for the district administration to do an in-depth study into the reasons,” Dr Dhillon said.

When contacted, Nuh Civil Surgeon Rajiv Batish said, “We are still analysing the WCCCS report to find the exact reasons for the disease.” (IANS)

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Tiny Bubbles In Body Better Than Chemotherapy, Research Suggests

Researchers have found that tiny bubbles in our body might potentially be used to treat cancer and could fight the disease better than chemotherapy

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Cancer, Treatment, Chemotherapy, Tiny Bubbles, Research
"What we've done is improve a therapeutic approach to delivering enzyme-producing genes that can convert certain drugs into toxic agents and target tumours." Pixabay

Researchers have found that tiny bubbles in our body might potentially be used to treat cancer and could fight the disease better than chemotherapy.

Healthy cells in our body release nano-sized bubbles that transfer genetic material such as DNA and RNA to other cells. It’s your DNA that stores the important information necessary for RNA to produce proteins and make sure they act accordingly.

According to the researchers, these bubbly extracellular vesicles (EV) could become mini treatment transporters, carrying a combination of therapeutic drugs and genes that target cancer cells and kill them.

The study, published in the journal Molecular Cancer Therapeutics, focused on breast cancer cells in mice.

“What we’ve done is improve a therapeutic approach to delivering enzyme-producing genes that can convert certain drugs into toxic agents and target tumours,” said the study’s lead author Masamitsu Kanada, Assistant Professor at the Michigan State University.

Cancer, Chemotherapy, Tiny Bubbles, Research, Treatment
A Caucasian female nurse smiles as she administers chemotherapy through a catheter to an African American male patient in a clinical setting. Wikimedia Commons

These drugs or prodrugs start out as inactive compounds. But once they metabolize in the body, they are immediately activated and can get to work on fighting everything from cancer to headaches.

Aspirin is an example of a common prodrug.

In this case, researchers used EVs, to deliver the enzyme-producing genes that could activate a prodrug combination therapy of ganciclovir and CB1954 in breast cancer cells.

Minicircle DNA and regular plasmid – two different gene vectors that act as additional delivery mechanisms for DNA – were loaded into the vesicles to see which was better at helping transport treatment.

This is known as a gene-directed enzyme, prodrug therapy.

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They found that the minicircle DNA was 14 times more effective at delivery and even more successful at killing cancerous tumours.

“Conventional chemotherapy isn’t able to differentiate between tumours and normal tissue, so it attacks it all,” Kanada said.

With EVs, treatment can be targeted and because of their compatibility with the human body, this type of delivery could minimize the risk of unwanted immune responses that can come with other gene therapies.

“If EVs prove to be effective in humans, it would be an ideal platform for gene delivery and it could be used in humans sooner than we expect,” Kanada added. (IANS)