Friday March 22, 2019

Attention! Your Heart May be at Risk of an Infection Due to High Manganese Consumption

According to researchers, manganese inactivates a key line of defence against pathogens: the innate immune system's reactive oxygen burst

Research bodies estimate that the number of fragments of dead cells in the bloodstream increase with higher levels of pollution. Pixabay

New York, September 23, 2017 : Higher intake of dietary manganese – an essential mineral found in leafy green vegetables, fruits and nuts — could lead to infection of the heart by a bacterium, researchers warned.

Staphylococcus aureus (“staph”) is the leading cause of bacterial endocarditis (infection of the inner lining of the heart chamber and heart valves) and the second most frequent cause of bloodstream infections.

As per the study, reported in the journal Cell Host and Microbe, most of the mice that consumed a high manganese diet — about three times more manganese than normal — died after infection with staph.

The researchers, led by Eric Skaar, professor at the Vanderbilt University in the US, found that excess manganese inactivates a key line of defence against pathogens: the innate immune system’s reactive oxygen burst.

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Normally, in response to staph, “neutrophils pour into the site of infection and blast the bacteria with reactive oxygen species,” Skaar explained. However, the excess manganese counters this blast.

“It’s striking that a single dietary change can inactivate one of the most powerful branches of innate immune defence and lead to fatal infection,” Skaar said.

“The human body does a wonderful job of regulating nutrient levels and a traditional Western diet has plenty of minerals in it. The idea of super-dosing nutrients needs to be given careful consideration,” he noted.

Another study, appearing in the journal NeuroToxicology, showed that excessive environmental exposure to manganese can result in neurotoxicity and lower intelligence quotient (IQ) scores in children.

Manganese — known to play a vital role in brain growth and development — is also used widely in the production of steel, alloys, batteries and fertilisers and is added to unleaded gasoline.

The findings showed that increased manganese in hair samples was significantly associated with decline in full-scale IQ, processing speed and working memory.

“Children may be particularly susceptible to the neurotoxic effects of ambient manganese exposure, as their brains are undergoing a dynamic process of growth and development,” said Erin Haynes, Associate Professor at the University of Cincinnati in the US. (IANS)


Next Story

Injecting Drugs May up Bacterial Heart Infections: Study

increase in the risk of infective endocarditis is consistent with the findings of other studies, but the observed timing of the increase was novel, the team said

Heart rate
Heart rate, Flickr

People who inject drugs may have a significant increase in the risk of infective endocarditis, a serious infection of the lining of the heart, possibly linked to increasing use of the opioid hydromorphone, a new study suggests.

“We observed a substantial increase in the risk of infective endocarditis among people who inject drugs, which is associated with hydromorphone’s increasing share of the prescription opioid market,” said researchers, including first author Matthew Weir from Western University, London, Ontario.

For the study, published in the Canadian Medical Association Journal, researchers looked at Ontario data on drug users from linked health administrative databases between April 2006 and September 2015.

There were 60,529 admissions to hospital of people who inject drugs and, of these, 733 had infective endocarditis linked to injecting drugs.

Although admission rates for people who inject drugs were stable over the study period, the risk of infective endocarditis increased from 13.4 admissions every three months (fourth quarter 2011) to 35.1 admissions every three months in the period afterwards.

Heart Disease
Even low exposure to arsenic, lead may up heart disease risk. Pixabay

Whereas the percentage of opioid prescriptions attributed to controlled-release oxycodone declined rapidly when it was removed from the market by its manufacturer in the fourth quarter of 2011, hydromorphone prescriptions increased from 16 per cent at the start of the study to 53 per cent by the end, the researcher said.

The team expected that an increase in risk of infective endocarditis would occur when controlled-release oxycodone was removed from the Canadian market; however, they found that the rise began before removal.

“Although our observations do not support our hypothesis that the loss of controlled-release oxycodone increased the use of hydromorphone, they do support our suspicion that hydromorphone may be playing a role in the increasing risk of infective endocarditis,” said co-author Michael Silverman from the varsity.

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The increase in the risk of infective endocarditis is consistent with the findings of other studies, but the observed timing of the increase was novel, the team said.

“Both the rise in this severe complication of injection drug use and the possible association with hydromorphone require further study,” the authors noted. (IANS)