Monday March 18, 2019

Common Heartburn Drug Linked to Kidney Disease Risk, Says Study

Patients who took only PPIs reported a kidney-related adverse reaction at a frequency of 5.6 per cent against 0.7 per cent for patients who took only histamine-2 receptor antagonists

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Kidney
Patients who took only PPIs reported a kidney-related adverse reaction at a frequency of 5.6 per cent against 0.7 per cent for patients who took only histamine-2 receptor antagonists. Pixabay

Intake of widely prescribed drugs to neutralise stomach acid by people with heartburn or stomach ulcers could be associated with increased risk of kidney disease, warns a study of over 40,000 patients.

The study, published in the Scientific Reports journal, showed patients who took proton pump inhibitors (PPIs) were more likely to experience kidney disease than those who took another type of drug used to dampen down acid production called H2 blockers.

The patients who took only PPIs were 28.4 times more likely to report chronic kidney disease, as well as acute kidney injury (4.2 times more likely), end-stage renal disease (35.5 times more likely) and unspecified kidney impairment (eight times more likely), said researchers including Ruben Abagyan, Professor from the University of California-San Diego.

According to the World Health Organisation, PPIs are essential medicines for many people, helping them to control symptoms that are often painful and disruptive to daily life.

Kidney Injury
Representational image. (IANS)
But Abagyan hopes this initial data will prompt healthcare providers to appropriately warn, educate and monitor patients who require PPIs, particularly if they are at an elevated risk for kidney disease and electrolyte abnormalities.

For the study, the team looked at a data of 43,000 patients who took PPIs and the control group, approximately 8,000 patients who took histamine-2 receptor blockers, such as Zantac or Pepcid, and no other medications.

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Patients who took only PPIs reported a kidney-related adverse reaction at a frequency of 5.6 per cent against 0.7 per cent for patients who took only histamine-2 receptor antagonists.

However, the researchers cautioned the study does not reveal absolute frequency of these kidney-related complaints for all people taking PPIs. A large, randomised, controlled clinical trial would be needed to show causality between PPI usage and absolute risk of kidney disease in humans. (IANS)

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Passive Smoking May Raise The Chances of Kidney Disease

The global health body states that of the seven million lives that tobacco claims worldwide each year, almost 900,000 are passive-smokers

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Besides affecting your heart and lungs, exposure to second-hand or passive smoking can also raise the chances of chronic kidney disease (CKD), which can lead to renal failure, warns a new study.

The findings showed that individuals with less or more than 3 days of exposure per week had nearly double the risk of having kidney disease when compared with participants with no second-hand cigarette exposure.

“Second-hand smoke exposure at home or in the workplace is still prevalent despite legislative actions prohibiting public smoking,” said Jung Tak Park from Yonsei University in Seoul.

“This exposure was found to be clearly related with CKD, even with less-frequent amounts of second-hand smoke exposure,” Park added.

Smoking pregnant lady outside hospital.

For the study, published in the Clinical Journal of the American Society of Nephrology, the team included 131,196 non-smokers and were classified into three groups: no-exposure, less than three days per week of exposure, and three or more days per week of exposure.

Cigarette smoking and exposure to second-hand smoking have been linked with higher risks of various diseases.

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According to the World Health Organisation (WHO), smoking tobacco is globally the second leading cause of heart diseases after high blood pressure.Nearly 12 per cent of cardiovascular deaths worldwide occur due to tobacco abuse and second-hand smoking.

The global health body states that of the seven million lives that tobacco claims worldwide each year, almost 900,000 are passive-smokers. (IANS)