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"People who depend on vision for their livelihood need to realise there could be long-lasting consequences from inadvertent overdosing on this vitamin," Rosen said. Pixabay

Researchers have found that severe vision loss from a self-pres
cribed high dose of over-the-counter(OTC) niacin is linked to injury of a specific cell type in a patient’s eye.

Niacin, also known as vitamin B3, is used for lowering hyperlipidemia or cholesterol and comes in prescription and over-the-counter forms; it can produce a rare toxic reaction called niacin-induced cystoid maculopathy, a form of retinal swelling.


“This study shows how dangerous large doses of a commonly used over-the-counter medication can be,” said lead investigator Richard Rosen from New York Eye and Ear Infirmary (NYEE) in US.

“People who depend on vision for their livelihood need to realise there could be long-lasting consequences from inadvertent overdosing on this vitamin,” Rosen said.


Niacin, also known as vitamin B3, is used for lowering hyperlipidemia or cholesterol and comes in prescription and over-the-counter forms; it can produce a rare toxic reaction called niacin-induced cystoid maculopathy, a form of retinal swelling. Pixabay

For the study, the research team reported on a 61-year-old patient who arrived at the hospital with worsening blurry vision in both eyes that began a month earlier.

The initial exam showed that the patient was almost legally blind, with best-corrected visual acuity of 20/150 in the right eye and 20/100 in the left eye.

The patient told doctors his medical history included significant hypertension and hyperlipidemia, but initially failed to disclose the extent of his self-prescribing.

Subsequently, he admitted to taking an extensive list of supplements, which included three to six grams of niacin daily for several months to reduce his risk of cardiovascular events and was unaware of the risk to his eyesight.

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He purchased the supplement at a drug store after a doctor told him he had high cholesterol.

The standard dosage is one to three grams a day with a maximum dose of six grams, but doctors typically warn against treating the condition with supplements purchased over the counter and prefer to prescribe and monitor an FDA-approved dose of niacin.

NYEE clinicians diagnosed the problem using several state-of-the-art technologies, including fluorescein angiography, optical coherence tomography (OCT), and multifocal electroretinography (MERG), to examine his retina for evidence of cellular damage and monitor his response to therapy.

The imaging allowed investigators to diagnose a rare toxic reaction called niacin-induced maculopathy.


“This study shows how dangerous large doses of a commonly used over-the-counter medication can be,” said lead investigator Richard Rosen from New York Eye and Ear Infirmary (NYEE) in US. Pixabay

The high dose of niacin led to cystoid macular edema of the retina, which is fluid in the macula (a small area in the center of the retina that produces detailed and centralised vision) that causes swelling.

The technology also allowed investigators to identify the cellular structures responsible for the patient’s condition.

The MERG recorded in this case showed reduced b-waves, which indicated that cells affected by the toxicity were the Muller cells, which span the depth of the retina like support columns.

Discontinuation of the vitamin reversed this effect and restored retinal function and electrical signals.

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This led investigators to demonstrate that the ‘Muller cells’ were the target of niacin toxicity, and the cause of niacin maculopathy. (IANS)


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Photo by GOI.

New Education Policy 2020

On the first day of the two-day meeting of BJP and Rashtriya Swayamsevak Sangh (RSS) leaders on Tuesday, discussions were held on important issues related to education and the National Education Policy-2020.

Apart from senior RSS leader Suresh Soni, representatives of various organisations associated with the Sangh Parivar -- working in the field of education -- were present in the meeting in New Delhi.

According to sources, Union Education Minister Dharmendra Pradhan, who attended the meeting on behalf of the government, shared information related to the National Education Policy-2020 and the government's policy on important issues related to the education sector. Pradhan also shared details of the efforts being made by the government in the field of education.

Discussions were also held regarding the impact of the situation arising out of Corona and how much it has affected the education sector.

In the meeting, the RSS leaders asked several questions and provided suggestions to the Union Minister regarding the education policy of the government.

According to the sources, RSS wants the policy to be implemented expeditiously. All aspects related to the policy were discussed in Tuesday's meeting.

On the second and the last day of the meeting on Wednesday, special issues related to education will be discussed in which representatives of various organisations of the Sangh, Union Ministers and several BJP leaders will be take part.

Meanwhile, in order to convey its point of view to the government on various issues, the Sangh keeps on calling such coordination meetings related to specific issues, in which RSS representatives -- working in that particular area -- provide feedback to the government. (IANS/JB)

Keywords: BJP, RSS, New Education Policy, Education, India


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