Tuesday June 18, 2019

Consuming Low-fibre, High-fat Diet Can Spike up Risk of Sepsis

The team also identified molecular markers in Western diet-fed mice that could be used as predictors or biomarkers for patients that are at high risk for severe sepsis or patients that may need more aggressive treatment

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Diet
A dish of steak and cheese pasta is ready to eat in Concord, N.H., June 9, 2014. Two major studies in 2018 provided more fuel for the debate around carbs and fats, yet failed to offer a resolution to the polarizing matter of the best way to lose weight. VOA

Consuming a Western diet, low in fibre and high in fat and sugar, can put you at increased risk of developing severe sepsis, researchers say.

The study, published in the journal Proceedings of the National Academy of Sciences, found mice that were fed the Western diet showed an increase in chronic inflammation, sepsis severity and higher mortality rates than mice that were fed a normal diet.

Sepsis is a potentially life-threatening condition caused by the body’s response to an infection. It can lead to shock and organ failure. It is one of the most common cause of death worldwide.

According to the researchers, including Brooke Napier from the Portland State University, the mice had more severe sepsis and were dying faster because of something in their diet, not because of the weight gain or microbiome, the body’s community of bacteria.

“The mice’s immune system on the Western diet looked and functioned differently. It looks like the diet is manipulating immune cell function so that you are more susceptible to sepsis, and then when you get sepsis, you die quicker,” Napier said.

Food , delivery, diet
Low-fibre, high-fat diet may up severe sepsis risk. Flickr

The researcher said the findings can help hospitals better monitor the diets of patients in the intensive care unit (ICU) since they are already the ones most likely to develop sepsis.

“If you know that a diet high in fat and sugar correlates with increased susceptibility to sepsis and increased mortality when those patients are in the ICU, you can make sure they’re eating the right fats and the right ratio of fats,” she said.

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“If you could introduce a dietary intervention while they are in the ICU to decrease their chances of manipulating their immune system in that way, you can somehow influence the outcome,” she added.

The team also identified molecular markers in Western diet-fed mice that could be used as predictors or biomarkers for patients that are at high risk for severe sepsis or patients that may need more aggressive treatment. (IANS)

Next Story

Sepsis Subtypes Identified, Different Remedies Stressed

A new study, by a team of researchers from University of Pittsburgh in the US, stresses the need of testing more therapies for the treatment of different types of sepsis

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Vaccine
Influenza leads to serious and potentially life-threatening complications such as pneumonia, sepsis and heart disease, the study noted. VOA

Sepsis is not a single syndrome but multiple distinct conditions much like cancer, suggest researchers.

Sepsis is a life-threatening condition when the body’s response to an infection damages its own tissues and organs. The disease accounts for over 6 million global deaths annually.

A new study, by a team of researchers from University of Pittsburgh in the US, stresses the need of testing more therapies for the treatment of different types of sepsis.

“For over a decade, there have been no major breakthroughs in the treatment of sepsis; the largest improvements we’ve seen involve the enforcing of ‘one-size fits all’ protocols for prompt treatment,” said lead author Christopher Seymour, Associate Professor at University of Pittsburgh.

“But these protocols ignore that all sepsis patients are not the same. For a condition that kills over 6 million people annually, that’s unacceptable. Hopefully, by seeing sepsis as several distinct conditions with varying clinical characteristics, we can discover and test therapies precisely tailored to the type of sepsis each patient has,” Seymour remarked.

Sepsis is not a single syndrome but multiple distinct conditions much like cancer, suggest researchers.

For the study, published in Journal of the American Medical Association, researchers used computer algorithms to analyse 29 clinical variables found in the electronic health records of over 20,000 patients.

They noted that the algorithm clustered the patients into four different sepsis types, described as — Alpha (most common type (33 per cent), patients with least organ dysfunction and lowest in-hospital death rate at 2 per cent; Beta: older patients, comprising 27 per cent, with the most chronic illnesses and kidney dysfunction; Gamma: similar frequency as beta, but with elevated measures of inflammation and primarily pulmonary dysfunction; and Delta: least common (13 per cent), but most deadly type, often with liver dysfunction and shock, and the highest in-hospital death rate at 32 per cent.

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“Intuitively, this makes sense — you wouldn’t give all breast cancer patients the same treatment. Some breast cancers are more invasive and must be treated aggressively,” said senior author Derek Angus, Professor at the University.

“The next step is to do the same for sepsis that we have for cancer — find therapies that apply to the specific types of sepsis and then design new clinical trials to test them,” Angus said. (IANS)