Sunday December 8, 2019

High Fibre Diet Can Cut The Risk of Diabetes, Hypertension: Study

The researchers found a high fibre diet is inversely related to cardiovascular risk factors and plays a protective role against cardiovascular disease

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Fibre Diet
According to guidelines from the National Institute of Nutrition and the Indian Council of Medical Research, the recommended dietary allowance (RDA) for Fibre Diet is 40gm/2000kcal. Pixabay

Indian researchers have found that patients with hypertension and Type 2 diabetes who consumed a high Fibre diet witnessed an improvement in their blood pressure, cholesterol and fasting glucose.

For the study, the research team from Care Well Heart and Super Specialty Hospital in Amritsar, investigated the relationship between a high fibre diet and its impact on cardiovascular disease risk factors.

“Comprehensive evaluation of etiological effects of dietary factors on cardiometabolic outcomes, their quantitative effects and corresponding optimal intakes are well-established,” said the study’s lead author Rohit Kapoor.

According to guidelines from the National Institute of Nutrition and the Indian Council of Medical Research, the recommended dietary allowance (RDA) for dietary fibre is 40gm/2000kcal.

Patients in this study had Type 2 diabetes and a calorie intake of 1,200-1,500kcal, causing their RDA for fibre to be 24-30gm.

The fibre intake of these patients was increased up to 20 to 25 per cent from the recommended allowances for them to be consuming a high fibre diet.

The study tracked 200 participants’ fibre intake for six months and included check-ups at the start of the study, three months and six months.

Participants were provided with diet prescriptions, which included detailed lists of different food groups with portion sizes in regional languages.

Fibre Diet
Indian researchers have found that patients with hypertension and Type 2 diabetes who consumed a high Fibre Diet witnessed an improvement in their blood pressure, cholesterol and fasting glucose. Pixabay

The researchers tracked participants’ fibre intake several ways, including having patients send photos of their meals on WhatsApp, which not only helped in knowing their fibre intake but also helped approximate portion sizes, and telephone calls three times a week during which detailed dietary recall was taken.

Participants on a high fibre diet experienced significant improvement in several cardiovascular risk factors, including a nine per cent reduction in serum cholesterol, 23 per cent reduction in triglycerides, 15 per cent reduction of systolic blood pressure and a 28 per cent reduction of fasting glucose.

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The researchers found a high fibre diet is inversely related to cardiovascular risk factors and plays a protective role against cardiovascular disease. (IANS)

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Genetic Variations Influence Risk of Developing Cancer: Study

Study found that variations in the regions that regulate the expression of oncogenes and tumour suppressor genes affect cancer risk

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Cancer
While minor genetic changes only have a small impact on Cancer risk, the variations analysed in this study are numerous and common in the population. Pixabay

Shedding new light on why some people develop cancer while others do not, a new study has found that a person’s risk of developing cancer is affected by Genetic variations in regions of DNA that do not code for proteins, previously dismissed as “junk DNA”.

This study, published in the British Journal of Cancer, shows that inherited cancer risk is not only affected by mutations in key cancer genes, but that variations in the DNA that controls the expression of these genes can also drive the disease.

The researchers believe that understanding how non-coding DNA affects the development of this disease could one day improve genetic screening for cancer risk.

And in the future, this could lead to new prevention strategies, or help doctors diagnose the disease earlier, when it is more likely to be treated successfully.

“What we found surprised us as it had never been reported before — our results show that small genetic variations work collectively to subtly shift the activity of genes that drive cancer,” said lead researcher of the study John Quackenbush, Professor at Harvard T.H. Chan School of Public Health in the US.

Genetic
Shedding new light on why some people develop Cancer while others do not, a new study has found that a person’s risk of developing cancer is affected by genetic variations in regions of DNA that do not code for proteins, previously dismissed as “junk DNA”. Pixabay

“We hope that this approach could one day save lives by helping to identify people at risk of cancer, as well as other complex diseases,” Quackenbush said.

The researchers investigated 846 genetic changes within non-coding stretches of DNA, identified by previous studies as affecting cancer risk.

These Single Nucleotide Polymorphisms (SNPs) are particular positions in the human genome where a single letter of the genetic code varies between people.

Unlike mutations in coding DNA, such as BRCA, that are rare but significantly raise a person’s risk of developing cancer, non-coding SNPs are relatively common in the population but only slightly increase cancer risk.

The team analysed whether there was a correlation between the presence of a particular SNP and the expression of particular genes.

In total, they looked at over six million genetic variants across 13 different body tissues.

Genetic
The researchers believe that understanding how non-coding DNA affects the development of this disease could one day improve genetic screening for cancer risk. Pixabay

They found that variations in the regions that regulate the expression of oncogenes and tumour suppressor genes affect cancer risk.

The study also revealed that these cancer-risk SNPs tend to be specifically located in regions that regulate the immune system and tissue-specific processes — highlighting the importance of these cellular processes to the development of cancer.

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“While minor genetic changes only have a small impact on cancer risk, the variations analysed in this study are numerous and common in the population,” said Emily Farthing, senior research information manager at British charity Cancer Research UK. (IANS)