Tuesday February 25, 2020

High Levels of Testosterone May Raise Heart Failure Risk in Men

For the study, researchers included almost four lakh men and women aged 40 to 75 years

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Heart rate
Heart rate, Flickr
Men with genetic predisposition to high testosterone levels could be at increased risk of developing blood clots and heart failure, a study has found.
The study, led by City University of New York researchers, aimed to determine whether endogenous testosterone has a causal role in blood clots (thromboembolism), heart failure and heart attack (myocardial infarction).
They found endogenous testosterone was positively associated with thromboembolism, heart failure, and myocardial infarction in men.
The findings, published by The BMJ, can also have implications for men who take testosterone supplements to boost energy levels and sex drive, said Mary Schooling, Professor at the varsity.
Endogenous testosterone can be controlled with existing treatments and could be a modifiable risk factor for thromboembolism and heart failure, she noted.
Heart Attack, women
Anti-inflammatory drugs may put you at heart attack risk.
Pixabay
“We need to be thinking of new directions for reducing heart disease and this is one way of doing it,” Schooling was quoted as saying to The Guardian.
She pointed out that statins, which are used to reduce the risk of heart attack and stroke, have been found to lower testosterone levels.
“To protect men we should be looking at treatments and lifestyles which are more on the side of keeping testosterone lower rather than higher,” she said.
For the study, researchers included almost four lakh men and women aged 40 to 75 years.
The associations were found less obvious in women. (IANS)

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Here’s Why Diabetes May be an Independent Risk Factor For Heart Failure

Diabetes is also a major risk factor for atherosclerosis and this eventually leads to blockage of coronary arteries

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Disease
According to health expert in India, if poorly controlled, diabetes leads to cardiomyopathy resulting in progressive deterioration of pumping capacity of heart. Pixabay

Heart problems are a common development for people with diabetes and now researchers have found that diabetes is an independent risk factor for the development of heart failure in the community dwelling population.

According to health expert in India, if poorly controlled, diabetes leads to cardiomyopathy resulting in progressive deterioration of pumping capacity of heart.

“Diabetes is also a major risk factor for atherosclerosis and this eventually leads to blockage of coronary arteries. This leads to heart attack or myocardial infarction,” Satish Koul, HOD and Director Internal Medicine, Narayana Superspeciality Hospital, Gurugram, told IANS. “Due to myocardial infarction, the heart muscle becomes weak and eventually heart fails as a pump leading to congestive heart failure,” Koul added.

According to the current study, published in the journal Mayo Clinic Proceedings, researchers evaluated the long-term impact of diabetes on the development of heart failure, both with preserved ejection fraction – a measurement of the percentage of blood leaving the heart with each contraction – and reduced ejection fraction.

They also looked at mortality in a community population, controlling for hypertension, coronary artery disease and diastolic function. From an initial group of 2,042 residents of Olmsted County in US, 116 study participants with diabetes were matched 1:2 for age, hypertension, sex, coronary artery disease and diastolic dysfunction to 232 participants without diabetes.

Over the 10-year follow-up period, 21 per cent of participants with diabetes developed heart failure, independent of other causes. In comparison, only 12 per cent of patients without diabetes developed heart failure. Cardiac death, heart attack and stroke were not statistically different in the study between the two groups.

The study shows that diabetes is an independent risk factor for the development of heart failure in the community dwelling population. Furthermore, the outcome data support the concept of a diabetic cardiomyopathy.

Heart Disease
Heart problems are a common development for people with diabetes and now researchers have found that diabetes is an independent risk factor for the development of heart failure in the community dwelling population. Pixabay

This research extends previous findings and demonstrates that even without a known cardiac structural abnormality and with a normal ejection fraction, diabetic patients are still at increased risk of developing heart failure as compared to their nondiabetic counterparts.

“The key takeaway is that diabetes mellitus alone is an independent risk factor for the development of heart failure,” said study senior author Horng Chen from Mayo Clinic in the US.

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“Our hope is that this study provides a strong foundation for further investigations into diabetes and heart failure. There is still much to learn and study in terms of this association and how to best diagnose and treat this condition,” Chen added. (IANS)