Saturday January 18, 2020

High Levels of Testosterone May Raise Heart Failure Risk in Men

For the study, researchers included almost four lakh men and women aged 40 to 75 years

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Heart rate
Heart rate, Flickr
Men with genetic predisposition to high testosterone levels could be at increased risk of developing blood clots and heart failure, a study has found.
The study, led by City University of New York researchers, aimed to determine whether endogenous testosterone has a causal role in blood clots (thromboembolism), heart failure and heart attack (myocardial infarction).
They found endogenous testosterone was positively associated with thromboembolism, heart failure, and myocardial infarction in men.
The findings, published by The BMJ, can also have implications for men who take testosterone supplements to boost energy levels and sex drive, said Mary Schooling, Professor at the varsity.
Endogenous testosterone can be controlled with existing treatments and could be a modifiable risk factor for thromboembolism and heart failure, she noted.
Heart Attack, women
Anti-inflammatory drugs may put you at heart attack risk.
Pixabay
“We need to be thinking of new directions for reducing heart disease and this is one way of doing it,” Schooling was quoted as saying to The Guardian.
She pointed out that statins, which are used to reduce the risk of heart attack and stroke, have been found to lower testosterone levels.
“To protect men we should be looking at treatments and lifestyles which are more on the side of keeping testosterone lower rather than higher,” she said.
For the study, researchers included almost four lakh men and women aged 40 to 75 years.
The associations were found less obvious in women. (IANS)

Next Story

Losing Weight May Increase Testosterone Levels in Men: Researchers

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Testosterone levels men
Men diagnosed with low testosterone levels should start losing weight. Lifetime Stock

For many men diagnosed with testosterone deficiency, losing weight can help increase testosterone levels, say researchers, adding that, specifically a low-fat diet may be associated with a small but significant reduction in testosterone.

“We found that men who adhered to a fat restrictive diet had lower serum testosterone than men on a nonrestrictive diet,” said study researcher Jake Fantus from University of Chicago in the US.

“However, the clinical significance of small differences in serum T across diets is unclear,” Fantus added.

For the study, published in the Journal of Urology, the research team analysed data on more than 3,100 men from a nationwide health study (the National Health and Nutrition Examination Survey, or NHANES).

Testosterone levels weight loss
A low fat-diet is associated with higher testosterone levels in men. Lifetime Stock

All participants had available data on diet and serum testosterone level.

Based on two-day diet history, 14.6 per cent of men met criteria for a low-fat diet, as defined by the American Heart Association (AHA).

Another 24.4 per cent of men followed a Mediterranean diet high in fruits, vegetables, and whole grains but low in animal protein and dairy products.

Only a few men met criteria for the AHA low-carbohydrate diet, so this group was excluded from the analysis.

The average serum testosterone level was 435.5 ng/dL (nanograms per deciliter).

According to the study, serum testosterone was lower in men on the two restrictive diets: average 411 ng/dL for those on a low-fat diet and 413 ng/dL for those on the Mediterranean diet.

The associations were adjusted for other factors that can affect testosterone, including age, body mass index, physical activity, and medical conditions.

After adjustment, the low-fat diet was significantly associated with reduced serum testosterone, although the Mediterranean diet was not.

Overall, 26.8 per cent of men had testosterone levels less than 300 ng/dL. Despite the difference in average testosterone levels, the proportion of men with low testosterone was similar across all diet groups.

The researchers noted that further studies will be needed to corroborate their findings, and to clarify the mechanism by which restrictive diets reduce testosterone.

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But due to the difficulties of large-scale dietary studies, definitive trials are unlikely to be performed, they said.

“Therefore, our data represent a valuable approach towards answering this important question,” the researchers concluded. (IANS)