Tuesday March 26, 2019

As Per Study, High-Risk HPV Lead to Increased CVD

For the study, researchers included 63,411 women aged 30 or older without CVD.

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Obesity leads to high CVB in women.
women with obesity were nearly two-thirds more likely to develop CVD. Pixabay

While human papillomavirus (HPV) have been linked to cancer, infection with high-risk strains of the virus might also increase the fear of cardiovascular disease (CVD), especially among women with obesity or other cardiovascular problems, according to a new research.

Certain strains of HPV are considered high risk because they can increase the probability of vaginal, vulvar, penile, mouth, throat and cervical cancers.

The study showed that women with high-risk HPV were 22 per cent more likely than uninfected women to develop cardiovascular disease.

High risk HPV contributes to CVD problems.
HPV are considered high risk as they develop CVD disease. Pixabay

In addition, women with obesity were nearly two-thirds more likely to develop CVD and those with metabolic syndrome and high-risk HPV were nearly twice as likely to develop the disorder, showed results published in Circulation Research: Journal of the American Heart Association.

Conversely, slightly more than 7 per cent of the women without CVD developed high-risk HPV infections.

Interestingly, women who smoked, consumed alcohol and reported being physically active were also more likely to have high-risk HPV. In contrast, higher education – college degree or more – was associated with a decreased likelihood of having high-risk HPV.

 

Fear of increased CVD disease is higher in obese women.
Women with obesity faces higher chances of CVD disease. Pixabay

“A better understanding of high-risk HPV as a risk factor for cardiovascular disease and possible combined effects of high-risk HPV, obesity and metabolic syndrome in increasing cardiovascular disease risk may help improve preventive strategies and patient outcomes,” said Seungho Ryu, Professor at Sungkyunkwan University in South Korea.

Further studies are required to identify specific high-risk HPV genotypes that may contribute to cardiovascular disease and to examine whether vaccine strategies to reduce high-risk HPV infection for cancer prevention may also help reduce CVD, suggested the study.

ALSO READ: Keep Obesity At Bay With Flaxseeds

For the study, researchers included 63,411 women aged 30 or older without CVD. (IANS)

Next Story

Researchers Discover Balance of Two Enzymes That May Help Treat Pancreatic Cancer

While still in the earliest stages, Newton hoped this information might one day aid pancreatic diagnostics and treatment

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Cancer
Cancer Ribbon. Pixabay

A new research has set the stage for clinicians to potentially use levels of a pancreatic cancer patient’s PHLPP1 and PKC enzymes as a prognostic and for researchers to develop new therapeutic drugs that change the balance of the two enzymes as a means to treat the disease.

The study, published on Wednesday in Molecular Cell, was led by Alexandra Newton, professor in the Department of Pharmacology at the University of California, San Diego, School of Medicine, and Timothy Baffi, a graduate student in her lab, Xinhua news agency reported.

The new study built on the team’s work in 2015 that found the enzyme PKC, which was believed in previous studies to promote tumour growth, actually suppressed it.

The latest study took the investigation a step further by uncovering how cells regulate PKC activity and discovered that any time an over-active PKC is inadvertently produced, the PHLPP1 “proofreader” tags it for destruction.

Cancer patient
Cancer patient.

“That means the amount of PHLPP1 in your cells determines your amount of PKC,” Newton said. “And it turns out those enzyme levels are especially important in pancreatic cancer.”

The team observed 105 pancreatic cancer tumours to analyze the enzyme levels in each one. About 50 per cent of patients with low PHLPP1/high PKC lived longer than five-and-a-half years.

Also Read- A Brain Circuit Can Help Reverse Craving for Liquor, Says Study

While still in the earliest stages, Newton hoped this information might one day aid pancreatic diagnostics and treatment.

Pancreatic cancer is caused by the abnormal and uncontrolled growth of cells in the pancreas, a large gland in the digestive system. It typically doesn’t show symptoms in the early stages. Sufferers tend to develop signs, such as back pain and jaundice, when it has spread to other organs. (IANS)