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Researchers, including one of Indian-origin, have found that there is a much higher risk of mortality faced by COVID-19 patients in intensive care, who have chronic kidney disease (CKD) or those who develop new (acute) kidney injury (AKI).
CKD is a type of kidney disease in which kidney function declines over a period of months to years, and is more common in older people.
AKI is an abrupt loss of kidney function that takes place over seven days or less and can have several causes, including the damage and inflammation caused by the Covid-19 virus itself.
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“To the best of our knowledge, this is the first comprehensive analysis of outcomes in critically unwell Covid-19 patients in the UK with kidney failure, particularly in patients with pre-existing chronic kidney disease,” said study author Sanooj Soni from Imperial College London in the UK.
For the study, published in the journal Anaesthesia, the research team examined the association between AKI and CKD with clinical outcomes in 372 patients with Covid-19 admitted to four regional intensive care units (ICUs) in the UK.
The average age of the patients was around 60 years, and 72 percent of them were male.
A total of 216 (58 percent) patients had some form of kidney impairment (45 percent developed AKI during their ICU stay, while 13 percent had pre-existing CKD), while 42 percent had no CKD or AKI.
The patients who developed AKI had no history of serious kidney disease before their ICU admission, suggesting that the AKI was directly related to their Covid-19 infection.
The authors found that patients with no kidney injury or disease had a mortality of 21 percent.
Want to read more in Hindi? Checkout: ग्लोबल पीपीई हब बनने के रास्ते पर भारत
Those with new-onset AKI caused by the Covid-19 virus had a mortality of 48 percent, whilst for those with pre-existing CKD (Stages 1-4) mortality was 50 percent.
In those patients with end-stage kidney failure (CKD stage 5), where they already required regular out-patient dialysis, mortality was 47 percent.
Mortality was greatest in those patients with kidney transplants, with six out of seven patients (86 percent) dying, highlighting that these patients are an extremely vulnerable group.
The investigators also examined the rates of renal replacement therapy, a form of hospital dialysis, due to Covid-19 in these ICU patients with kidney injury.
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Out of 216 patients with any form of kidney impairment, 56 percent of patients requiring renal replacement therapy, the researchers said.
The authors noted that mortality in patients with end-stage kidney failure and on dialysis, who normally have worse outcomes in many other diseases, was similar to that in patients with less severe kidney disease and Covid-19 associated AKI.
This finding may suggest that such patients benefit equally from ICU admission and thus the threshold for admission should be calibrated accordingly in any future Covid-19 surge.
“Our data demonstrate that kidney disease and failure in critically ill patients with Covid-19 are common, and associated with high mortality,” the authors noted. (IANS)
Actress Kangana Ranaut has talked about how her weight adjustments for her latest 'Thalaivii' that "messed up many things" in her body and left her with "permanent stretch marks". For her role in the film, based on the life of late Tamil Nadu Chief Minister and former actress J. Jayalalithaa, Kangana had to gain 20kg and undergo major physical transformation several times.
She took to Instagram to share her experience, detailing that doing all that over the six months period left her with "permanent stretch marks". "Gaining 20 kgs in 6 months and loosing it all within 6 months that too in my thirties messed up many things in my bodya I also have permanent stretch marks as well but art comes to life with a price and more often than not price is the artist him/herself," she wrote.
"Thalaivii" showcases the varied aspects of Jayalalithaa's life, tracing her journey as an actress at a young age to becoming the face of Tamil cinema, as well as the rise of the revolutionary leader who changed the course of the state's politics. Talking about her upcoming works, Kangana currently has 'Dhaakad'.
She is also shooting for her next 'Tejas', where she plays a fighter pilot. The Indian Air Force was the first of the country's defence forces to induct women into combat roles in 2016. The film takes inspiration from the landmark event. 'Tejas' is directed by debutant Sarvesh Mewara. The film will be RSVP's second film which pays a tribute to the Indian military after the immensely successful film "Uri: The Surgical Strike" which was released in January 2019. (IANS/ MBI)
Keywords: Kangana Ranaut, Thalaivii, bollywood, stretc marks, actress, tamil cinema
Signal's encrypted messaging app continues to be down on Monday after facing global outage on Sunday. The firm said it is working to fix it. "Hold tight, folks! Signal is currently down, due to a hosting outage affecting parts of our service. We're working on bringing it back up," the firm said in a tweet on Sunday.
The status website says the encrypted messaging app is "experiencing technical difficulties" and many people are also getting an in-app error message that says the same thing. Signal allows for secure and encrypted video, voice and text communication, but users are unable to send any messages.
According to Downdetector.com, users started reporting outages around 11:05 PM Eastern Standard Time and it appears to be affecting people around the world. Comments shared on Downdetector.com indicates that Signal was down for users from India, US, Germany, New Zealand, Netherlands, Australia, Brazil and many other countries.
"Down in Midwest USA. Signal was started by people connected to which secret 3-letter organization? (Look it up) Yep, that's right! An app disguised a privacy app to trick you into sharing more private information than you would with another messaging app," a user said. "I think Signal is having a rough day. Good luck, Team Signal. I'm sure you'll have it sorted out in a snap," said another. The encrypted messaging service has climbed to the top spot in the free apps category of the App Store in multiple countries, including India. (IANS/ MBI)
Keywords: Signal, app, encrypted, messages, outage, down
Apple has acknowledged an issue where the "unlock with Apple Watch" feature might not work with its new iPhone 13 devices and promised to fix this issue with an upcoming software update. "You might see 'Unable to Communicate with Apple Watch' if you try to unlock your iPhone while wearing a face mask, or you might not be able to set up Unlock with Apple Watch," the iPhone maker said in the support document.
This issue will be fixed in an upcoming software update. Until the update is available, you can turn off Unlock with Apple Watch and use your passcode to unlock your iPhone 13. To turn off Unlock with Apple Watch, go to Settings > Face ID & Passcode.
Earlier, multiple users found that they cannot unlock their iPhone 13 with the Apple Watch and instead received an error. User Monzilla88 on Reddit first reported the issue to the subreddit r/AppleWatch. They stated that both their iPhone 13 Pro and Apple Watch SE are up to date with the newest iOS and watchOS updates.
"Whenever I try to enable unlock with Apple Watch on my phone I get an error saying "Unable to communicate with Apple Watch," they posted. Monzilla88 claimed that they had tried unpairing and repairing, hard resetting both devices, turning on and off passcodes, but not no avail, the report said. More than 20 other users self-reported the same problem, with others noting that the feature works fine on iOS 15 on older models of iPhone, including the iPhone 11 Pro Max and the iPhone X. (IANS/ MBI)
Keywords: iPhone 13, apple, watch, issue, update, face lock