Get subscribed to our newsletter
Get interesting updates to your email inbox.
KAMPALA, UGANDA — Uganda has kickstarted a trial for the injectable HIV drugs cabotegravir and rilpivirine. Researchers and those living with HIV say the trial will likely end pill fatigue, fight stigma, improve adherence and ensure patients get the right dosage.
The two drugs have been in use as tablets. The World Health Organization last year licensed their use as injectables.
While the two injectables already went through trials in Europe and North America, this will be the first time they are tested in an African population for efficacy and safety in an African health care system.
Uganda is one of three African countries, along with Kenya and South Africa, which got approval from the WHO to carry out the trials. However, Kenya and South Africa have yet to acquire approvals to start their trials, expected by the end of the year.
Uganda and Kenya will both have three trial sites and there will be two in South Africa, with a total of 512 participants -- 202 from Uganda, 160 from Kenya and 150 from South Africa.
Dr. Ivan Mambule, the lead project researcher at the Joint Clinical Research Center, says participants will need one injection every two months.
"We are going to choose participants who are already on ART [anti-retroviral treatment] and are stable on ART. And we will randomize them to either continue on their normal treatment, which is the pill that they've been taking, or to switch them to this injectable. The injection is on the buttock," he expressed.
In this photo taken in Nov. 15, 2012 a patient, right, is attended to, at the US sponsored Themba Lethu, HIV/AIDS Clinic at the Helen Joseph hospital in Johannesburg, South Africa Image credit: VOA
Uganda has 1.4 million people living with HIV/AIDS. Barbara Kemigisa who is living with HIV and founded the Pill Power Foundation working with rural women, says the injectable drugs will increase adherence to treatment and ensure people get the right dosage.
"One of the things that affects adherence is the fact that people have to hide medicine. In the village, people are hiding medicine in the kitchen roof, in trees, in bushes, in a baby's shoe…If someone is wrapping the medicine in like five plastic bags and digs a hole in the garden and keeps the medicine there, by the time someone is taking that medicine, it's no longer medicine, it's poison," Kemigisa points out.
Nicholas Niwagaba, who has worked with young people living with HIV welcomes the trial, saying it will reduce the pill burden and fight stigma.
"Young people feel like, this is a lot of pills to take. Those who are on the first line, they will have to take one tablet a day. There are those who are on second line and they have to take more than one pill and they have to take it in the morning and in the evening. And of course, this requires you to have actually a balanced diet which is really a challenge for most of young people especially those from vulnerable communities," he says.
According to the WHO, there are 25.7 million people living with HIV in Africa. With only the pill currently available to manage the scourge, this injectable may come as a relief for people living with HIV/AIDS. (VOA/RN)
(This article is originally by Halima Athumani)
Keywords: HIV, WHO, Africa, Research, Uganda
The new variant of the coronavirus Omicron is a variant of "concern" not "despair," Brazil's Health Minister Marcelo Queiroga said, adding that the country's health system is prepared for an eventual new Covid-19 wave.
"It is not a variant of despair because we have health authorities committed to providing quality care to our population," the Minister said.
Follow NewsGram on Quora Space to get answers to all your questions.
A Brazilian citizen coming from South Africa was quarantined in the south American country after testing positive for Covid-19, since it was not known which variant had infected him, Xinhua news agency reported.
The first case of the Omicron variant was detected in South Africa and reported to the World Health Organization on November 24.
Also Read : Exercises to recover from COVID
The new variant has a number of previously unseen mutations, mainly in the spike protein the virus uses to invade human cells.
Over the weekend, Queiroga asked Brazilians to remain calm, saying that measures against the new variant are the same, and the main weapon against Covid-19 is vaccination.
Brazil had accumulated 22,080,906 Covid-19 cases and 614,278 deaths from the virus as of Sunday.
Keywords : new variant, covid, Omicron, Brazil, Health Minister, coronavirus, mutation, health system, country, vaccination.
- Drones To Deliver Vaccines, Medicines In Jammu - NewsGram ... ›
- New Strain Of Covid - NewsGram - Lens to India from Abroad ›
Amit Rai Jain, a Baghpat-based businessman, has found 16 coins made of silver and copper which have a bull and a horseman engraved on them.
He found the coins from a mound, known locally as the 'Katha mound' in Khekhra, close to the Delhi-Saharanpur highway, on Sunday.
Follow NewsGram on LinkedIn to know what's happening around the world.
Jain told reporters that some of the coins are from the late 12th century AD, which is the era of Rajput king Prithviraj Chauhan.
"I keep frequenting the area, which is rich in archaeological finds. This time, it revealed something considered fascinating in Indian numismatics. The coins which I found belong to a series of Rajput rulers who remained dominant in the region comprising Rajasthan, Haryana, and the western Gangetic plains from the eighth century to 12th century AD," he said.
Jain, is a member of the Culture and History Association, an organisation comprising historians from western Uttar Pradesh.
K.K. Sharma, head of the department of history, Multanimal Modi College, Modinagar, confirmed the antiquity of the coins.
Picture of some ancient coinsUnsplash
"This is an interesting find as the area remained with the Rajput kings for a couple of centuries. Horse and bull inscriptions on coins were quite common in those days. Horses used to be the primary vehicle of soldiers during battles and their depiction on coins is not a surprise. In fact, close to two dozen rulers between the seventh and 17th centuries used horses in some form or the other on their coins," he said.
Baghpat is well-known for the discovery of interesting historical artifacts, the most sensational being three chariots unearthed during the Archaeological Survey of India excavation held in Sinauli in June 2018, which marked the 'first-ever' physical evidence of Bronze Age chariots in India.
In 2006, Sinauli had revealed Harappan-era burial grounds where several discoveries were made such as that of painted grey ware pottery, skeletons, bronze swords, and copper vessels.
Keywords : ancient, coins, silver, copper, archaeological, kings, discovery, historical, artifacts, Uttar Pradesh, India, Rajput.
- Akita Inu and Floki Inu – The Clueless Canine Coins and HUH ... ›
- Shiba Inu, Evergrow and HUH Token: 3 cryptocurrencies to watch ... ›
With an aim to examine the wide-ranging narratives and the very definitions of the art of sculpture, Palette Art Gallery's forthcoming exhibition, 18 Dimensions - is a show dedicated to sculptures underlining the important works by 18 contemporary artists, who have made a significant impact on the Indian and Global art landscape.
Bringing a seductive edge to the visual arts, an element of pleasure to one's life and working environment, the exhibit is an effort to showcase a broad scope of contemporary sculpture from the abstract and the minimal to the popular, making socio-political commentary that is deeply contemplative and thought-provoking.
Follow NewsGram on Facebook to stay updated.
The show reflects on a large number of materials and methods from casting to the modes of assemblage as well as minimalism, conceptualism making visible the process of making in most of the works.
Also Read : What Remains, art exhibition at Kala Ghoda
Featuring over 18 artists, the intention is to present a range and variety of sculptural expressions and encourage viewer participation and physical engagement with artworks once again, as the city opens up to mobility from the studios of Arunkumar HG, Ashiesh Shah, Gigi Scaria, G. R. Iranna, L. N. Tallur, Narayan Biswas, Mrinalini Mukherjee, Manjunath Kamath, Pooja Iranna, Himmat Shah, Jagannath Panda, Rajesh Ram, Riyas Komu, Sangam Vankhade, Sumedh R, Subodh Gupta, Sudarshan Shetty, Valay Shende, Vibha Galhotra and Vipul Kumar, the exhibition studies their involvement with the influences probing the limits and possibilities inherent in a sculpture's inescapable three-dimensional physicality.
One of the highlights of the show includes a selection of the rare hemp works by artist Mrinalini Mukherjee. Known for her distinctly contemporary style and use of dyed and woven hemp fibre, she worked with an unconventional material in the world of sculpting. Her four-decade-long career was an exemplar of a practice dedicated to formulating a language that was a mix of abstraction and figuration.
Keywords : art gallery, sculpture, exhibition, Palette Art Gallery, Bikaner House, New Delhi, contemporary, abstract, materials, conceptualism.
- Capturing The Beauty Of Nature On Bottles With Art - NewsGram ... ›
- Horn Please! Beauty of Truck Art in Pakistan is more of a Cultural ... ›