Wednesday January 22, 2020

Here’s how HIV Patients Lose Immunity to Smallpox Despite of Vaccinations

HIV patients lose smallpox immunity despite vaccine says a new study by health experts

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HIV immune
The study found the immune systems of HIV-positive women who were on antiretroviral therapy had a limited response when their blood was exposed to the vaccina virus. Pixabay

HIV patients lose immunity to smallpox even though they were vaccinated against the disease as children and have had much of their immune system restored with anti-retroviral therapy, says a new study.

Antiretroviral therapy (ART) is the use of HIV medicines to treat HIV infection. It helps people with HIV live longer, healthier lives and reduces the risk of HIV transmission.

The study, published in the Journal of Infectious Diseases on HIV-associated immune amnesia could explain why people living with HIV still tend to have shorter lives on average than their HIV-negative counterparts despite being on antiretroviral therapy.

The study follows other research recently published in the journals Science and Science Immunology that found the immune systems of children who contracted measles similarly ‘forgot’ their immunity against other illnesses such as influenza.

Immune system
Researchers have found that HIV patients lose immunity to smallpox even though they were vaccinated against the disease. Pixabay

For the study, lead researcher Mark K. Slifka from Oregon Health and Science University in US, and his colleagues compared the T-cell and antibody responses of a total of 100 HIV-positive and HIV-negative women who were vaccinated against smallpox in their youth.

The research team chose smallpox because its last known US case was in 1949, meaning study participants haven’t recently been exposed to its virus, which would have triggered new T-cell and antibody responses.

They found the immune systems of HIV-positive women who were on antiretroviral therapy had a limited response when their blood was exposed to the vaccina virus, which is used in the smallpox vaccine.

Normally, those vaccinated against smallpox have CD4 T cells that remember the virus and respond in large numbers when they’re exposed again.

Previous research has shown smallpox virus-specific CD4 T cells are maintained for up to 75 years after vaccination.

This finding happened despite the fact that antiretroviral therapy works by boosting CD4 T cell counts in HIV-positive patients.

This indicates that while antiretroviral therapy may boost total T cell counts overall, it can’t recover virus-specific T cells generated from prior childhood vaccinations.

Also Read- HPV Vaccinations may Reduce Cervical Cancer Rate in Kenya

The research team plans to evaluate whether the same phenomenon occurs in HIV-infected men, and if people living with HIV also lose immune memory to other diseases.

Researchers from SUNY Downstate, Georgetown University, Cornell University, University of Southern California and John Hopkins University, also contributed to this study. (IANS)

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Promotional E-Cigarettes Posts on Instagram Outnumber Anti-Vaping Content: Study

E-cigarette popular on Instagram despite anti-vaping content

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e-cigarettes
Despite "The Real Cost" awareness campaign launched by the US Food and Drug Administration (FDA) in 2018, nearly one third of American teenagers are estimated to use e-cigarettes. Pixabay

Promotional e-cigarettes posts on popular photo-sharing platform Instagram outnumber anti-vaping content 10,000 to one, according to a new study and health news.

Despite “The Real Cost” awareness campaign launched by the US Food and Drug Administration (FDA) in 2018, nearly one third of American teenagers are estimated to use e-cigarettes, the researchers said.

The study, published in the journal Frontiers in Communication, highlights the limited impact of the FDA campaign, while also using deep learning – an artificial intelligence method – to better understand the marketing tactics used by vaping companies.

“US public health officials have been calling vaping among youth an epidemic and have been putting a lot of effort into trying to stop this epidemic by introducing #TheRealCost anti-vaping campaign but this stark imbalance in the volume of posts has caused the FDA message to be overwhelmed by marketing from the vaping brands,” said study researcher Julia Vassey from University of California in the US.

e-cigarettes
Many teenagers continue to view e-cigarettes as healthier than conventional cigarettes, but vaping is associated with inflammation, reduced immune responses and breathing troubles. Pixabay

Many teenagers continue to view e-cigarettes as healthier than conventional cigarettes, but vaping is associated with inflammation, reduced immune responses and breathing troubles, the study said.

To further understand how vaping is perceived on social media, research team collected 245,894 Instagram posts spanning from before and after the #TheRealCost campaign launch.

The team also conducted interviews with five vaping influencers and eight college-age social media users. “We focused on Instagram because the vaping influencers we interviewed for this study identified Instagram as their most important social media marketing platform,” Vassey explained.

“Based on the results, the FDA anti-vaping campaign is not very popular and we saw Instagram user comments disputing the FDA claims of damaging health effects from nicotine and calling the campaign propaganda,” Vassey added.

Also Read- Drugs That Treat Arthritis in Dogs Can Kill Cancer Cells: Study

In contrast to the FDA’s intentions, the study found that vaping posts received nearly three times more “likes” after the campaign launch. They also found that there were six times as many posts that had greater than 100 likes.

According to the researchers, participants in the focus groups suggested that the anti-vaping campaign promoted scare tactics rather than offering guidance on how to quit vaping. (IANS)