Friday November 16, 2018

HIV Drug Is Not Linked to Depression: Study

A new study of a popular HIV drug could ease concerns about its link to depression

0
//
HIV, Indonesia
A doctor draws blood from a man to check for HIV/AIDS at a mobile testing unit in Ndeeba, a suburb in Uganda's capital, Kampala. VOA
Republish
Reprint

A new study of a popular HIV drug could ease concerns about its link to depression. Researchers in Uganda found that efavirenz, once feared to lead to depression and suicide, did not cause the expected negative side effects in their patients.

Efavirenz is an affordable, once-a-day pill used around the globe to treat and prevent HIV/AIDS. It’s “the treatment of choice” in most of the world, according to Africa Health Research Institute’s Mark Siedner, “especially [in] countries that depend on global aid to treat HIV.”

But some fear that efavirenz may come with a cost.

Some studies in the United States and Europe found the drug increased patients’ risk of depression or suicide, although other studies did not.

The mixed results prompted many doctors in the United States to prescribe more expensive but potentially safer drugs.

Siedner wanted to take another look at the risk of depression, this time in an African population. From 2005 until 2015, he and a team of Ugandan and U.S. doctors tracked 694 patients who took either efavirenz or another antiretroviral medication. They regularly asked the patients whether they experienced depression or suicidal thoughts.

No difference

Their analysis, published in the Annals of Internal Medicine, showed there was no difference between the two treatments. Siedner told VOA, “In other words, efavirenz was not associated with a risk of depression. If anything, there seems to be a signal that potentially it was associated with a decreased risk. But it wasn’t a strong enough [signal] for us to say that.”

The authors also reported that of the 17 participants who died in the course of the study, not a single death was a suicide.

Siedner has two possible explanations for why their findings differed from those in Western countries. “One potential cause is that every single ethnic group in the world, of course, is different, and different in many different ways — different socially, different environmentally, and in this case they may be different genetically.” His team is looking at whether the genes that control metabolism of the drug have a role to play in this story.

HIV Aids is a deadly disease.
HIV virus is Not Linked To Depression. Flickr

A second explanation could be the effectiveness of the drug. Because efavirenz is so potent, it could be keeping people healthier than they expected, so patients are less likely to report negative emotions.

The study is important, said Anthony Fauci, who heads the National Institute of Allergy and Infectious Diseases, because it pushes back against “the initial observation of suicidal ideation and suicide and depression” as caused by efavirenz. He told VOA, “I think now what you’re seeing is that with these conflicting reports, it’s likely someone will come in [with] the proposal to do a randomized study and take a look. So the story isn’t ended with this paper.”

As more research on the safety of efavirenz is conducted, new and cheaper drugs that might replace it are on the horizon. One of them, dolutegravir, might also pose a risk, however. A study in Botswana found dolutegravir was linked to neural tube defects in embryos, meaning it might not be safe for pregnant women. As always, further research is needed to confirm whether this is a common problem or specific to the population studied in Botswana.

Also read: UNAIDS : World Is At A “Defining Moment” In A Battle Against HIV/AIDS

“I think the whole field right now is in a bit of a holding pattern,” Siedner said when asked about dolutegravir and the future of HIV medication. (VOA)

Click here for reuse options!
Copyright 2018 NewsGram

Next Story

Loneliness And Depression Can Be Linked to Social Media: Study

It is unclear if the depressing effects of social media will cross generational lines to older or younger people

0
Social Media,
This photo taken March 22, 2018, shows apps for WhatsApp, Facebook, Instagram and other social networks on a smartphone. VOA

University of Pennsylvania researchers say that for the first time they have linked social media use to increases in depression and loneliness.

The idea that social media is anything but social when it comes to mental health has been talked about for years, but not many studies have managed to actually link the two.

To do that, Penn researchers, led by psychologist Melissa Hunt, designed a study that focused on Facebook, Snapchat and Instagram.

The results were published in the November issue of the Journal of Social and Clinical Psychology.

Social media. Offensive Speech
An iPhone with Twitter, Facebook and other apps, May 21, 2013. U.S. internet companies are taking a harder look at their policies that have promoted free expression around the world.. VOA

How study worked

The study was conducted with 143 participants, who before they began, completed a mood survey and sent along photos of their battery screens, showing how often they were using their phones to access social media.

“We set out to do a much more comprehensive, rigorous study that was also more ecologically valid,” Hunt said. That term, ecologically valid, means that the research attempts to mimic real life.

The study divided the participants into two groups: The first group was allowed to maintain their normal social media habits. The other, the control group, was restricted to 10 minutes per day on each of the three platforms: Facebook, Snapchat and Instagram.

The restrictions were put in place for three weeks and then the participants returned and were tested for outcomes such as fear of missing out (FOMO), anxiety, depression and loneliness.

Social Media
Chiara Valenzano, right, photographs her food as she has lunch with her friend Giulia Terranova at the ‘This is not a Sushi bar’ restaurant, in Milan, Italy, Oct. 16, 2018. At the restaurant, payment can be made according to the number of Instagram followers one has. VOA

Results of study

The results showed a very clear link between social media use and increased levels of depression and loneliness.

“Using less social media than you normally would leads to significant decreases in both depression and loneliness,” Hunt said. “These effects are particularly pronounced for folks who were more depressed when they came into the study.”

She calls her findings the “grand irony” of social media.

What is it about social media that’s just so depressing?

Hunt says that it’s two major things. The first is that social media invites what Hunt calls “downward social comparison.” When you’re online, it can sometimes seem that “everyone else is cooler and having more fun and included in more things and you’re left out,” she said. And that’s just generally demoralizing.

Social Media
The study was conducted with 143 participants, who before they began, completed a mood survey Pixabay

The second factor is a bit more nuanced.

“Time is a zero-sum game,” Hunt told VOA. “Every minute you spend online is a minute you are not doing your work or not meeting a friend for dinner or having a deep conversation with your roommate.”

And these real life activities are the ones that can bolster self-esteem and self worth, Hunt said.

What to learn

So what’s the takeaway?

social media
A girl uses her mobile phone in Jakarta, Indonesia, July 5, 2017. A researcher in Britain says her findings suggest young girls who are more active on social media have lower levels of well-being in their teens. VOA

People are on their devices, and that’s not going to change, she said. But as in life, a bit of moderation goes a long way.

“In general, I would say, put your phone down and be with the people in your life,” she added.

Also Read: Childhood Violence May Spur Puberty, Depression: Study

Hunt pointed out a few caveats to the study. First, it was done exclusively with 18- to 22-year-olds, and it is unclear if the depressing effects of social media will cross generational lines to older or younger people, Hunt said. But she expects her results should generalize at least for people through the age of 30.

Hunt says she is now beginning a study to gauge the emotional impact of dating apps. (VOA)