Never miss a story

Get subscribed to our newsletter


×
Age-related muscle loss, called sarcopenia, is a natural part of aging. After age 30, you begin to lose as much as 3% to 5% per decade. Most men will lose about 30% of their muscle mass during their lifetimes. Unsplash

Researchers have found that the hormone, ghrelin, may help protect the elderly population from muscle loss. The study, presented at e-ECE 2020 online conference on Tuesday, found that administering a particular form of ghrelin to older mice helped to restore muscle mass and strength.

“As muscle-related diseases are a serious health concern in the elderly population, these findings suggest a potential new treatment strategy for muscle loss to enable the ageing population to remain fit and healthy,” said study author from University of Piemonte Orientale in Italy.


Ghrelin is a hormone involved in metabolic regulation and energy balance through activation of appetite, but also plays an important role in protecting against muscle wasting.

Follow NewsGram on Facebook for more updates.

According to the researchers, both acylated (AG) and unacylated (UnAG) forms are present in the body, but UnAG does not bind to the AG receptor (GHSR-1a), so does not increase appetite.


Resistance training can help your neuromuscular system, hormones. It also can improve an older adult’s ability to convert protein to energy in as little as two weeks. Unsplash

A growing body of evidence indicates that UnAG is acting at an unidentified receptor, which also mediates some common AG and UnAG biological activities, including a strikingly protective effect against muscle wasting. “Ghrelin levels decline as we age and may be involved in the development of sarcopenia, but the role of AG versus UnAG in this process has not been investigated previously,” the team wrote.

For the current study, the research team investigated how unAG affected the age-related decline of muscle mass and function, by either deleting the ghrelin gene in mice or overexpressing unAG.

Muscle function as they aged was assessed through a wire hanging test, during which “falling” and “reaching” scores were recorded, to assess whole-body strength and endurance. Both the deletion of the ghrelin gene and the lifelong over expression of UnAG reduced age-associated decline in muscle mass and function.

Also Read: Antibody Tests Disappoint Public After Months

Despite both groups of animals displaying similar ageing tendencies in body weight and muscle mass, the mice overexpressing UnAG maintained better muscle structure, performance and metabolism, more typical of muscle in younger mice.

The study indicates that UnAG, or possibly drugs that mimic it, can preserve muscle function and reduce the risk of age-related sarcopenia, without causing weight gain and obesity.The research team now plans to identify the receptor mediating UnAG biological activities. This will help better define the molecular pathways involved in AG/UnAG actions and to design treatments that may reduce the loss of muscle mass in sarcopenia and other similar conditions. (IANS)


Popular

getty pictures

Divorce proceedings

Divorce is a hard fact in someone's life because it can affect all aspects of life like social, economic, and living status. Conditions become tougher if you have children. Recovering from divorce is also a painful process but good thing is that it is possible to get through it and place better in terms of both finances and emotions. The impact of divorce on finances can be life-lasting but taking precautions and thorough investigations of options can help a lot not only to save unnecessary costs but also some other hidden areas where you weren't aware. Following are some tips to save money during a divorce.

1.Avoid advice from everyone

Keep Reading Show less
ryunosuke kikuno/unsplash

Hosting the Olympics is an economic burden on host cities which mainly include construction delays, cost overruns, security issues, and environmental concerns.

By Saish

Gone are those days when people, sports enthusiasts, and governments lined up to host the Olympics. Hosting the Olympics, once seemed to be an immensely prideful event, but it has now transformed into an economic burden. Host cities grapple with a plethora of problems which mainly include construction delays, cost overruns, security issues, and environmental concerns.

Keep Reading Show less
ians

Tokyo Olympics 2020 Indian wrestler Ravi Kumar enter semi finals.

Indian wrestler Ravi Kumar (57kg) and Deepak Punia (86kg) enjoyed fruitful outings at the Tokyo Olympic Games as they secured semifinal berths in their respective weight categories at the Makuhari Messe on Wednesday.

On the opening day of the wrestling competition, Ravi Kumar defeated Bulgaria's Georgi Vangelov 14-4 on technical superiority to reach the last-four in the men's 57kg category, while compatriot Deepak Punia overcame China's Zushen Lin 6-3 on points to advance to the semifinals.

Ravi Kumar will take on Nurislam Sanayev of Kazakhstan in the last-four, while Punia will be up against David Morris Taylor of the USA.

Earlier, Ravi Kumar had won his opening-round bout by technical superiority against Colombia's Oscar Tigreros to secure a quarterfinal spot. Competing in the Round-of-16 bout against the Colombian wrestler, the 23-year-old Ravi Kumar, who is making his Olympic debut, showed no nerves as he dominated the bout to win by technical superiority (13-2).

Ravi Kumar landed attack after attack and went 13-2 up, winning the bout by technical superiority with minutes to spare. In wrestling, building up a 10-point lead over the opponent results in a victory by technical superiority.

India's 86kg freestyle wrestler Deepak Punia showed no signs of the niggle that had forced him to pull out of the Poland Open Ranking Series in Warsaw in June, as he defeated Nigeria's Ekerekeme Agiomor on technical superiority to secure a quarterfinal berth.

He got his Olympic campaign to a fine start as he was in control from the start of the bout and hardly ever allowed his Nigerian opponent any room to maneuver his moves, finally winning with a 12-1 on technical superiority.

Punia, who had also suffered an elbow injury just before the Games, was slow at the start but came into his own as the bout progressed, inflicting takedowns at regular intervals to earn points.

The Indian wrestler eased into a 4-1 lead at the break and extended his lead comfortably in the second period.

Punia, the silver medallist from the 2019 world wrestling championships, then set up a clash with China's Lin Zushen in the quarterfinals and defeated him 6-3.

(IANS/HP)