Sunday, September 27, 2020
Home Life Style Health & Fitness Hormone Ghrelin May Protect The Elderly Population From Muscle Loss

Hormone Ghrelin May Protect The Elderly Population From Muscle Loss

This hormone effective in muscle loss treatment: Study

Researchers have found that the hormone, ghrelin, may help protect the elderly population from muscle loss. The study, presented at e-ECE 2020 online conference on Tuesday, found that administering a particular form of ghrelin to older mice helped to restore muscle mass and strength.

“As muscle-related diseases are a serious health concern in the elderly population, these findings suggest a potential new treatment strategy for muscle loss to enable the ageing population to remain fit and healthy,” said study author from University of Piemonte Orientale in Italy.

Ghrelin is a hormone involved in metabolic regulation and energy balance through activation of appetite, but also plays an important role in protecting against muscle wasting.

Follow NewsGram on Facebook for more updates. 

According to the researchers, both acylated (AG) and unacylated (UnAG) forms are present in the body, but UnAG does not bind to the AG receptor (GHSR-1a), so does not increase appetite.

Generation Z
Resistance training can help your neuromuscular system, hormones. It also can improve an older adult’s ability to convert protein to energy in as little as two weeks. Unsplash

A growing body of evidence indicates that UnAG is acting at an unidentified receptor, which also mediates some common AG and UnAG biological activities, including a strikingly protective effect against muscle wasting. “Ghrelin levels decline as we age and may be involved in the development of sarcopenia, but the role of AG versus UnAG in this process has not been investigated previously,” the team wrote.

For the current study, the research team investigated how unAG affected the age-related decline of muscle mass and function, by either deleting the ghrelin gene in mice or overexpressing unAG.

Muscle function as they aged was assessed through a wire hanging test, during which “falling” and “reaching” scores were recorded, to assess whole-body strength and endurance. Both the deletion of the ghrelin gene and the lifelong over expression of UnAG reduced age-associated decline in muscle mass and function.

Also Read: Antibody Tests Disappoint Public After Months

Despite both groups of animals displaying similar ageing tendencies in body weight and muscle mass, the mice overexpressing UnAG maintained better muscle structure, performance and metabolism, more typical of muscle in younger mice.

The study indicates that UnAG, or possibly drugs that mimic it, can preserve muscle function and reduce the risk of age-related sarcopenia, without causing weight gain and obesity.The research team now plans to identify the receptor mediating UnAG biological activities. This will help better define the molecular pathways involved in AG/UnAG actions and to design treatments that may reduce the loss of muscle mass in sarcopenia and other similar conditions. (IANS)

STAY CONNECTED

19,138FansLike
362FollowersFollow
1,776FollowersFollow

Most Popular

The Modern Bride

Lockdown may have forced the Big Fat Indian Wedding to become a leaner affair but a bride's approach to fashion is more discerning than...

Leading change in India’s Remote Areas: Nutrition Month

When Bihar's Kurmaha village-based Lalmati Devi, a rural laborer from an impoverished background, attended sessions on health and nutrition through a self-help group she's...

76% Marathi Singles Take Their Own Decision on Marriage

Data revealed fascinating insights on Maharashtrians and their partner preferences while choosing for their marriage. Marathi Matrimony one of the leading matchmaking services for Marathis,...

Playback Singer Asha Bhosle Says- “Do Your Riyaz Daily”

When she turned 88, Asha Bhosle reinvented herself. She launched her YouTube channel, shared anecdotes about her life with audiences spanning three generations or...

Know if Natural Medicines Can Heal Coronavirus Symptoms

In the last eight months of the Coronavirus pandemic, enough cases have been made for supplementing Covid-19 treatment with natural medicine. Data emerging from...

Having Pets Linked to Reduced Psychological Stress During Lockdown

Sharing a home with a pet appeared to act as a buffer against the psychological stress during the lockdown, say researchers adding that keeping...

Checkout The Latest Trends in Travel Amid Pandemic

Online searches for accommodations over the past few months are reflecting how consumers are viewing travel in the new normal, and several unique trends...

Depression Among COVID Patients can Defeat the Mission

BY SALIL GEWALI When uncertainty and worries come calling, the body's immune system crashes. But contrastingly, one believes, COVID-19 is fought only with better immunity....

Recent Comments