Saturday January 18, 2020

Know Which Hormone in Female Protects Them From Liver Cancer!

Inhibiting testosterone production in male rodents increased their adiponectin levels and reduced tumour growth. 

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Balversa is the first approved drug in a class known as FGFR inhibitors that targets growth factor receptors involved in cell growth and division. Pixabay

Researchers have discovered that a hormone — present at higher levels in women — can keep them away from liver cancer, suggesting the disease is more common in men.

The study showed that a potential contributor to this gender disparity is adiponectin, a hormone secreted by fat cells that helps control the body’s metabolism.

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Importantly, the study suggested that adiponectin and metformin — a common antidiabetic drug — could be used as novel treatments for liver cancer. Pixabay

The hormone activates two proteins inside liver cells, known as p38 and AMPK, that block cell proliferation and impair tumour growth, said the study, published in the Journal of Experimental Medicine.

“Circulating adiponectin levels have been reported to be higher in women than in men,” said Guadalupe Sabio at the Spanish National Center for Cardiovascular Research (CNIC) in Spain.

Similar to humans, male mice are more also prone to hepatocellular carcinoma (HCC) — the most common form of liver cancer — than females, as the increased levels of adiponectin in female mice protect them from HCC, the study said.

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The study showed that a potential contributor to this gender disparity is adiponectin, a hormone secreted by fat cells that helps control the body’s metabolism. Pixabay

Inhibiting testosterone production in male rodents increased their adiponectin levels and reduced tumour growth.

Importantly, the study suggested that adiponectin and metformin — a common antidiabetic drug — could be used as novel treatments for liver cancer.

Also Read: Apple Hires Ex-Google AI Expert To Work in Its “Special Project” Team
Sabio said that adiponectin’s role in HCC is controversial and needed further investigation.

Liver cancer is the fourth leading cause of cancer-related deaths worldwide. (IANS)

 

Next Story

Women Who Have Less Sex Experience an Early Menopause: Study

Having less sex linked to earlier menopause

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Women who reported having sexual activity weekly were 28 per cent less likely to have experienced menopause than those who had sex less than once a month. Lifetime Stock

Women who have sex more often are less likely to have an early menopause, researchers say, adding that women who reported having sexual activity weekly were 28 per cent less likely to have experienced menopause than those who had sex less than once a month.

While the study, published in the journal Royal Society Open Science, didn’t look at the reason for the link, the researchers said that the physical cues of sex may signal to the body that there is a possibility of getting pregnant.

But for women who aren’t having sex frequently in midlife, an earlier menopause may make more biological sense, the study said.

“The findings of our study suggest that if a woman is not having sex, and there is no chance of pregnancy, then the body ‘chooses’ not to invest in ovulation, as it would be pointless,” said study researcher Megan Arnot from University College London in the US.

“There may be a biological energetic trade-off between investing energy into ovulation and investing elsewhere, such as keeping active by looking after grandchildren,” Arnot added.

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Women who aren’t having sex frequently in midlife, an earlier menopause may make more biological sense. Lifetime Stock

During ovulation, the woman’s immune function is impaired, making the body more susceptible to disease, the study said.

Given a pregnancy is unlikely due to a lack of sexual activity, then it would not be beneficial to allocate energy to a costly process, especially if there is the option to invest resources into existing kin.

The research is based on data collected from 2,936 women, recruited as the baseline cohort for the SWAN study in 1996/1997.

The women were asked to respond to several questions, including whether they had engaged in sex with their partner in the past six months, the frequency of sex including whether they engaged in sexual intercourse, oral sex, sexual touching or caressing in the last six months and whether they had engaged in self-stimulation in the past six months.

The most frequent pattern of sexual activity was weekly (64 per cent).

Interviews were carried out over a ten-year follow-up period, during which 1,324 (45 per cent) of the 2,936 women experienced a natural menopause at an average age of 52.

By modelling the relationship between sexual frequency and the age of natural menopause, women of any age who had sex weekly had a hazard ratio of 0.72, whereas women of any age who had sex monthly had a hazard ratio of 0.81.

This provided a likelihood whereby women of any age who had sex weekly were 28 per cent less likely to experience the menopause compared to those who had sex less than monthly.

Likewise, those who had sex monthly were 19 per cent less likely to experience menopause at any given age compared to those who had sex less than monthly.

Also Read- Here’s Everything you Need to Know About Bone Health

The study also tested whether living with a male partner affected menopause as a proxy to test whether exposure to male pheromones delayed menopause.

The researchers found no correlation, regardless of whether the male was present in the household or not. (IANS)