Monday April 22, 2019

Know Which Hormone in Female Protects Them From Liver Cancer!

Inhibiting testosterone production in male rodents increased their adiponectin levels and reduced tumour growth. 

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Balversa is the first approved drug in a class known as FGFR inhibitors that targets growth factor receptors involved in cell growth and division. Pixabay

Researchers have discovered that a hormone — present at higher levels in women — can keep them away from liver cancer, suggesting the disease is more common in men.

The study showed that a potential contributor to this gender disparity is adiponectin, a hormone secreted by fat cells that helps control the body’s metabolism.

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Importantly, the study suggested that adiponectin and metformin — a common antidiabetic drug — could be used as novel treatments for liver cancer. Pixabay

The hormone activates two proteins inside liver cells, known as p38 and AMPK, that block cell proliferation and impair tumour growth, said the study, published in the Journal of Experimental Medicine.

“Circulating adiponectin levels have been reported to be higher in women than in men,” said Guadalupe Sabio at the Spanish National Center for Cardiovascular Research (CNIC) in Spain.

Similar to humans, male mice are more also prone to hepatocellular carcinoma (HCC) — the most common form of liver cancer — than females, as the increased levels of adiponectin in female mice protect them from HCC, the study said.

liver
The study showed that a potential contributor to this gender disparity is adiponectin, a hormone secreted by fat cells that helps control the body’s metabolism. Pixabay

Inhibiting testosterone production in male rodents increased their adiponectin levels and reduced tumour growth.

Importantly, the study suggested that adiponectin and metformin — a common antidiabetic drug — could be used as novel treatments for liver cancer.

Also Read: Apple Hires Ex-Google AI Expert To Work in Its “Special Project” Team
Sabio said that adiponectin’s role in HCC is controversial and needed further investigation.

Liver cancer is the fourth leading cause of cancer-related deaths worldwide. (IANS)

 

Next Story

Violent Relationship ups Mental Disorder Risk in Women, Says New Study

However, a certain amount of unpredictability was actually healthier for women, noted researchers

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For the study, the researchers included 120 women participants, who were assessed concerning the abusive behaviour they faced and the violent environment around them. Pixabay

Women, please take note. If you are in a violent relationship you may be at an increased risk of suffering from mental disorders, suggests a new study.

The study, published in Primary Care Companion for CNS Disorders journal, indicates that the unpredictable violence not only causes physical injuries to women but also leaves the victims at a higher risk of suffering from mental disorders.

“We expect severity and frequency to be the major driver to patient outcomes, but in some cases it isn’t,” said David Katerndahl, Professor at the University of Texas Health Science Center, US.

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Representational image. Pixabay

“The nonlinearity, or unpredictability, of the violence is much more of a driver,” he added.

However, a certain amount of unpredictability was actually healthier for women, noted researchers.

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“Women who have what we call ‘optimal nonlinearity’, which means they have some nonlinearity but it’s not extreme, actually did better in the study in general,” said Katerndahl.

For the study, the researchers included 120 women participants, who were assessed concerning the abusive behaviour they faced and the violent environment around them. (IANS)