Friday April 19, 2019

How gut bacteria, broccoli can help keep colorectal cancer away

Researchers have developed a cocktail of bacteria and cruciferous vegetables that can potentially turn into a targeting system that seeks out and kills colorectal cancer cells.

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Using genetic techniques, scientists engineered the bacteria into a probiotic. Wikimedia Commons
  • Colorectal cancer is the third most common cancer worldwide.
  • The broccoli extracts can now be used to reduce the tumour size and terminate cancer.
  • Scientists have created a probiotic which will get cancer cells to kill themselves.

Researchers have developed a cocktail of bacteria and cruciferous vegetables that can potentially turn into a targeting system that seeks out and kills colorectal cancer cells.

Colorectal cancer is the third most common cancer worldwide, after lung and prostate cancer.

Although the 5-year survival rates for earlier stages of this cancer are relatively good, at later stages survival goes down and the risk of cancer recurrence goes up considerably.

Broccoli can help reduce bowel cancer.
Broccoli can help reduce bowel cancer.

Thus researchers, from the National University of Singapore, developed a mixture of engineered probiotics with a broccoli extract or water containing the dietary substance.

This mixture killed more than 95 percent of colorectal cancer cells in a dish.

Further, the probiotics-veggie combination also reduced tumour numbers by 75 percent in mice with colorectal cancer.

However, the mixture had no effect on cells from other types of cancer such as breast and stomach cancer.

These probiotics could be used as prevention and to clean up the cancer cells remaining after surgical removal of tumours, the researchers said.

“One day, colorectal cancer patients may be able to take the probiotics as a dietary supplement along with broccoli to prevent colorectal cancer or to reduce recurrence after cancer surgery,” said lead author Chun-Loong Ho from the varsity.

Broccoli when used as a dietary supplement can help reduce the risk of cancer. Image source: huffingtonpost.ca
Broccoli, when used as a dietary supplement, can help reduce the risk of cancer. Image source: huffingtonpost.ca

For the study, published in the journal Nature Biomedical Engineering, the team developed a cancer-targeting system by engineering a form of E.coli Nissle — a harmless type of bacteria found in the gut.

Then using genetic techniques, they engineered the bacteria into a probiotic that attached to the surface of colorectal cancer cells and secreted an enzyme to convert a substance found in broccoli, into a potent anticancer agent.

The idea was for the cancer cells in the vicinity to take up this anticancer agent and be killed. IANS

Next Story

Consumption of Allium Vegetables Like Onion, Garlic May Lower Risk of Colorectal Cancer

For the study, 833 patients of colorectal cancer were matched to 833 healthy controls by age, sex and residence area

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Consuming of allium vegetables including garlic, onion and leek, is associated with a reduced risk of colorectal cancer, researchers say.

Colorectal cancer is the cancer of the colon or rectum, located at the digestive tract’s lower end.

The study, published in the Asia Pacific Journal of Clinical Oncology, showed that the odds of having colorectal cancer was 79 per cent lower in adults who consumed high amounts of allium vegetable compared with those who consumed them in low amounts.

“It is worth noting that in our research, there seems to be a trend: the greater the amount of allium vegetables, the better the protection,” said researcher Zhi Li from the First Hospital of China Medical University.

Cancer
Cancer Ribbon. Pixabay

“In general, the present findings shed light on the primary prevention of colorectal cancer through lifestyle intervention, which deserves further in-depth explorations.”

For the study, 833 patients of colorectal cancer were matched to 833 healthy controls by age, sex and residence area.

Also Read- Common Heartburn Drug Linked to Kidney Disease Risk, Says Study

Importantly, according to World Health Organization, colorectal cancer is one of the most common cancers around the world along with male preponderance with 1.80 million cases and 862,000 deaths in 2018.

In addition, the incidence is on the rise in India. (IANS)