Tuesday, November 24, 2020
Home Life Style Health & Fitness Immune Cells Become Active and Repair Brain While Sleep: Study

Immune Cells Become Active and Repair Brain While Sleep: Study

For the findings, researchers conducted the study on mice

Researchers have found that immune cells called microglia, which play an important role in reorganising the connections between nerve cells, fighting infections, and repairing damage, are also primarily active while we sleep.

Microglia serve as the brain’s first responders, patrolling the brain and spinal cord and springing into action to stamp out infections or gobble up debris from dead cell tissue.

“This research shows that the signals in our brain that modulate the sleep and awake state also act as a switch that turns the immune system off and on,” said study lead author Ania Majewska, Professor at University of Rochester in the US.

In previous studies, Majewska’s lab has shown how microglia interact with synapses, the juncture where the axons of one neuron connects and communicates with its neighbours.

The microglia help maintain the health and function of the synapses and prune connections between nerve cells when they are no longer necessary for brain function.

For the findings, researchers conducted the study on mice.

The current study points to the role of norepinephrine, a neurotransmitter that signals arousal and stress in the central nervous system.

This chemical is present in low levels in the brain while we sleep, but when production ramps up it arouses our nerve cells, causing us to wake up and become alert.

The study showed that norepinephrine also acts on a specific receptor, the beta2 adrenergic receptor, which is expressed at high levels in microglia.

When this chemical is present in the brain, the microglia slip into a sort of hibernation.

Sleep
Researchers have found that immune cells called microglia, which play an important role in reorganising the connections between nerve cells, fighting infections, and repairing damage, are also primarily active while we Sleep and affects Brain. Pixabay

The study, which employed an advanced imaging technology that allows researchers to observe activity in the living brain, showed that when mice were exposed to high levels of norepinephrine, the microglia became inactive and were unable to respond to local injuries and pulled back from their role in rewiring brain networks.

“This work suggests that the enhanced remodeling of neural circuits and repair of lesions during sleep may be mediated in part by the ability of microglia to dynamically interact with the brain,” said study first author Rianne Stowell.

ALSO READ: Scientists Link ‘Brain Fog’ to Body Illness

“Altogether, this research also shows that microglia are exquisitely sensitive to signals that modulate brain function and that microglial dynamics and functions are modulated by the behavioural state of the animal,” Stowell said.

The study was published in the journal Nature Neuroscience. (IANS)

STAY CONNECTED

19,120FansLike
362FollowersFollow
1,783FollowersFollow

Most Popular

MP Govt To Produce Clean Fuel From Stubble Burnt

The Madhya Pradesh government has proposed a plan to set up an industrial unit producing fuel from stubble burnt by the farmers in the...

Felling of 315 Trees When Air Quality is Worse in Delhi

The Delhi High Court on Monday sought a response from the AAP government and others over a petition against an order for felling of...

Cyber Frauds May Increase in India in 2021: Kaspersky

With more users getting connected to the Internet and entering the digital payments ecosystem, cyber fraud incidents may go up in 2021, a researcher...

UP Marks Record in Production And Sales of Sanitizers

The Yogi Adityanath government in Uttar Pradesh has used the 'opportunity in adversity' concept to create a record of sorts in the production and...

Greater Risks of STI in People Above 45

Researchers have found that people above 45s are at a higher risk of contracting sexually transmitted infections (STIs) than ever before because of society's...

SC Happy About Permanent Commission of Women Army Officers

The Supreme Court on Monday expressed happiness after learning that the Centre has implemented its verdict to grant permanent commission to women officers in...

IT Spending of India To Rise By 6% in 2021: Gartner

IT spending in India is set to reach $81.9 billion next year, a growth of six percent from 2020, according to a forecast by...

Economic Reforms Agenda To Continue: Nirmala Sitharaman

Union Finance Minister Nirmala Sitharaman on Monday said that the government will continue its reform agenda and take up more measures in days ahead. In...

Recent Comments