New Delhi, March 25: Researchers, including one of Indian-origin, have developed novel peptide-like analogs or peptoids that have the similar antimicrobial properties as peptides but more robust.
The discovery, paves the way for creation of new generation antibiotics that can defeat the so called multi-drug resistant bacteria “superbugs”.
Like proteins, peptides are chains of amino acids that participate in the metabolic system of living organisms and the immune system.
They are the first line of defence against a broad range of pathogens, and are released by the body in the earliest stage of infection.
These peptides are attractive antimicrobials. However, they degrade in the body and have short half-life.
Rinki Kapoor along with her PhD advisor and professor Annelise Barron of Stanford University studied novel mimics of antimicrobial peptides or peptoids for their antibacterial activity against multi-drug resistant bacteria, also known as superbugs.
In one of their studies, they showed that peptoids kill resistant Pseudomonas aeruginosa, one of the leading bug causing hospital associated infections.
The group synthesised seven different peptoids and compared their activity with three different antibiotics.
In a separate study, Kapoor and Barron also revealed that peptoids kill resistant Mycobacteria, bacteria responsible for causing Tuberculosis, a leading cause of death worldwide. In this study, published in the journal of antimicrobial agents and chemotherapy (AAC), they evaluated the efficacy of six different peptoids against Mycobacteria.
“These molecules are currently under research and development and merit further studies to investigate their potential as new class of drugs for treating resistant bacterial infections,” Kapoor told reporters. (IANS)
Brooklyn judge on Thursday ruled against a group of parents who challenged New York City’s recently imposed mandatory measles vaccination order, rejecting their arguments that the city’s public health authority exceeded its authority.
In a six-page decision rendered hours after a hearing on the matter, Judge Lawrence Knipel denied the parents’ petition seeking to lift the vaccination order, imposed last week to stem the worst measles outbreak to hit the city since 1991.
The judge sided with municipal health officials who defended the order as a rare but necessary step to contain a surge in the highly contagious disease that has infected at least 329 people so far, most of them children from Orthodox Jewish communities in the borough of Brooklyn.
Another 222 cases have been diagnosed elsewhere in New York state, mostly in a predominantly ultra-Orthodox Jewish neighborhood of Rockland County, northwest of Manhattan.
The New York outbreaks are part of a larger resurgence of measles across the country, with at least 555 cases confirmed in 20 states, according to the U.S. Centers for Disease Control and Prevention.
Health experts say the virus, which can cause severe complications and even death, has spread mostly among school-age children whose parents declined to get them vaccinated. Most profess philosophical or religious reasons, or cite concerns — debunked by medical science — that the three-way measles-mumps-rubella (MMR) vaccine may cause autism.
The judge rejected the parents’ contention that the vaccination order was excessive or coercive, noting it does not call for forcibly administering the vaccine to those who refuse it.
He also dismissed assertions in the petition disputing the “clear and present danger” of the outbreak. “Vaccination is known to extinguish the fire of contagion,” the judge said.
The vaccination order, which was extended this week, requires residents of certain affected Brooklyn neighborhoods to obtain the MMR vaccine unless they can otherwise demonstrate immunity to measles, or face a fine.
The court challenge was brought in Brooklyn’s Supreme Court by five people identified only as parents living in the affected neighborhoods. Their identities were kept confidential to protect their children’s’ privacy, their lawyers said.
In court on Thursday, they told Knipel the city had overstepped its authority and that quarantining the infected would be a preferable approach.
Robert Krakow, an attorney for the parents, estimated that just 0.0006 percent of the population of Brooklyn and Queens had measles. “That’s not an epidemic,” he said. “It’s not Ebola. It’s not smallpox.”
The health department’s lawyers argued that quarantining was ineffective because people carrying the virus can be contagious before symptoms appear.
The judge cited 39 cases diagnosed in Michigan that have been traced to an individual traveling from the Williamsburg community at the epicenter of Brooklyn’s outbreak.