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Infertile Women Tend to Develop High risk of Cancer

For the study, the team analysed data from 64,345 infertile women who were followed for nearly four years

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infertile, cancer
Infertile women had an overall 18 per cent higher risk of developing cancer compared to women who were not infertile. Pixabay

Infertility is associated with a higher risk of developing cancer in women of childbearing age, say researchers including one of Indian-origin.

The findings, published in the journal Human Reproduction, showed that infertile women had an overall 18 per cent higher risk of developing cancer compared to women who were not infertile.

However, the absolute risk is very low at just two per cent compared to 1.7 per cent among women who are not infertile, found researchers at Stanford University in the US.

“We do not know the causes of the increase in cancer that we found in this study, whether it might be the infertility itself, the causes of the infertility, or the infertility treatment,” said lead author Gayathree Murugappan.

cancer, infertile
They also found a slightly higher risk of cancers of the lung, thyroid, liver and gallbladder and leukaemia among the infertile women. Pixabay

“We can only show there is an association between them,” she added.

For the study, the team analysed data from 64,345 infertile women who were followed for nearly four years.

Although breast cancer was the most common in both fertile and infertile women, the team found a slightly higher risk of hormone-driven cancers of the ovary and uterus among the infertile women.

They also found a slightly higher risk of cancers of the lung, thyroid, liver and gallbladder and leukaemia among the infertile women.

“While several of these associations were significant, it is important to note that the absolute increases in risk were modest,” said Murugappan.

infertile, cancer
For the study, the team analysed data from 64,345 infertile women who were followed for nearly four years. Pixabay

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“The low overall incidence of cancer among these women means that one in 49 infertile women would develop cancer during the follow-up period compared to one in 59 women who were not infertile,” said Michael Eisenberg, Associate Professor at the varsity.

Further research needs to be carried out to determine what factors may be influencing the long-term risk of cancer for infertile women, Eisenberg noted. (IANS)

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Researchers Discover Balance of Two Enzymes That May Help Treat Pancreatic Cancer

While still in the earliest stages, Newton hoped this information might one day aid pancreatic diagnostics and treatment

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Cancer
Cancer Ribbon. Pixabay

A new research has set the stage for clinicians to potentially use levels of a pancreatic cancer patient’s PHLPP1 and PKC enzymes as a prognostic and for researchers to develop new therapeutic drugs that change the balance of the two enzymes as a means to treat the disease.

The study, published on Wednesday in Molecular Cell, was led by Alexandra Newton, professor in the Department of Pharmacology at the University of California, San Diego, School of Medicine, and Timothy Baffi, a graduate student in her lab, Xinhua news agency reported.

The new study built on the team’s work in 2015 that found the enzyme PKC, which was believed in previous studies to promote tumour growth, actually suppressed it.

The latest study took the investigation a step further by uncovering how cells regulate PKC activity and discovered that any time an over-active PKC is inadvertently produced, the PHLPP1 “proofreader” tags it for destruction.

Cancer patient
Cancer patient.

“That means the amount of PHLPP1 in your cells determines your amount of PKC,” Newton said. “And it turns out those enzyme levels are especially important in pancreatic cancer.”

The team observed 105 pancreatic cancer tumours to analyze the enzyme levels in each one. About 50 per cent of patients with low PHLPP1/high PKC lived longer than five-and-a-half years.

Also Read- A Brain Circuit Can Help Reverse Craving for Liquor, Says Study

While still in the earliest stages, Newton hoped this information might one day aid pancreatic diagnostics and treatment.

Pancreatic cancer is caused by the abnormal and uncontrolled growth of cells in the pancreas, a large gland in the digestive system. It typically doesn’t show symptoms in the early stages. Sufferers tend to develop signs, such as back pain and jaundice, when it has spread to other organs. (IANS)