Sunday April 5, 2020

Iron Build-up in Lungs Can Worsen Asthma Symptoms: Study

High iron in lung linked to increased asthma severity

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Lungs asthma
Iron build-up in the lungs is associated with worse asthma symptoms and lower lung function. Pixabay

Iron build-up in the lung cells and tissues is associated with worse asthma symptoms and lower lung function, say health and lifestyle researchers.

The study, published in the European Respiratory Journal, included data from asthma patient samples and mouse models, and showed a relationship between iron build-up in the lung cells and tissues and the severity of asthma.

Experimental models also showed that iron build-up in the lungs triggers immune system responses that are typical in asthma and lead to worsening of the disease.

This includes effects like increased mucus secretion and scarring of the lungs, which result in narrowing of the airways and making breathing difficult.

Lungs asthma
In a separate genetic model, the researchers triggered iron overloading in the lung cells of mice that were fed a normal iron diet, to assess the effects on the lungs. Pixabay

“We showed that lung function was lowest among patients with the highest levels of iron build-up in their airway cells and tissues,” said study lead author Jay Horvat, Associate Professor at the University of Newcastle in Australia.

“As lower iron levels outside of cells and higher iron levels within cells were both associated with worse lung function, we think that the immune system’s role in ‘hiding’ iron minerals within the lung cells may be contributing to asthma severity,” Horvat added.

For the findings, the researchers used a combination of asthma patient samples and experimental models to investigate irregular iron absorption into lung cells and to assess how lung cell iron levels affect disease severity.

First, the researchers assessed airway cell iron levels in 11 severe and 12 mild-to-moderate asthma patients and compared their iron levels with 12 healthy people who did not have asthma.

Asthma severity was determined by how much air a person could breathe out in one second and based on the frequency of experiencing asthma symptoms.

The researchers collected airway cell samples from participants using biopsy.

They also conducted multiple tests to asses iron levels in the airway cell samples and found that iron levels outside of the lung cells were lower in asthma patients compared with healthy people; iron levels were also significantly lower in severe asthmatics compared with mild-to-moderate asthmatics.

Lungs asthma
Experimental models also showed that iron build-up in the lungs triggers immune system responses that are typical in asthma and lead to worsening of the disease. Pixabay

In contrast, iron levels within the lung cells were markedly higher in the bronchoscope ‘wash’ samples of mild-to-moderate and severe asthmatics compared with healthy people.

The difference in lung cell iron levels between severe asthmatics compared with mild-to-moderate asthmatics was not significant, but the analyses showed that having high levels of iron in the lung cells and less iron outside of cells was associated with more severe airflow obstruction.

Taken together, the results show that lower iron levels outside of cells and higher iron levels within cells were both associated with lower lung function and worse asthma.

Next, the researchers carried out lab tests using two different mouse models to investigate the effects of increasing lung cell iron levels on asthma severity.

In one of the experimental models conducted over an eight-week period, one group of mice was exposed to iron overload through diet and another group were fed a normal low-iron diet.

After eight weeks, liver and lung tissues were collected from the mice for further analysis and airway inflammation was measured.

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In a separate genetic model, the researchers triggered iron overloading in the lung cells of mice that were fed a normal iron diet, to assess the effects on the lungs.

The analyses showed that increasing the lung cell iron levels caused inflammatory cell responses such as increased mucus secretion and scarring in the airways, which the researchers say leads to worsening of asthma. (IANS)

Next Story

Here Are Some Health Benefits of Going Vegan

Veganism is a lifestyle that tries to bar, as far as possible and practicable, all kinds of exploitation of, and cruelty to, animals for food, or any other purpose

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Vegan
Veganism is a lifestyle that tries to bar, as far as possible and practicable, all kinds of exploitation of, and cruelty to, animals for food, or any other purpose. Pixabay

Vegan people follow a plant-based diet and do not eat animal products including dairy, meat, eggs, honey, and gelatin. But, veganism goes beyond the diet.

Veganism is a lifestyle that tries to bar, as far as possible and practicable, all kinds of exploitation of, and cruelty to, animals for food, or any other purpose.

Nutritionist and founder of Diet Podium, Shikha Mahajan, shares these five benefits going vegan has on your health.

Reduced risk of cancer

In 2015, the Worle Health Organisation named red meat a Group 2 Carcinogen, which means it probably causes cancer in humans. WHO placed processed meat in the Group 1 category, which means it is carcinogenic to humans.

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Even small amounts of meat can increase the risk of cancer. A study from Oxford University study also found that eating just 3 rashers of bacon a day can increase cancer risk by 20 percent.

Reduced risk Of diabetes

More and more research is concluding that a plant-based diet can reduce the risk of developing diabetes or even reverse the disease completely.

A study, that included more than 2,000 adults, found those people who increased the number of fruit, vegetables, and nuts in their diet over the duration of 20 years reduced their risk of developing type 2 diabetes by 60 percent more than those who did not.

Enhanced mood

A study done by the Physicians Committee for Responsible Medicine (PCRM) shows a study on its website that looks at the eating patterns and moods of 3,486 people over a five-year period. The study showed that participants who consumed whole, plant foods reported fewer signs of depression.

Vegan
Vegan people follow a plant-based diet and do not eat animal products including dairy, meat, eggs, honey, and gelatin. But, veganism goes beyond the diet. Pixabay

A different study showed that vegetarians usually experience more positive moods than meat-eaters.

Healthy skin

A plant-based diet might boost your beauty regime by assisting your skin in staying healthy. An increasing number of studies are associating dairy to skin problems such as acne. Dairy products have growth hormones and are also sometimes infused with artificial hormones, which can disrupt the human body’s hormone system.

ALSO READ: Find Here if Water Treatment Methods Can Kill Coronavirus Or Not

Fewer cardiovascular diseases

Meat generally contains a high quantity of saturated and trans-fats which can increase blood cholesterol. Cholesterol can create fatty deposits in the blood vessels that increase the risk of stroke, peripheral artery disease, and heart disease. Plant-based foods, by nature, have no dietary cholesterol. A diet high in fat and cholesterol can also lead to high blood pressure. (IANS)