An Israeli study said on Sunday that fungal infections could be cured using bacteria found in the soil.
The researchers tried using bacillus subtilis bacteria, which naturally secrete substances that inhibit candida growth, according to the study published by the Israel Institute of Technology “Technion,” Xinhua reported.
The researchers developed a new model for drug therapy, which is a tiny “factory” where the bacteria inside it begin to produce the active substance.
The prevalence of fungal infections is on the rise due to the aging of the population, global warming and the increasing use of antibiotics.
The effectiveness of pills currently available for fungal infections is low due to side effects such as headaches and rash, and in some cases, life-threatening toxicity in the liver and kidneys.
Fasting may not be just a religious or political practice. It may actually protect you against age-related diseases and improve your overall health, researchers say.
The study, led by a team from the University of California-Irvine (UCI), found that fasting affects circadian clocks in the liver and skeletal muscle, causing them to rewire their metabolism, which can ultimately lead to improved health and protection against age-related diseases.
The circadian clock operates within the body and its organs as intrinsic time-keeping machinery to preserve homeostasis in response to the changing environment.
And, while food is known to influence clocks in peripheral tissues, it was unclear until now how the lack of food influences clock function and ultimately affects the body.
“We discovered fasting influences the circadian clock and fasting-driven cellular responses, which together work to achieve fasting-specific temporal gene regulation,” said lead author Paolo Sassone-Corsi, Professor of Biological Chemistry at UCI.
“Skeletal muscle, for example, appears to be twice as responsive to fasting as the liver,” Sassone-Corsi added.
The research, detailed in the Cell Reports journal, was conducted using mice, which were subjected to 24-hour periods of fasting.
While fasting, the mice exhibited a reduction in oxygen consumption (VO2), respiratory exchange ratio (RER), and energy expenditure, all of which were completely abolished by refeeding, which parallels results observed in humans.
“The reorganisation of gene regulation by fasting could prime the genome to a more permissive state to anticipate upcoming food intake and thereby drive a new rhythmic cycle of gene expression. In other words, fasting is able to essentially reprogram a variety of cellular responses,” Sassone-Corsi said.