Tuesday January 28, 2020

Kids in LMICs Receive Excessive Amount of Antibiotic Prescriptions

Kids in low income countries prescribed excess antibiotics

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Antibiotic Prescriptions
Children who receive excessive antibiotic prescriptions may lose the ability to fight pathogens. Pixabay

Kids in low and middle-income countries (LMICs) are receiving an excessive amount of antibiotic prescriptions that could harm the children’s ability to fight pathogens as well as increase antibiotic resistance worldwide, warns a new study.

Children in these countries received 25 antibiotic prescriptions through age five – a “remarkable” estimate, given that two antibiotic prescriptions per year is considered excessive in many high-income settings, said the study published in the journal The Lancet Infectious Diseases.

“We knew children in LMICs are sick more often, and we knew antibiotic prescription rates are high in many countries. What we did not know was how these elements translate into actual antibiotic exposure – and the results are rather alarming,” said lead author of the study Gunther Fink from Swiss Tropical and Public Health Institute (Swiss TPH), Basel, Switzerland.

Antimicrobial resistance is one of today’s biggest threats to global health and development, according to the World Health Organization.

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Children in LMICs received 25 antibiotic prescriptions through age. Pixabay

One factor contributing to this global health threat is the excessive use of antibiotics worldwide.

The research team from Swiss TPH and Harvard T.H. Chan School of Public Health in the US analysed data from 2007-2017 from health facilities and household surveys from eight countries: Haiti, Kenya, Malawi, Namibia, Nepal, Senegal, Tanzania, and Uganda.

Results showed that antibiotics were administered in 81 per cent of cases for children with a respiratory illness, in 50 per cent for children with diarrhoea, and in 28 per cent for children with malaria.

The researchers found that the number of antibiotic prescriptions in early childhood varied from country to country.

While a child in Senegal received approximately one antibiotic prescription per year in the first five years of life, a child in Uganda was prescribed up to 12.

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In comparison, a prior study showed that children under five in Europe receive less than one antibiotic prescription per year on average.

“This number is still high given that the vast majority of infections in this age group are of viral origin,” said study co-author Valerie D’Acremont from Swiss TPH. (IANS)

Next Story

Children of Mothers With Diabetes Are Likely To Suffer From Heart Diseases, Says Study

The researchers also found higher rates for specific types of CVD children of mothers with diabetes

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Diabetes
Diabetes was categorised as pregestational (before pregnancy) or gestational (during pregnancy) and women with diabetic complications were identified in the Study. Pixabay

Children of mothers with diabetes have increased rates of early onset cardiovascular disease or CVD (conditions affecting the heart or blood vessels) from childhood up to the age of 40, the researchers have warned.

The increased rates were more pronounced among children of mothers with a history of CVD or diabetic complications, said the study published in the journal The BMJ.

“Our study provides evidence that children of mothers with diabetes, especially those with a history of CVD or with diabetic complications, had increased rates of early onset CVD throughout the early decades of life,” said study researchers from Aarhus University in Denmark.

If this association is shown to be causal, preventing, screening, and treating diabetes in women of childbearing age could be important not only for improving the health of the women but also for reducing long term risks of CVD in their offspring, the researchers added

The number of women diagnosed with diabetes before or during pregnancy has increased globally, and children of these women are more likely to have risk factors for future CVD, such as high blood pressure and high blood sugar levels. It is unclear, however, whether or to what extent exposure to diabetes in the womb increases the risk of developing CVD in offspring over a lifetime.

So an international team of researchers set out to evaluate associations between diabetes diagnosed before or during pregnancy and early onset CVD in children during their first four decades of life. They base their findings on national registry data for over 2.4 million children born without congenital heart disease in Denmark from 1977 to 2016.

Diabetes was categorised as pregestational (before pregnancy) or gestational (during pregnancy) and women with diabetic complications were identified.

Diabetes
Children of mothers with diabetes have increased rates of early onset cardiovascular disease or CVD (conditions affecting the heart or blood vessels) from childhood up to the age of 40, the researchers have warned. Pixabay

Other potentially influential factors, such as mother’s age, education, lifestyle and medical history were also taken into account. During up to 40 years of follow-up, children of mothers with diabetes had a 29 per cent increased overall rate of early onset CVD compared with children of mothers who did not have diabetes (cumulative risks: 17.8 per cent vs 13.1 per cent ).

The researchers also found higher rates for specific types of CVD children of mothers with diabetes, particularly heart failure (45 per cent), hypertensive disease (78 per cent), deep vein thrombosis (82 per cent), and pulmonary embolism (91 per cent).

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Increased rates were seen in each age group in childhood (before 20 years of age) and early adulthood (from 20 to 40 years of age), regardless of the type of diabetes they were exposed to (pregestational or gestational) and rates were similar for both type 1 and type 2 diabetes, the study said. (IANS)