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Breast cancer in men is rarely seen. It shares many similarities with cancer of the breast in women but there are some important differences too.
Male breast cancer represents between 0.5 and 1 per cent of all breast cancers diagnosed each year. Higher rates of male cancer in central and eastern Africa may be related to higher liver infectious diseases that lead to hypoestrogenism.
Dr Kumardeep Dutta Choudhury, Senior Consultant & Head of Department, Dept of Medical Oncology (IOSPL), Fortis Hospital, Noida, shares the facts you need to know about it.
Risk factors associated with breast cancer in men:
Genetics and family history
Family history of cancer in a first-degree relative is associated with an increased risk of breast cancer among men. Approximately 15 to 20 per cent of men with breast cancer have a family history of the disease compared with only 7 per cent of the general male population.
The risk is higher with inherited BRCA2 rather than BRCA1 mutations. Other genes which have been associated with an increased risk of breast cancer in men are PTEN tumor suppressor gene (Cowden syndrome), tumor protein p53 (TP53; Li-Fraumeni syndrome), partner and localizer of BRCA2 (PALB2), and mismatch repair genes (Lynch syndrome).
Alterations of the estrogen to androgen ratio
Excessive estrogen stimulation may be due to hormonal therapies (e.g., estrogen-containing compounds or testosterone), hepatic dysfunction, obesity, marijuana use, thyroid disease, or an inherited condition, such as Klinefelter syndrome may increase risk of male breast cancer.
Primary testicular conditions
Testicular conditions may increase risk of breast cancer in men include orchitis, undescended testes (cryptorchidism), and testicular injury.
Male breast cancer has been diagnosed at a more advanced stage than female breast cancer, due to a lack of awareness. They generally present with a painless, firm mass that is usually subareolar, with nipple involvement in 40 to 50 percent of cases. The left breast is involved slightly more often than the right, and less than 1 percent of cases are bilateral. There may be associated skin changes, including nipple retraction, ulceration, or fixation of the mass to the skin or underlying tissues. Axillary nodes are typically palpable in advanced cases.
Most histologic subtypes of that cancer seen in women are also present in men, men with breast cancer are rarely diagnosed with lobular carcinomas is due to lack of acini and lobules in the normal male breast, although these can be induced in the context of estrogenic stimulation.
Approach to treatment in men is same as that for women. However, role of breast conserving surgery is limited because of small volume of breast tissue. In hormone receptor-positive disease, we give adjuvant tamoxifen rather than an aromatase inhibitor (AI), because of insufficient evidence to support AI monotherapy for men. If there are contraindications to tamoxifen (e.g., hypercoagulable state), an AI with GnRHa may be administered. AIs do not reduce testicular production of estrogens, that’s why GnRHa is administered concurrently with AI. They are treated with mastectomy, radiotherapy, chemotherapy and hormone therapy.
Limited data suggest these patients are at an increased risk of a contralateral breast cancer, but absolute risk is low. They are also at risk for secondary malignancies and 12.5 percent may develop a second primary cancer. The most common types were gastrointestinal, pancreas, non-melanoma skin, and prostate cancer.
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Ten-year disease-specific survival rates for histologically negative nodes – 77 and 84 per cent, one to three positive nodes – 50 and 44 per cent and four or more histologically positive nodes – 24 and 14 per cent. (IANS)
One of Indi's leading luxurious Ayurveda skincare brands, Forest Essentials, announces its international foray with the London based Lookfantastic.com, Euroe's premium online beauty retailer. The partnership enables the brand to take significant strides towards its expansion globally starting with the launch in the United Kingdom. "Our focus and USP at Forest Essentials has always been at delivering high quality Ayurvedic products in a sustainable way, with a global appeal.
We firmly believe that the time is right for Forest Essentials to expand to the UK, as our first international footprint with Lookfantastic,' Europe's premium online beauty retailer. "The UK audience is well aware of Ayurveda and we are certain that the demand for our Made in India luxurious Ayurveda products, is going to continue to grow multifold, as consumers are today looking for moments of self-care, to feel better in this stressful period and we are well positioned to support this type of feel-good indulgence that consumers are seeking today," says Samrath Bedi, Executive Director, Forest Essentials. The brand's iconic product ranges, across skincare, body care and haircare will be available for purchase in the UK, including the Soundarya collection, crafted with 24k gold.
The brand's iconic product ranges, across skincare, body care and haircare will be available for purchase in the UK, including the Soundarya collection, crafted with 24k gold. | Wikimedia Commons
The brand's iconic product ranges, across skincare, body care and haircare will be available for purchase in the UK, including the Soundarya collection, crafted with 24k gold. Additional collections offered include the Men's Collection, Madurai Jasmine and Mogra, Green Tea and Oudh, and Nargis, Indian Rose Ab'olute. The brand's vast gifting options are also available via the e-retailer. A portfolio of over 660 premium brands onsite and revenue share grown 40 percent year on year in the last 4 year makes,
Lookfantastic is one of the most successful beauty websites globally. Unrivalled technology, a team of world-class experts, over 30 localized sites in as many languages enables the website to attract millions of visits per month with nearly 71 percent of them being international making it a natural choice as a retail overseas partner for Forest Essentials. Commenting on the announcement, Bedi added, "Ayurveda has gained acceptance globally and there is an increased need to explore authentic products that are not only luxurious but also high on efficacy. Forest Essentials has been a pioneer in every sense and we're confident that our foray into the UK will enable us to represent India and products Made in India successfully in the international market." (IANS/MBI)
Keywords: Ayurveda, Skincare, Forest, Herbal, Body care, Hair care, Beauty Products
Khadi is no longer a dull, drab fabric meant only for politicians' wardrobes. A fashion show organised by the Khadi Gramodyog Board as part of the Azadi Ka Amrit Mahotsav to mark the 75th year of India's Independence showcased the use of Khadi in traditional, as well as, contemporary and festive wear. From lehengas in resplendent Khadi silk to western clothes and casual wear, the models on Thursday night displayed new facts of the fabric.
Several well-known Indian designers including Ritu Beri, Farah Ansari, Rina Dhaka, Asma Husain, Aditi Rastogi and Himmat Singh showcased their designs. Gaurav Gaur directed the fashion show with clothes like lehengas, kurtis, kurta pajamas and partywear.
Lucknow's chikankari and silk artisans also participated in the event. A wedding collection in Khadi was the highlight of the show. "The show was based on the concept 'Khadi for nation, Khadi for fashion' and the fabric for all costumes was provided by Khadi Gramodyog Board," said a spokesman. (IANS/ MBI)
Keywords: lucknow, clothes, lehengas, fashion, fabric
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Intel saw its stock tumbling by more than 8 percent after the chipmaker said the industry-wide component shortage affected its PC chip business during the third quarter (Q3). Intel CEO Pat Gelsinger told CNBC late on Thursday that he didn't expect the semiconductor shortage to end until 2023. "We're in the worst of it now, every quarter, next year we'll get incrementally better, but they're not going to have supply-demand balance until 2023," Gelsinger was quoted as saying.
The company delivered its Q3 results with revenue up 5 percent (year-over-year) driven by strong demand in its DCG and IoTG businesses, despite the highly constrained industry-wide supply environment. "Q3 revenue was $18.1 billion slightly below our guide due to shipping and supply constraints that impacted our businesses," George S. Davis, Chief Financial Officer, said in a statement. He also announced plans to retire from Intel in May 2022. In the third quarter, the company generated $9.9 billion in cash from operations and paid dividends of $1.4 billion.
| Photo by Slejven Djurakovic on Unsplash
According to the company, the demand remains strong in its PC business with particular strength in commercial, desktop, and higher-end consumer notebooks. In an earnings call, Gelsinger said that the digitization of everything accelerated by the four superpowers of AI, pervasive connectivity, cloud to edge infrastructure, and ubiquitous compute are driving the sustained need for more semiconductors. "The market is expected to double to $1 trillion by 2030. In that timeframe, the market for leading-edge nodes will rise to be over 50 percent of the total, while the market for leading-edge foundry services will grow at twice the rate of the semi-industry overall," he envisioned.
PC demand remains very strong, and "We believe the 2021 TAM (total addressable market) will grow double digits even as ecosystem shortages constrain our customer's ability to ship finished systems," Gelsinger added. "Customers continue to choose Intel for their datacenter needs and our third-gen scalable Xeon processor Ice Lake has shipped over 1 million units since launching in April, and we expect to ship over 1 million units again in Q4 alone," he informed. (IANS/MBI)
Keywords: Intel, Chip, processor, Desktop, AI, Semiconductor, PC, Processor