Sunday September 22, 2019

Lead Intake Promotes Accumulation of Fat in Liver which Can Cause Obesity

And the actual number could be higher as the condition often goes undiagnosed

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Epidemiological studies have shown that this affects nine to 32 per cent of the Indian population. Pixabay

Researchers at the Indian Institute of Technology, Mandi have shown how lead intake promotes accumulation of fat in the liver which can cause obesity.

The scientists have unravelled the mechanism by which lead salt can promote fat accumulation in the liver.

Epidemiological studies have shown that this affects nine to 32 per cent of the Indian population. And the actual number could be higher as the condition often goes undiagnosed.

Non-alcoholic fatty liver disease (NAFLD) is a dangerous epidemic of this generation and is a rapidly growing health problem intimately related to the metabolic group of diseases such as obesity and diabetes, among others.

Lead, Fat, Obesity
Researchers at the Indian Institute of Technology, Mandi have shown how lead intake promotes accumulation of fat in the liver which can cause obesity. Pixabay

It is a conditioAlson wherein there is excessive fat accumulation in the liver.

While obesity has been known to be the leading cause for NAFLD, recent observations have shown that even thin people can be metabolically ‘obese’ and have NAFLD.

Their research work was performed in collaboration with researchers from the Council of Scientific and Industrial Research (CSIR), Indian Institute of Toxicology Research in Lucknow and School of Chemical and Life Sciences in Jamia Hamdard in New Delhi.

This research work has recently been published in a reputed peer-reviewed journal “FEBS Letters”.

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Prosenjit Mondal, Assistant Professor, School of Basic Sciences, IIT Mandi, who has uncovered the pathway by which lead promotes NAFLD, said: “While the connection between lead and fatty liver disease has been known for a while, the actual mechanism by which lead worsens this condition has hitherto remained unknown.”

NAFLD and most metabolic group of diseases are often caused by the poor regulation of De novo lipogenesis, a complex process in which carbohydrates circulating in the blood are converted into fat.

The poor regulation of De novo lipogenesis leads to abnormal production of fat, which settles in the liver and other internal organs as visceral fat.

It has been found that the metal lead, which is a serious environmental toxin, can lead to poor regulation of fat formation and deposition in the liver.

Lead, Fat, Obesity
The scientists have unravelled the mechanism by which lead salt can promote fat accumulation in the liver. Pixabay

Lead toxicity is a serious concern in India and the use of lead containing paints, pesticides, packaging and even beer contributes towards high exposure of Indians to this toxic metal and its salts.

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Lead salts absorbed by the human body is stored in soft tissues, and autopsy studies have shown that the liver hoards almost 33 per cent of the total lead cruising in the body. (IANS)

Next Story

Heart Disease, Stroke-related Deaths on Rise Due to Obesity: Study

The researchers observed that obesity is the main risk factors for cardiovascular disease mortality — others include smoking, high blood pressure, high cholesterol and diabetes

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India with 14.4 million had the second highest number of obese children in 2015. Pixabay

Heart disease and stroke mortality rates have almost stopped declining in many high-income countries and are even increasing in some countries, reveals a new study.

For the study, published in the International Journal of Epidemiology, researchers from the University of Melbourne analysed trends in cardiovascular disease mortality, which consists of mainly heart disease and stroke — in 23 high-income countries since the year 2000.

The study found that cardiovascular disease mortality rates for people aged 35 to 74 years are now barely declining, or are increasing, in 12 of the 23 countries.

Cardiovascular disease mortality rates have increased in the most recent years in US and Canadian females, while in Australia, the UK and New Zealand annual declines in deaths from cardiovascular diseases are now 20 to 50 per cent.

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Two women converse in New York, June 26, 2012. The nation’s obesity epidemic continues to grow, led by an alarming increase among women. Obesity is one of the risk factors of heart failure. VOA

“Research suggests that obesity, or at least poor diet, may have been a significant contributor to the slowdown in the decline of cardiovascular disease deaths,” said Alan Lopez, Professor at the University of Melbourne.

“Each of these countries have very high levels of obesity. In Australia, close to one-third of adults are obese,” Lopez said.

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The researchers observed that obesity is the main risk factors for cardiovascular disease mortality — others include smoking, high blood pressure, high cholesterol and diabetes.

“Failure to address these issues could confirm the end of the long-term decline in cardiovascular disease deaths and threaten future gains in life expectancy.” concluded study’s co-author Tim Adair, a researcher at the varsity. (IANS)