Monday September 24, 2018

Leukaemia: Genetics Changes may Help Spot the Risk

These changes could be used collectively to develop a predictive test for AML risk

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Genetic variants on the X chromosome explain virtually identical amounts of variation in men and women. Pixabay
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Scientists may now identify people at high risk of developing leukemia almost five years before the patient develops the cancer using a blood test to track some changes in the DNA code, which may reveal the roots of the disease among healthy people.

The findings showed that people who were en route to developing acute myeloid leukemia (AML) — blood cancer that affects the bone marrow and stops the production of normal blood cells — had a higher number of mutations in genes associated with the disease and the mutations were often present in a larger fraction of their blood cells.

“Acute myeloid leukemia often appears very suddenly in patients, so we were surprised to discover that its origins are generally detectable more than five years before the disease develops,” said joint first author Grace Collord from Wellcome Sanger Institute in Britain.

“This provides proof-of-principle that it may be possible to develop tests to identify people at a high risk of developing AML,” Collord, who is also a researcher at the University of Cambridge, added.

For the study, published in the journal Nature, the team sequenced stored blood DNA from 124 AML patients and compared it to that from 676 people who did not have AML or any related cancer.

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Representational image. Pixabay

The results showed that many of the people who went on to develop the cancer, had particular genetic changes that set them apart from those who did not.

These changes could be used collectively to develop a predictive test for AML risk. Specific blood test results were also subtly different among those who later developed the disease.

Also Read: New Link Found Between Alcohol, Genes And Heart Failure

“Our study provides for the first time evidence that we can identify people at risk of developing AML many years before they actually develop this life-threatening disease,” said joint project leader George Vassiliou from Wellcome Sanger Institute.

“We hope to build on these findings to develop robust screening tests for identifying those at risk and drive research into how to prevent or stall progression towards AML,” Vassiliou added. (IANS)

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Living near highway may increase leukaemia risk in kids: Study

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London: Living in the proximity of heavily-used roads may increase risk of a type of leukaemia in children, according to research. Exposure to benzene related to car traffic might be one of the explanations for this association, the study said. The researchers examined all 2,760 cases of childhood leukemia diagnosed in metropolitan France between 2002 and 2007, and compared them to a contemporary sample of 30,000 control children.

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indianexpress.com

 

The results showed that the incidence of new cases of myeloblastic leukaemia (418 of 2,760 cases of leukaemia) was 30 percent higher in children in the population whose residence was located within 150 m of heavily used roads, and had a combined length of over 260 m within this radius. In contrast, this association was not observed for the more common, lymphoblastic type of leukaemia (2,275 cases).

“The frequency of myeloblastic type leukaemias was 30 percent higher in children living within a 150 m radius of heavily used roads, and where the combined length of road sections within this radius exceeded 260 m,” said one of the researchers, Jacqueline Clavel, from French Institute of Health and Medical Research (INSERM). The increased risk of myeloblastic leukaemia for adults with a history of occupational exposure to benzene has long been known, the study pointed out. The findings were published in the American Journal of Epidemiology.

(IANS)