Sunday June 16, 2019

Leukemia Progression in Kids Can be Delayed Through Bone Density Treatment

Targeting a bone loss mechanism that occurs during the development of leukemia may hold the key to reducing the progression of the disease in children, researchers have found. Leukemia is a cancer of blood-forming tissues, hindering the body's ability to fight infection.

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Our finding that the cells surrounding the leukemia cells can contribute to treatment failure or success has led to a paradigm shift.
Hospital Beds. pixabay

Targeting a bone loss mechanism that occurs during the development of leukemia may hold the key to reducing the progression of the disease in children, researchers have found.

Leukemia is a cancer of blood-forming tissues, hindering the body’s ability to fight infection.

The study focused on the most common form of cancer in children, a subtype of acute lymphoblastic leukemia and witnessed substantial bone loss during its development, Xinhua news agency reported.

Children and adults treated with oral antibiotics may have a higher risk of developing kidney stones, according to a new study.
Representational Image, Pixabay

The pre-clinical findings from identifying the mechanism were promising and suggested that targeting the microenvironment around leukemia cells could not only help fight the cancer, but “simultaneously provide relief for one of its most common and painful side-effects, bone loss”, said lead author Laurence Cheung, a researcher from the Telethon Kids Cancer Centre, West Perth in Australia.

In the study, published in the journal Leukemia, the team identified a signal produced by the leukemia cells which instructed cells in the microenvironment to eat away at the bone.

The researchers then used a commercially available drug to target the cells in the microenvironment around the leukemia cells.

Our finding that the cells surrounding the leukemia cells can contribute to treatment failure or success has led to a paradigm shift.
Representational image, pixabay

“Importantly, we found that this not only compensated for the leukemia-dependent bone fragility, but also reduced leukemia progression,” Cheung said.

“To date, the main strategy for cancer therapy in children has focused on targeting malignant cells with chemotherapy, which is toxic for the leukemia cells but also toxic for the patient.

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“Our finding that the cells surrounding the leukemia cells can contribute to treatment failure or success has led to a paradigm shift.

“It means this potentially could be a powerful adjuvant therapy. It’s not going to replace chemotherapy, but we propose that using chemotherapy and treating the microenvironment at the same time will have more benefit than just the chemotherapy by itself,” Cheung said. (IANS)

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GRAIL Announces Significant Progress on Blood Tests to Detect Cancer

Grail's new results are from 2,300 people

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GRAIL, Blood Tests, Detect, Cancer
FILE A patient has her blood drawn at a hospital in Philadelphia to monitor her cancer treatment. VOA

A California company says its experimental blood test was able to detect many types of cancer at an early stage and gave very few false alarms in a study that included people with and without the disease.

Many companies are trying to develop early detection “liquid biopsy” tests that capture bits of DNA that cancer cells shed into blood.

GRAIL, Blood Tests, Detect, Cancer
A California company says its experimental blood test was able to detect many types of cancer at an early stage. VOA

Grail’s new results are from 2,300 people. The test detected 55% of known cancers and gave false alarms for 1%. It also accurately suggested where the cancer may be about 90% of the time.

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The company gave results in news release Friday and will report them Saturday at a conference in Chicago. They have not been published or reviewed by other scientists. (VOA)