Wednesday March 20, 2019

Leukemia Progression in Kids Can be Delayed Through Bone Density Treatment

Targeting a bone loss mechanism that occurs during the development of leukemia may hold the key to reducing the progression of the disease in children, researchers have found. Leukemia is a cancer of blood-forming tissues, hindering the body's ability to fight infection.

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Our finding that the cells surrounding the leukemia cells can contribute to treatment failure or success has led to a paradigm shift.
Hospital Beds. pixabay

Targeting a bone loss mechanism that occurs during the development of leukemia may hold the key to reducing the progression of the disease in children, researchers have found.

Leukemia is a cancer of blood-forming tissues, hindering the body’s ability to fight infection.

The study focused on the most common form of cancer in children, a subtype of acute lymphoblastic leukemia and witnessed substantial bone loss during its development, Xinhua news agency reported.

Children and adults treated with oral antibiotics may have a higher risk of developing kidney stones, according to a new study.
Representational Image, Pixabay

The pre-clinical findings from identifying the mechanism were promising and suggested that targeting the microenvironment around leukemia cells could not only help fight the cancer, but “simultaneously provide relief for one of its most common and painful side-effects, bone loss”, said lead author Laurence Cheung, a researcher from the Telethon Kids Cancer Centre, West Perth in Australia.

In the study, published in the journal Leukemia, the team identified a signal produced by the leukemia cells which instructed cells in the microenvironment to eat away at the bone.

The researchers then used a commercially available drug to target the cells in the microenvironment around the leukemia cells.

Our finding that the cells surrounding the leukemia cells can contribute to treatment failure or success has led to a paradigm shift.
Representational image, pixabay

“Importantly, we found that this not only compensated for the leukemia-dependent bone fragility, but also reduced leukemia progression,” Cheung said.

“To date, the main strategy for cancer therapy in children has focused on targeting malignant cells with chemotherapy, which is toxic for the leukemia cells but also toxic for the patient.

Also Read: Effective Treatment to Protect Cancer Patients From Blood Clots

“Our finding that the cells surrounding the leukemia cells can contribute to treatment failure or success has led to a paradigm shift.

“It means this potentially could be a powerful adjuvant therapy. It’s not going to replace chemotherapy, but we propose that using chemotherapy and treating the microenvironment at the same time will have more benefit than just the chemotherapy by itself,” Cheung said. (IANS)

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Beware! Sipping Hot Tea Raises Risk of Esophageal Cancer

Esophageal cancer is the sixth most common cancer in India and eighth most globally. It affects more men than women.

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Scalding water irritates the lining of the mouth and throat which can fuel tumours, scientists believe. Pixabay

Love to drink your tea piping hot? Beware, it could raise the risk of esophageal cancer, finds a study.

The study showed that risk of esophageal cancer more than doubled among those who regularly drank tea at 75 degrees Celsius

However, waiting for at least four minutes before drinking a cup of freshly boiled tea can reduce the risk of the cancer arising from the oesophagus — the food pipe that runs between the throat and the stomach.

“Many people enjoy drinking tea, coffee, or other hot beverages. However, according to our report, drinking very hot tea can increase the risk of esophageal cancer, and it is therefore advisable to wait until hot beverages cool down before drinking,” said lead author Farhad Islami of the American Cancer Society.

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The study showed that risk of esophageal cancer more than doubled among those who regularly drank tea at 75 degrees Celsius. Pixabay

The study, published in the International Journal of Cancer, involved 50,045 individuals aged 40 to 75 years.

Drinking 700 ml per day of tea or more at a higher temperature (60 degrees Celsius or higher) was associated with a 90 per cent higher risk of esophageal cancer, the researchers said.

The results could also be extended to coffee, hot chocolate or other hot beverages.

Esophageal cancer is the sixth most common cancer in India and eighth most globally. It affects more men than women.

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The results could also be extended to coffee, hot chocolate or other hot beverages. pixabay

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In 2016, the World Health Organisation (WHO) had warned of the cancer risk associated with drinks above 65 degrees Celsius.

Scalding water irritates the lining of the mouth and throat which can fuel tumours, scientists believe. (IANS)