Saturday October 19, 2019

Leukemia Progression in Kids Can be Delayed Through Bone Density Treatment

Targeting a bone loss mechanism that occurs during the development of leukemia may hold the key to reducing the progression of the disease in children, researchers have found. Leukemia is a cancer of blood-forming tissues, hindering the body's ability to fight infection.

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Our finding that the cells surrounding the leukemia cells can contribute to treatment failure or success has led to a paradigm shift.
Hospital Beds. pixabay

Targeting a bone loss mechanism that occurs during the development of leukemia may hold the key to reducing the progression of the disease in children, researchers have found.

Leukemia is a cancer of blood-forming tissues, hindering the body’s ability to fight infection.

The study focused on the most common form of cancer in children, a subtype of acute lymphoblastic leukemia and witnessed substantial bone loss during its development, Xinhua news agency reported.

Children and adults treated with oral antibiotics may have a higher risk of developing kidney stones, according to a new study.
Representational Image, Pixabay

The pre-clinical findings from identifying the mechanism were promising and suggested that targeting the microenvironment around leukemia cells could not only help fight the cancer, but “simultaneously provide relief for one of its most common and painful side-effects, bone loss”, said lead author Laurence Cheung, a researcher from the Telethon Kids Cancer Centre, West Perth in Australia.

In the study, published in the journal Leukemia, the team identified a signal produced by the leukemia cells which instructed cells in the microenvironment to eat away at the bone.

The researchers then used a commercially available drug to target the cells in the microenvironment around the leukemia cells.

Our finding that the cells surrounding the leukemia cells can contribute to treatment failure or success has led to a paradigm shift.
Representational image, pixabay

“Importantly, we found that this not only compensated for the leukemia-dependent bone fragility, but also reduced leukemia progression,” Cheung said.

“To date, the main strategy for cancer therapy in children has focused on targeting malignant cells with chemotherapy, which is toxic for the leukemia cells but also toxic for the patient.

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“Our finding that the cells surrounding the leukemia cells can contribute to treatment failure or success has led to a paradigm shift.

“It means this potentially could be a powerful adjuvant therapy. It’s not going to replace chemotherapy, but we propose that using chemotherapy and treating the microenvironment at the same time will have more benefit than just the chemotherapy by itself,” Cheung said. (IANS)

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Being Overweight Before the Age of 40 Can Increase Risk of Cancer in Adults

"The risk increased by 64 per cent for male participants and 48 per cent for females," Bjorge added

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Cancer
Cancer Ribbon. Pixabay

Researchers have found that being overweight before the age of 40 could increase the risk of various cancers in adults.

“Obesity is an established risk factor for several cancers. In this study, we have focused on the degree, timing and duration of overweight and obesity in relation to cancer risk,” said study author Tone Bjorge, Professor at University of Bergen in Norway.

For the findings, published in the International Journal of Epidemiology, the research team wanted to find out how adult overweight (BMI over 25) and obesity (BMI over 30) increase the risk of different types of cancer.

The researchers used data for 2,20,000 individuals from the Me-Can study, with participants from Norway, Sweden and Austria.

Data from health examinations, including information on height and weight, were linked to data from national cancer registries.

Obesity
An overweight woman sits on a chair in Times Square in New York, May 8, 2012. VOA

According to the researchers, 27,881 individuals were diagnosed with cancer during follow-up, of which 9,761 (35 per cent) were obesity-related.

The study showed that if you were overweight before age 40, the risk of developing cancer increases by: 70 per cent for endometrial cancer, 58 per cent for male renal-cell cancer, 29 per cent for male colon cancer and 15 per cent for all obesity-related cancers (both sexes).

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Obese participants (BMI over 30) at the first and second health examination had the highest risk of developing obesity-related cancer, compared to participants with normal BMI.

“The risk increased by 64 per cent for male participants and 48 per cent for females,” Bjorge added. (IANS)