Researchers have found a new molecular link between oestrogen and bone ageing, which may eventually lead to new strategies to treat osteoporosis among post-menopausal women.
Osteoporosis is a condition in which bones become weak and prone to fractures.
Women over 50 are at a high risk of developing osteoporosis, which may be due to the loss of oestrogen that occurs after menopause.
“Over the last few decades, we’ve learned that oestrogen plays an important role in maintaining a functional bone matrix,” said Tomoki Nakashima from the Tokyo Medical and Dental University (TMDU) in Japan.
However, how oestrogen does this, was not fully understood, the researchers said.
In the study, the researchers discovered a protein called Sema3A, which was found to maintain bone matrix — proteins and minerals in bone — suggesting a relationship between oestrogen and Sema3A.
Further, the researchers found that blood serum levels of the protein Sema3A decreased in pre-menopausal women as they get older and dropped even more once they reach menopause.
In the study done on mice, the ovaries of mice were removed but it was found that the loss of oestrogen did not prevent their bones from deteriorating.
In addition, Sema3A was found to promote the survival of osteocytes — bone cells — in these mice.
“We believe that as women lose oestrogen with age and Sema3A levels drop, osteocytes begin to die and bone loses the ability to maintain its supportive structure,” Mikihito Hayashi from the varsity said. (IANS)
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1. Weight training benefits women
Most women feel weight training is solely the preserve of men. But this couldn’t be farther from the truth. Training weights not only builds physical strength for women, but also it’s the best way for women to improve their overall health and well-being, lose body fat and manage their body weight better, and improve the shape of their body.
2. It is one of the fastest ways to lose fat
Most women solely focus on cardio as a way to lose body fat. While this is a useful fat loss tool, weight training is a much more time-efficient and effective way of losing body fat. Whereas, cardio only burns calories, weight training will burn calories but also build muscle tissue which increases metabolic rate, whilst also improving the shape of your body.
3. It is one of the best ways to drastically improve your body confidence
Training with weights is the best way for any woman to improve her body confidence. When you feel lean and strong, you look good and your clothes fit better, this has a positive impact on the way that you feel in everyday life.
4. It will give you an incredible mental boost
The physical strength that you can build through lifting weights has massive carryover into your everyday life — and not just in terms of body confidence.
A 2018 study from the University of Limerick in the journal JAMA Psychiatry, showed that strength training showed improvements in depressive symptoms such as low mood, feelings of worthlessness and loss of interest in activities.
5. Weight training is an effective way to strengthen your bones
As women age, particularly beyond menopause, the risk of degenerative bone diseases, such as osteoporosis, increases. Studies show that weight training is an effective way to help prevent bone loss and reduce the risk of osteoporosis-related fractures, which can have serious health and mobility implications later in life.
6. It is a great way to balance your hormones
Weight training is brilliant for women that struggle with their hormones. Firstly, lifting weights can help improve your body’s insulin response. This can help with circulating cortisol levels (a stress hormone), helps your hormones and helps make your tissues healthier and your body detoxify better.
Xenoestrogen levels are likely to come down too, and it can bring down systemic inflammation. For anyone with blood sugar management problems, such as pre-diabetes or diabetes, weight training can improve their body’s response to insulin. Many women who suffer from PCOS often suffer with insulin resistance and elevated insulin levels can cause hormonal imbalances. Weight training can improve this and help ameliorate PCOS symptoms, one of which is problems losing weight.