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Daily low-dose aspirin, from as early as the sixth week of pregnancy through the 36th week, may lower the risk of preterm birth among first-time mothers, suggest the results of a clinical trial which involved women from several low and middle-income countries, including India.
The study, published in the journal The Lancet, involved more than 11,000 women.
The results showed that women taking daily low-dose aspirin were 11 per cent less likely to deliver before the 37th week of pregnancy, compared to those given a placebo.
“Our results suggest that low-dose aspirin therapy in early pregnancy could provide an inexpensive way to lower the preterm birth rate in first-time mothers,” said study author Marion Koso-Thomas of the US National Institutes of Health’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
Preterm birth is the most common cause of infant death and the leading cause of long-term neurological disability in children.
According to the study authors, advances in newborn care have improved survival for preterm infants, but this care is limited or unavailable in many parts of the world.
Earlier studies have suggested that low-dose aspirin may reduce the risk of preterm birth and pre-eclampsia, a potentially life-threatening blood pressure disorder of pregnancy.
However, these studies were not large enough to statistically determine the therapy’s effectiveness in reducing preterm birth.
The researchers enrolled 11,976 women with a first-time pregnancy from seven sites in India, Pakistan, Zambia, Democratic Republic of the Congo, Guatemala and Kenya.
Roughly half were assigned at random to receive 81 milligrams of aspirin daily; the other group received a daily placebo. Women were included in the study only if they maintained a pregnancy for more than 20 weeks.
Preterm birth (before 37 weeks) occurred in 11.6 per cent of the women who took aspirin and in 13.1 per cent of the women who took the placebo.
Similarly, birth before 34 weeks (early preterm delivery) occurred in 3.3 per cent of the aspirin group and 4 per cent of the placebo group (a 25 per cent reduction).
Women in the aspirin group also had a lower rate of perinatal mortality (stillbirth or newborn death in the first seven days of life), compared to the placebo group (45.7 per 1,000 births vs 53.6 per 1,000 births).
The risk of high blood pressure disorders of pregnancy at term did not differ significantly between the groups.
The low cost and safety of low-dose aspirin therapy suggests that it could be easily adapted for wide-scale use, suggested the study authors. (IANS)
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