Sunday November 17, 2019

Study Finds that Lower Level of Physical Activity can Increase Death Rates among People

The study was published in the Journal of the American Geriatrics Society

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Physical Activity
Physical Activity is important for avoiding early death in older men and women, the study said. Pixabay

Researchers have found the people who had the lowest levels of Physical Activity had higher rates of death compared to people with higher levels of activity, adding that nine per cent of all premature deaths are caused by not getting enough physical activity.

Physical activity is known to reduce deaths from heart disease, diabetes, chronic lung disease, and mental illness.

For the findings, the research team from Federal University of Pelotas in Brazil, looked more carefully at the relationship between death and physical exercise among older adults in Brazil (where the number of older adults grew 40 per cent between 2002 and 2012).

The study was published in the Journal of the American Geriatrics Society.

During the study, from January to August 2014, researchers conducted home interviews with 1,451 adults older than 60. Of these, 971 participants were given wrist monitors to measure their physical activity.

Researchers also asked participants about their smoking habits and how they would rate their health.

Additionally, researchers learned about the chronic health conditions participants said they had, including high blood pressure, diabetes, heart problems, Parkinson’s disease, kidney failure, high cholesterol, depression, stroke, and cancer.

Physical Activity
Researchers have found the people who had the lowest levels of Physical Activity had higher rates of death compared to people with higher levels of activity. Pixabay

The researchers then rated participants’ ability to perform their normal daily activities, including bathing, dressing, getting from bed to chair, going to the bathroom, and feeding.

The researchers concluded that their main findings suggest that low levels of physical activity are associated with higher risks of death, no matter what a person’s level of health was.

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Overall, physical activity was important for avoiding early death in older men and women, the study said. (IANS)

Next Story

Immune Cells Become Active and Repair Brain While Sleep: Study

For the findings, researchers conducted the study on mice

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Sleep
Study suggests that the enhanced remodeling of neural circuits and repair of lesions during Sleep may be mediated in part by the ability of microglia to dynamically interact with the Brain. Pixabay

Researchers have found that immune cells called microglia, which play an important role in reorganising the connections between nerve cells, fighting infections, and repairing damage, are also primarily active while we sleep.

Microglia serve as the brain’s first responders, patrolling the brain and spinal cord and springing into action to stamp out infections or gobble up debris from dead cell tissue.

“This research shows that the signals in our brain that modulate the sleep and awake state also act as a switch that turns the immune system off and on,” said study lead author Ania Majewska, Professor at University of Rochester in the US.

In previous studies, Majewska’s lab has shown how microglia interact with synapses, the juncture where the axons of one neuron connects and communicates with its neighbours.

The microglia help maintain the health and function of the synapses and prune connections between nerve cells when they are no longer necessary for brain function.

For the findings, researchers conducted the study on mice.

The current study points to the role of norepinephrine, a neurotransmitter that signals arousal and stress in the central nervous system.

This chemical is present in low levels in the brain while we sleep, but when production ramps up it arouses our nerve cells, causing us to wake up and become alert.

The study showed that norepinephrine also acts on a specific receptor, the beta2 adrenergic receptor, which is expressed at high levels in microglia.

When this chemical is present in the brain, the microglia slip into a sort of hibernation.

Sleep
Researchers have found that immune cells called microglia, which play an important role in reorganising the connections between nerve cells, fighting infections, and repairing damage, are also primarily active while we Sleep and affects Brain. Pixabay

The study, which employed an advanced imaging technology that allows researchers to observe activity in the living brain, showed that when mice were exposed to high levels of norepinephrine, the microglia became inactive and were unable to respond to local injuries and pulled back from their role in rewiring brain networks.

“This work suggests that the enhanced remodeling of neural circuits and repair of lesions during sleep may be mediated in part by the ability of microglia to dynamically interact with the brain,” said study first author Rianne Stowell.

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“Altogether, this research also shows that microglia are exquisitely sensitive to signals that modulate brain function and that microglial dynamics and functions are modulated by the behavioural state of the animal,” Stowell said.

The study was published in the journal Nature Neuroscience. (IANS)