Thursday, September 24, 2020
Home Life Style Health & Fitness Males Have Higher Risk of Suffering from Cancer: Study

Males Have Higher Risk of Suffering from Cancer: Study

Researchers explain why cancer risk is higher in males

DNA differences between men and women may explain why cancer risk is higher in males, according to a new study.

In findings published in the Journal of the National Cancer Institute, researchers have reported that loss of function in certain genes of the sex-determining Y chromosome, which is present only in men, may cause them to have an elevated risk for cancer.

Using data from 9,000 individuals, the researchers studied Y-chromosome gene function in patients with various types of cancer. The findings showed that cancer risk increases with loss of function of six key Y-chromosome genes in various types of cells.

“Recent studies have shown that complete loss of the Y chromosome, which is essential to foetal sex differentiation, occurs, with aging, in the cells of some men,” said study author Juan Ramon Gonzalez from Barcelona Institute for Global Health in Spain.

Cancer DNA
Suppression of the Y chromosome can occur as a result of loss of function in the chromosome. Pixabay

“Although the loss of the Y chromosome has previously been associated with higher incidence of cancer, the causes of this association are poorly understood,” Gonzalez added.

These six Y-chromosome genes are involved in cell-cycle regulation, the failure of which can lead to tumour development.

According to the study, understanding the biological differences between men and women in cancer is crucial for the development of personalised lines of treatment and prevention.

“Men are not only at higher risk of cancer than women, they also face a worse prognosis. In fact, these differences partially account for the lower life expectancy of men,” Gonzalez added.

According to the researchers, although men may be more exposed to carcinogens due to the type of work they do and at higher risk because they are less likely to consult a doctor, the study has shown that there are also biological factors that increase cancer risk among men.

“In fact, it seems that one of these factors can be found in the Y chromosome, the very essence of maleness,” said study lead author Alejandro Caceres.

Also Read- Know About the Health Benefits of Green Tea

Suppression of the Y chromosome can occur as a result of loss of function in the chromosome, which would explain previous findings, or as a result of other mechanisms mediated by the chemical (epigenetic) inactivation of the same regions, the research said.

“Certain environmental exposures, for example to tobacco or other harmful substances, could affect chromosome function and lead to epigenetic modifications,” Gonzalez said. (IANS)

STAY CONNECTED

19,143FansLike
362FollowersFollow
1,774FollowersFollow

Most Popular

Microsoft Study Shows Pandemic has Increased Feeling of Burnout Among Workers

If you've been feeling overwhelmed at work lately, you are not alone as a new Microsoft study has shown that the pandemic has increased...

Lower Zinc Levels in Blood Linked to Higher Death Risk in Covid Patients: Study

In a major study, researchers have found that having a lower level of zinc in the blood is associated with a poorer outcome in...

Time Magazine List of 100 Most Influential People: Ayushmann Khurrana Among 5 Indians

Indian actor Ayushmann Khurrana is in the Time magazine list of 100 Most Influential People this year. Follow NewsGram on LinkedIn to know what's happening...

Return to Usual Sexual Activity After Heart Attack for Long-Term Survival

Returning to usual levels of sexual activity within a few months after a heart attack is positively associated with long-term survival, say researchers. According to...

Researchers Find Potential New Drug Candidate Against Enterovirus

Some good news in the search for antiviral drugs for hard-to-treat diseases as researchers have identified a potential new drug candidate against enterovirus 71,...

Stroke Patients With Covid-19 Show Increased Inflammation, Death Rate: Researchers

Stroke patients who also have Covid-19 showed increased systemic inflammation, more serious stroke severity and a much higher rate of death, compared to stroke...

Playing Video Games in Childhood Can Improve Working Memory Years Later

In a good news to video game lovers, researchers have found that playing video games as a child can improve working memory years later. The...

Know the Negative Impact of Covid-19 Lockdown on Kids

Children, who appear at a relatively lower risk from Covid-19, are disproportionately harmed by precautions involved with lockdowns, warn researchers. Experts from Oxford University Hospitals...

Recent Comments