Tuesday, September 22, 2020
Home Education Mechanisms That Deteriorate Immunity During COVID'19

Mechanisms That Deteriorate Immunity During COVID’19

"These findings are extremely exciting. Our data show that T cells could be manipulated during early stages of severe viral infection to improve their activity," the study authors noted

In a major study, Australian researchers have identified mechanisms leading to the functional deterioration of immunity in response to severe viral infections, such as HIV or Covid’19.

It is widely known that severe viral infections and cancer cause impairments to the immune system, including to T cells, a process called immune ‘exhaustion’.

According to the study, published in the journal Nature Immunology, overcoming immune exhaustion is a major goal for the development of new therapies for cancer or severe viral infections.

“This is an exciting finding, particularly in the context of Covid-19 as one of the big questions is why some people get severely sick, while others experience mild disease,” said study author Daniel Utzschneider from the University of Melbourne in Australia.

Immunity
Positive emotions and a healthy lifestyle may boost your immunity. Unsplash

For the findings, the research team focused on the question of when and how T cells lose their function and become ‘exhausted’.

It was previously thought that during severe infections, T cells lost their function slowly and over long periods of time.

This research, however, shows that T cells can be impaired within just a few days. It also identified several new mediators of immune exhaustion that may be targeted in new therapies.

“We looked at both mild and overwhelming Lymphocytic Choriomeningitis Virus infections in mice, which serves as a model for severe viral infections in humans, early after the onset of disease, and identified striking differences at the molecular and functional level,” Utzschneider said.

In response to overwhelming infections that are difficult to eliminate and may become chronic, the team were able to show that T cells down-regulate their function within days, while T cells responding to a weaker infection remained highly functional.

Also Read: Quick Tips To Ace Digital Learning

T cells are at the heart of immunotherapy for cancer. Therefore, understanding how a T cell function is impaired is central to improving these therapeutic approaches and applying them to other diseases, such as viral infections, they said.

“These findings are extremely exciting. Our data show that T cells could be manipulated during early stages of severe viral infection to improve their activity,” the study authors noted. (IANS)

STAY CONNECTED

19,143FansLike
362FollowersFollow
1,775FollowersFollow

Most Popular

Here’s How The Art of “Writing” Became an Empowerment Tool For These Female Authors

By Siddhi Jain Being a female author can come with its own set of challenges, especially when one is trying to juggle a career in...

Self-Driving Cars To Navigate Rush Hour Traffic On This Planet: NASA

A laser-based technology designed to help spacecraft land on a proverbial dime for missions to the Moon and Mars is also helping self-driving cars...

Choose Correct Diet And Workout To Stay Motivated: Actor Sunny Singh

Actor Sunny Singh says when you choose the correct diet and workout, you will always be motivated. "It's been quite a long that I've been...

ICAR Builds Technology To Make Bacteriophages To Control Shrimp Diseases

The ICAR-Central Institute of Brackishwater Aquaculture (CIBA) on Monday said it has transferred its technology to make bacteriophages, or viruses that eat bacteria, to...

NEP Arrived When India Is Redefining Itself As “Atmanirbhar Bharat”

The New Education Policy (NEP) has infused a new wave of optimism with the vision of strengthening the education system, branching out into varied...

Venom Of Largest Spiders To Help Irritable Bowel Syndrome Patients

The venom from one of the largest spiders in the world may bring the hope to ease the gut pain suffered by millions of...

Ketogenic Diet May Reduce Risk of Alzheimer’s Disease

Eating healthy, low calorie food could help fight the fungi in the gut and thus reduce the risk of dementia among senior citizens, doctors...

45% of the Top 100 Google Searches Related to Travel Amid Pandemic

After living months in isolation during the pandemic, the travel bug has hit millions of people and according to Google, 45 per cent of...

Recent Comments