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Cognitive decline is a major concern of the aging population. Already, Alzheimer’s disease affects approximately 5.4 million Americans and 30 million people globally. Without effective prevention and treatment, the prospects for the future are bleak. By 2050, it is estimated that 160 million people globally will have the disease, including 13 million Americans, leading to potential bankruptcy of the Medicare system. Unlike several other chronic illnesses, Alzheimer’s disease is on the rise–recent estimates suggest that Alzheimer’s disease has become the third leading cause of death in the United States behind cardiovascular disease and cancer. Since its first description over 100 years ago, Alzheimer’s disease has been without effective treatment. While researchers continue to seek out a cure, it is becoming clear that there are effective treatment options. More and more research supports the conclusion that Alzheimer’s disease is not a disease of only Beta-Amyloid plaques and Tao tangles but a complex and systemic disease. In this study of patients with varying levels of cognitive decline, it is demonstrated how a precision and personalized approach results in either stabilization or improvement in memory.
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Interventions to stop the progression of Alzheimer’s disease have been marginally successful at best. This study uses a more comprehensive, personalized approach addressing each participant’s unique risk factors. “The findings, published in the Journal of Alzheimer’s Disease Reports (Journal of Alzheimer’s DiseaseReports4(1)), are encouraging and indicate that a more extensive clinical study is warranted”, said Brian Kennedy, Ph.D., Director of The Centre for Healthy Aging, National University Health System, Singapore and Chief Scientific Officer, Affirmative Health.
The Affirmative Health scientific team, after a thorough review of published research, has developed a comprehensive approach to addressing scientifically supported risk factors that have been rigorously defined as interventions to promote prevention, increased resiliency, and stabilization of brain function in the realm of AD and dementia. Utilizing cutting edge technology in concert with in-person coaching and consultation, we are demonstrating that a multi-modal and personalized approach promotes an improved resiliency and restoration of optimal brain function. The personalized therapeutic program includes genetics, an extensive blood panel, medical history, and lifestyle data to evaluate relevant metabolic risk factors and nutrient levels associated with cognitive health. “Target laboratory levels differ from standard laboratory ranges as the goal is to reach optimized levels for cognitive health”, Ginger Schechter, MD, Chief Medical Officer, Affirmative Health
The study approach considers more than 35 factors known to contribute to cognitive decline. Results demonstrate that certain of those factors are more affected than others again demonstrating the need for a more precise treatment plan. “This study supports the need for an approach that focuses on a one-size-fits one, not a one-size-fits-all, approach that comprehensively assesses all involved risk factors affecting memory loss”, Denise M Kalos, CEO Affirmative Health
In conjunction with the publication of this vital study, and to expose alternative treatment options for Alzheimer’s disease and cognitive decline, the team at Affirmative Health has written a book, Outsmart your Brain – an Insider’s Guide to Life-Long Memory. “Memory is not something that should diminish with age; you are never too young to start developing healthy habits that can ultimately impact your cognition,” Outsmart Your Brain. This book leverages the foundation of Affirmative Health’s research to deliver tips and tools guide for the maintenance of good cognitive health. “Far too few people understand how critical lifestyle and dietary choices are for brain function. ‘Outsmart Your Brain’ is an important tool to get this information into the hands of those who should know it, everyone!, in easy-to-understand language”, Ryan R. Fortna, MD, Ph.D., Chief Medical/Scientific Officer, ADx Healthcare. (AlphaGalileo)
London (CNN)- At five o'clock in the morning, the esteemed 86-year-old astrophysicist Jim Peebles was woken suddenly by the telephone ringing."In previous experience, the only phone calls at that time of night are bad news," he said. This one was great news. "The opening sentence from the caller was: 'The Nobel committee has voted to award you the Nobel Prize in Physics. Do you accept?'" Peebles recalled. The wording threw him. Who wouldn't accept a Nobel Prize? "You know the Bob Dylan fiasco?" he said during a phone interview with CNN. "That might have put the wind up them."The "fiasco" Peebles mentions refers to the 2016 Nobel Prize in Literature, which was controversially given to an utterly unimpressed Dylan.Aside from being ever-presents on college campuses in the 1960s, little connects Peebles, an expert in theoretical cosmology, with Dylan. But one of the starkest contrasts might lie in their reactions to winning a Nobel -- and the songwriter is far from the only laureate whose crowning turned out to be an awkward affair.
The five committees are notoriously secretive, fiercely shielding their choices from the outside world -- including the laureates themselves, who are told of their victories just minutes before they are announced to the public.
Jim Peebles speaking at the Nobel Prize banquet in 2019 Image credit: CNN
That tight-lipped mantra can lead to some heartening surprises, as it did for Benjamin List -- the co-winner of this year's Nobel Prize in Chemistry -- who was having coffee with his wife when he received the news.
"Sweden appears on my phone, and I look at her, she looks at me and I run out of the coffee shop to the street ... you know, that was amazing. It was very special. I will never forget," he told reporters on Wednesday after his victory was announced.It can also be far less celebratory. "I was lying in bed, and my wife woke up and heard my phone buzzing. And she yelled at me because my phone was waking her up," David MacMillan, who shared the prize with List, told BBC Radio 4 on Thursday."100% [I] missed the call. Classic Scottish person. I [didn't] believe this is happening, so I went back to bed," he added -- likely the most relatable sentence ever uttered by an expert in chiral imidazolidinone catalysts.
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And for some, the sudden ascension to Nobel laureate is an unwanted intrusion altogether. "Oh Christ," British-Zimbabwean author Doris Lessing said when reporters arrived outside her house to inform her she had won the Nobel Prize in Literature in 2007. "I'm sure you'd like some uplifting remarks of some kind. "It's a wonderful thing," Reinhard Genzel, an astrophysicist who won last year's Nobel Prize in Physics, told CNN of his win and the months since. "But it's a chore as well."
What it's like to win a Nobel PrizeFew Nobel winners can honestly say their lives weren't changed when they received the phone call.As long as they believe it, that is. "These days you get these cold calls, and I thought this is another one of them," Abdulrazak Gurnah, the winner of this year's literature prize, told the BBC on Thursday."This guy said, 'Hello, you have won the Nobel Prize for Literature,' And I said, 'come on, get out of here. Leave me alone,'" Gurnah said. "He talked me out of that, and gradually persuaded me."Winners often can't be contacted at all, leaving them to find out about their wins from the news, their family, or even their next-door neighbors.
Nobel Peace Prize winners Ressa and Muratov Image source: CNNEconomist Paul Milgrom was woken in the middle of the night in California by his colleague Robert Wilson banging on his front door. "Paul, it's Bob Wilson. You've won the Nobel Prize," he shouted into the intercom. "Yeah, I have? Wow," an utterly confused Milgrom responded, in an exchange captured by a doorbell camera.
Genzel's phone call came while he was in a Zoom meeting with colleagues last October. "I had absolutely no inkling," he said. "I thought, my God ... obviously this is a fantasy."
The committee's secretary told him he "couldn't say anything for 15 or 20 minutes," so Genzel tried his best to keep the news to himself. "I walked over to our meeting room ... (my colleagues) told me afterwards I was stumbling in there, slightly gazed, telling them to switch on the TV," he said.Malala Yousafzai, the youngest Nobel winner at 17, was midway through a chemistry lesson at a school in Birmingham, England, when a teacher interrupted to tell her she had won, she told Reuters.She later told Vogue that she modestly left the achievement off her university applications, because she "felt a bit embarrassed." But there are occasions, too, where the winner isn't quite as thrilled as the Nobel committee might imagine.
Dylan and Ernest Hemingway both skipped the Nobels' annual banquet; the latter made a point of telling the Swedish Academy that he had "no facility for speech making and no command of oratory." But arguably it was Lessing who had the most memorable reaction. She learned of her win as she stepped out of a taxi on the way back from the grocery store. "Have you heard the news? You've won the Nobel Prize for Literature!" an enthusiastic reporter told her. Her eyes rolled back in her head before the journalist had even finished his sentence. Lessing -- accompanied by a male acquaintance who stood next to her, bemused, his arm in a sling and a single artichoke in his hand -- was clearly more interested in collecting her shopping than talking to the world's media.
Also read: Abdulrazak Gurnah- The New Nobel Laureate
Asked how she felt, she expressed little enthusiasm: "Look, I've won all the prizes in Europe, every bloody one."
"Am I supposed to get excited, or elated, or what?" she remarked. "One can't get more excited than one gets, you know?"
'I was treated like a rock star'
As soon as Genzel's win was announced last year, his face was on televisions around the world. The announcement of a Nobel Prize winner makes the front pages of newspapers and websites almost everywhere, throwing a sudden spotlight on little-known scientists and their complex research. "Once the announcement is made, you lose your identity within half an hour," Genzel said. "The telephone rings all the time. "Peebles had a similar experience just minutes after his early morning phone call. "When I returned to bed my wife said, 'What was that about?' I said 'Nobel Prize,' and she said: Oh God." Within minutes, the couple had a photographer outside their door. Genzel suddenly found himself answering questions about politics on late-night German TV, angering some of his friends with his responses. Peebles, meanwhile, spent much of the day looking through emails from every corner of the world: "Please come visit us, please read my manuscript..."
Reinhard Genzel posing with his medal Image source: CNN
"It's one thing to say that the Nobel Prizes attract attention. It's another to experience it," he said. Sometimes, personal relationships change. "There is of course a lot of envy, from some colleagues -- many people who are close to me in the same field might very well say, 'Why did he get it?'" said Genzel. But before the Covid-19 pandemic scuppered plans for two years in a row, winners were also treated to a gala in Stockholm. "I was treated like a rock star ... I experienced what I expect rock stars to experience," Peebles said of his banquet in 2019. "It's a wonderful honor." "My attache had an almost endless list of things to do," he added. "'Now you must meet these influential people. Now you must go to a news conference. Now we will have dinner with some important people. And on and on.' "Genzel missed out on the festivities last year, but he enjoyed a low-key affair in Germany. "The governor of Bavaria offered us his residence, (and) we had a fairly nice event with the Swedish ambassador," he said. Two years on, CNN asked Peebles whether his email inbox has finally receded to pre-Nobel volumes. "I'd have to look at the data on that," he responded, ever the empiricist. But for both men and many other laureates, the most exciting part of the Nobel experience is simply that it gets people talking about science and culture.
"I find it almost a necessity to tell the public at large that there is truth, there is absolute truth," Genzel said. "What I hope is understood is the importance of the Nobel Prize in making people aware of the importance of curiosity-driven science or arts," he said. "I think it must be unique."
(This article is originally written by Bob Picheta)
Keywords: Nobel Prize, Reactions, Laureates
Married Hindu women are recognised by a red streak of vermillion in the middle of their foreheads. This is traditionally called 'sindoor', which is derived from the Sanskrit word sindura, meaning 'red lead.'. Sindoor is traditionally powdered turmeric and lime, sometimes red saffron, or red sandalwood. It is also called vermilion, or Kumkum.
Sindoor is traditionally powdered turmeric and lime, sometimes red saffron, or red sandalwood. It is also called vermilion, or Kumkum. Image source: Photo by Gayathri Malhotra on Unsplash
The origin of the practise of wearing sindoor is ambiguous, but historical records from the Harappan civilisation show that women wore sindoor as a sign of being married. Today's generation considers the wearing of sindoor an outdated and patriarchal ritual. However, there is still a large population of women who uphold the ritual of adorning their foreheads with vermilion every day.
Sindoor implies the longevity of a woman's marriage to her husband in the Hindu tradition. The longer the streak, the longer her husband's life is believed to be. Women wear it for the first time on their wedding day, when the husband applies it during the ceremony. As long as he remains alive, the red streak that fills the woman's maang, or hair partition, symbolises her fruitful married life.
When the finger used to apply the sindoor touches the pituitary gland every time, it arouses affection in a woman for her husband. Image credit: Photo by Amish Thakkar on Unsplash
The components of the red powder are believed to improve the sexual energy of the woman. When the finger used to apply the sindoor touches the pituitary gland every time, it arouses affection in a woman for her husband. The mixture that she wears on her head controls her blood pressure and activates her sexual drive.
These days, feminists do not take very lightly to the practice of wearing sindoor, as they view it as a sign of patriarchal dominance. They do not like being branded as 'belonging to a man'. They prefer to wear it as a style statement because it enhances beauty. Fashion designers have recently commissioned models to sport sindoor on the runway. New age feminists are making bids to allow widows and single women to adorn their foreheads with the vermilion streak.
Keywords: Sindoor, Marriage, Symbol, Women, Patriarchy
Actress Urvashi Rautela has recently announced the name of her next film which is titled 'Dil Hai Gray'. It's a Hindi remake of Tamil film 'Thiruttu Payale 2'. Urvashi Rautela will be seen alongside Vineet Kumar Singh and Akshay Oberoi.
Urvashi shares: "I am excited to announce the title of my next film 'Dil Hai Gray' on the auspicious day of Vijaya Dashami. The film is very close to my heart and it was lovely working with director Susi Ganeshan sir, producer M Ramesh Reddy sir, and my co-stars Vineet Kumar Singh and Akshay Oberoi. "
"The film has created a massive response in the south industry and I am very positive about the story that it will be also be loved by the audience here. I hope my fans would bless us with their love and support. Super excited to watch my film on the big screen after a long time," she concludes. (IANS/ MBI)
Keywords: urvashi rautela, movies, bollywood, south, remake, film