Saturday November 17, 2018

Middle age chronic inflammation can increase frailty later

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middle age inflammation can lead to old age weakness
Johns Hopkins University, Pixabay
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Chronic inflammation in middle age may be linked to an increased risk of frailty and overall poorer health decades later, a new study suggests.

Overall for the study sample, each standard deviation of higher inflammation recorded in mid-life yielded a 39 per cent higher odds of frailty approximately 24 years later, the researchers said.

The prevalence of frailty in later life among people who had low levels of inflammation throughout mid-life was four to five per cent.

Chronic inflammation in mid-life
Representational Image- Old age pain, wikimedia commons

However, the prevalence of later life frailty among adults with high levels of inflammation during mid-life was nine per cent — approximately double.

“Middle adulthood may be an especially important period for poor health in older adults for multiple reasons. First, it is in middle age when the incidence of common chronic diseases, such as diabetes, begins to accelerate,” said lead author Keenan Walker, from the Johns Hopkins University School of Medicine.

“Second, compared to individuals who develop systemic disease and inflammation in later life, individuals who develop these conditions in mid-life may have a longer exposure and therefore are more susceptible to deleterious physiological effects,” Walker added.

For the study, published in The Journal of Gerontology, the research team analysed data from 5,760 adults in their 70s.

The participant’s health has been followed over the course of five medical examinations, starting in 1987-1989, when they were in their 40s and 50s.

The fifth and most recent medical visit and evaluation occurred in 2011-2013.

The investigators specifically examined measures of five markers of inflammation in the bloodstream collected during participant’s initial study visits.

Also Read: Iceland’s Reykjavik Tops Index for Green City Getaways.

Inflammatory biomarker levels were combined to create an inflammation composite score, which was used as a marker of each participant’s overall level of inflammation.

Next, all participants who completed the fifth visit were categorised as frail, pre-frail or robust depending upon how many of the following attributes they had at the time — exhaustion, slowness, low physical activity, weakness and weight loss.

Those deemed frail met three or more of these criteria, while those categorised as pre-frail met one or two of the criteria, and those categorised as robust met none of the criteria. (IANS)

 

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Grief Is Bad For The Heart: Study

Bereaved individuals are more susceptible to the negative health effects of poor sleep, the study said.

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inflammation, grief
Why grief is bad for the heart Pixabay

Sleep disturbance among people grieving the recent loss of a spouse may put them at increased risk for cardiovascular illness and death, a study has warned.

Recently widowed people are more likely to suffer from sleep disturbances, such as insomnia, that may lead to increased levels of inflammation in the body.

Higher levels of inflammation may in turn increase risk for heart diseases, showed the findings published in the journal Psychosomatic Medicine.

The study found that the link between sleep disturbances and inflammation was two to three times higher for the bereaved spouses.

sleeping, impairment, inflammation
The researchers found that the link between sleep disturbances and inflammation was two to three times higher for the bereaved spouses.
Pixabay

“The death of a spouse is an acutely stressful event and they have to adapt to living without the support of the spouse,” said Diana Chirinos from Northwestern University Feinberg School of Medicine in Chicago, US.

“Add sleep disturbance to their already stressful situation and you double the stressor. As a result, their immune system is more overactivated,” Chirinos said.

The study included 101 people with an average age of 67. Half were bereaved (identified through obituaries), and the rest were included in a control group.

The researchers compared the self-reported sleep habits of recently widowed people to the control group. Both the groups had sleep disturbances.

heart-rate, inflammation
Higher levels of inflammation may in turn increase risk for heart diseases (IANS)

The researchers found that the link between sleep disturbances and inflammation was two to three times higher for the bereaved spouses.

Also Read: Exposure to Arsenic, Lead May Spike up Risk of Heart Disease

Inflammation was measured by the level of proinflammatory cytokines, which are designed to be short-term fighters of disease but are linked to long-term risk for health problems including cardiovascular disease.

Bereaved individuals are more susceptible to the negative health effects of poor sleep, the study said. (IANS)