Monday May 21, 2018

Middle age chronic inflammation can increase frailty later

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middle age inflammation can lead to old age weakness
Johns Hopkins University, Pixabay
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Chronic inflammation in middle age may be linked to an increased risk of frailty and overall poorer health decades later, a new study suggests.

Overall for the study sample, each standard deviation of higher inflammation recorded in mid-life yielded a 39 per cent higher odds of frailty approximately 24 years later, the researchers said.

The prevalence of frailty in later life among people who had low levels of inflammation throughout mid-life was four to five per cent.

Chronic inflammation in mid-life
Representational Image- Old age pain, wikimedia commons

However, the prevalence of later life frailty among adults with high levels of inflammation during mid-life was nine per cent — approximately double.

“Middle adulthood may be an especially important period for poor health in older adults for multiple reasons. First, it is in middle age when the incidence of common chronic diseases, such as diabetes, begins to accelerate,” said lead author Keenan Walker, from the Johns Hopkins University School of Medicine.

“Second, compared to individuals who develop systemic disease and inflammation in later life, individuals who develop these conditions in mid-life may have a longer exposure and therefore are more susceptible to deleterious physiological effects,” Walker added.

For the study, published in The Journal of Gerontology, the research team analysed data from 5,760 adults in their 70s.

The participant’s health has been followed over the course of five medical examinations, starting in 1987-1989, when they were in their 40s and 50s.

The fifth and most recent medical visit and evaluation occurred in 2011-2013.

The investigators specifically examined measures of five markers of inflammation in the bloodstream collected during participant’s initial study visits.

Also Read: Iceland’s Reykjavik Tops Index for Green City Getaways.

Inflammatory biomarker levels were combined to create an inflammation composite score, which was used as a marker of each participant’s overall level of inflammation.

Next, all participants who completed the fifth visit were categorised as frail, pre-frail or robust depending upon how many of the following attributes they had at the time — exhaustion, slowness, low physical activity, weakness and weight loss.

Those deemed frail met three or more of these criteria, while those categorised as pre-frail met one or two of the criteria, and those categorised as robust met none of the criteria. (IANS)

 

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North Korea may have stopped its n-reactor, satellite images show

The report came ahead of the much-anticipated summits between North Korean leader Kim Jong-un with South Korean President Moon Jae-in and US President Donald Trump

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Kim Jong Un'
Nuclear reactors were launched under the order of Kim. VOA

North Korea may have stopped operating in its only nuclear reactor, a website specialising in North Korean affairs said on Thursday, ahead of an upcoming summits with South Korea and the US in which possible denuclearisation of the Pyongyang regime is expected to be discussed.

According to an analysis of satellite images taken on March 30 by the website 38 North, the generators of the five-megawatt experimental reactor of the Yongbyon nuclear research centre did not seem to show any activity, Efe news reported. This could point to a deactivation of the nuclear facility, which the regime said was exclusively meant to produce electricity, despite suspicions in the international community that it produced plutonium which was later reprocessed for use in nuclear weapons.

Kim Jong Un
North Korean reactors may not be working now.

The website, linked to the John Hopkins University in the US, also said there was no evidence of plutonium reprocessing taking place at the radiochemical laboratory in Yongbyon. The report, however, said the images showed an excavation project nearby, which could indicate an attempt to provide a steady water flow into the facility to ensure the reactor runs more continuously and safely in the future. It also said there was a new truck activity at the reactor, which may indicate maintenance or repairs, transport of spent fuel rods or the offloading of fresh fuel. The analysis said this area should be closely monitored in future.

Also Read: North Korea to Launch more Satellites Despite International Opposition

The report came ahead of the much-anticipated summits between North Korean leader Kim Jong-un with South Korean President Moon Jae-in and US President Donald Trump. The Moon-Kim talks on April 27 would be the first inter-Korean summit since 2007, while the May meeting with Trump would be the first between leaders of the two countries in history. IANS

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